Self-Assembled Dextrin Nanogel as Curcumin Delivery System

Catarina Gonçalves, Paula Pereira, Peter Schellenberg, Paulo J. Coutinho, Francisco M. Gama

Centre of Physics, University of Minho, Campus Gualtar, Braga, Portugal.
Centre of Physics, University of Minho, Campus Gualtar, Braga, Portugal..
IBB-Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, University of Minho, Campus de Gualtar, Braga, Portugal.

DOI: 10.4236/jbnb.2012.32024                

Abstract

Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers. In this study, we show that self-assembled nanogels obtained from hydrophobically modified dextrin are effective curcumin nanocarriers. The stability and loading efficiency of curcumin-loaded nanogel depends on the nanogel/curcumin ratio. Higher stability of the formulation is achieved in water than in PBS buffer, as evaluated by dynamic light scattering and fluorescence measurements. The in vitro release profile, using sink conditions, indicates that dextrin nanogel may perform as a suitable carrier for the controlled release of curcumin. Biological activity of curcumin-loaded nanogel in HeLa cell cultures was assessed using the MTS assay.

Keywords

Curcumin; Dextrin; Nanogel; Drug Delivery; Cytotoxicity

Conflicts of Interest

The authors declare no conflicts of interest.

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