Eosinophilic gastroenteritis in basset hound dog

Carlos E. Fonseca-Alves, Aline G. Corrêa, Fabiana Elias

Department of Clinical Veterinary Medicine, School of Veterinary Medicine and Animal Science, S?o Paulo State University, Botucatu, Brazil.
Department of Veterinary Medicine, Pioneer Union of Social Integration, Brasilia, Brazil.

DOI: 10.4236/ojas.2012.22015                

Abstract

An 1-year-old male Basset Hound dog was evaluated for chronic intermittent vomiting, hematemesis, and melena which had been ongoing for several months. The histopathologic examination revealed that all layers of the small intestine were thicker than normal. The lamina propria of the mucosa, including the villi, exhibited a prominent cellular infiltrate which consisted of numerous eosinophils and an increased numbers of plasma cells in addition to the normal lymphocytic component. The muscularis mucosa was invaded, and in some places disrupted, by eosinophils, which also infiltrated into the submucosa and muscularis propria. This report describes the pathological findings of a case of eosinophilic gastroenteritis (EG) in a dog.

Keywords

Eosinophilic Granuloma; Gastroenteritis; Canine

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Tams, T. R. (2003) Chronic diseases of the small intestine. In: Tams, T.R. Ed., Handbook of Small Animal Gastroenterology, Elsevier, Philadelphia, 211-250. doi:10.1016/B978-0-7216-8676-9.50011-9
[2]	Craven, M., Simpson, J.W., Ridyard, A.E. and Chandler, M.L. (2004) Ca-nine inflammatory bowel disease: Retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). Journal of Small Animal Practice, 45, 336- 342. doi:10.1111/j.1748-5827.2004.tb00245.x
[3]	Hendrickson, B.A., Gokhale, R. and Cho, J.H. (2002) Clinical aspects and pathophysiology of inflammatory bowel disease. Clinical Microbiology Reviews, 15, 79-94. doi:10.1128/CMR.15.1.79-94.2002
[4]	Ardizzone, S., Petrillo, M., Imbesi, V., Cerutti, R., Bollani, S. and Porro, B.G. (1999) Is maintenance therapy always necessary for patients with ulcera-tive colitis in remission? Alimentary Pharmacology & Therapeutics, 13, 373-379. doi:10.1046/j.1365-2036.1999.00473.x
[5]	Guilford, W.G. (1996) Idiopathic inflammatory bowel disease. In: Guilford, W.G., Center, S.A., Strombeck, D.R., Williams, D.A. and Meyer, D.J. Eds., Strombeck’s Small Animal Gastroenterology, WB Saunders, Philadelphia, 451-456.
[6]	Lilliehook, I. and Tvedten, H. (2003) Investigation of hypereosinophilia and po-tential treatments. Veterinary Clinics of North America: Small Animal Practice, 33, 1359-1378. doi:10.1016/S0195-5616(03)00097-4
[7]	Kleinschmidt, S., Meneses, F., Nolte, I. and Hewicker-Trautwein, M. (2006) Retrospective study on the diagnostic value of full-thickness biopsies from the stomach and intestines of dogs with chronic gastrointestinal disease symptoms. Veterinary Pathology, 43, 1000-1003. doi:10.1354/vp.43-6-1000
[8]	Brignola, C., De Simone, G., Iannone, P., Belloli, C., Evangelisti, A., Campieri, M., Belluzzi, A., Gionchetti, P., Tampieri, M. and Bertinelli, E. (1992) Influence of steroid treatment’s duration in patients with active Crohn’s disease. Inflammation Research, 36, 90-92. doi:10.1007/BF01991034
[9]	Stein, R.B. and Lichtenstein, G.R. (2001) Medical therapy for Crohn’s disease: The state of the art. Surgical Clinics of North America, 81, 71-101. doi:10.1016/S0039-6109(05)70274-7
[10]	Penninck, D.G. (2005) Trato gastrintestinal. In: Nyland, T.G. and Mattoon, J.S. Eds., Ultra-som Diagnóstico em Pequenos Animais. Editora Roca Ltda, Sao Paulo, 211- 234
[11]	Elton, E. and Hanauer, S.B. (1996) Review article: The medical management of Crohn’s disease. Alimentary Pharmacology & Therapeutics, 10, 1-22. doi:10.1111/j.1365-2036.1996.tb00173.x
[12]	Thompson, A.B.R. (1991) New developments in the use of 5-aminosalicylic acid in patients with inflammatory bowel disease. Alimentary Pharmacology & Therapeutics, 5, 449. doi:10.1111/j.1365-2036.1991.tb00515.x
[13]	Jergens, A.E. (1999) Inflammatory bowel disease: Current perspectives. Veterinary Clinics of North America: Small Animal Practice, 29, 501-521.
[14]	Johnson, S.E. (1992) Canine eosinophilic gastroenterocolitis. Seminars in Veterinary Medicine & Surgery, 7, 145- 152.
[15]	Talstad, I., Rootwelt, K. and Gjone, E. (1973) Thrombocytosis in ulcerative colitis and Crohn’s disease. Scandinavian Journall of Gastroenterology, 8, 135.