Comparative study between the effect of Momordica charantia (wild and hybrid variety) on hypoglycemic and hypolipidemic activity of alloxan induced type 2 diabetic long-evans rats

Subbroto Kumar Saha, Md. Ezazul Haque, Dipa Islam, Md. Matiar Rahman, Md. Rezuanul Islam, Anzana Parvin, Shahedur Rahman

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Department of Biotechnology & Genetic Engineering, Islamic University, Kushtia, Bangladesh.

DOI: 10.4236/jdm.2012.21022                

Abstract

This study was undertaken to evaluate the hypoglycemic and hypolipidemic effect of Momordica charantia (wild and hybrid variety) powder on alloxan induced type 2 diabetic male Long-Evans rats. Oral feeding of the M. charantia powder slightly decreased serum total cholesterol, triglyceride levels and LDL-cholesterol compared with wild, hybrid and standard drug. M. charantia wild variety showed more significant (p < 0.05, 0.01, 0.001) effect on blood glucose level when compared with hybrid variety and standard drug (glibenclamide, 5 mg/kg). At the same time rats’ serum insulin level markedly increased, wild variety showed more significant (p < 0.05, 0.01, 0.001) than glibenclamide control group and hybrid group. But M. charantia did not show any significant effect on HDL-cholesterol and liver glycogen. Thus, results of the study prove that the wild variety of M. charantia fruit have potent antidiabetic and antilipidemic property.

Keywords

Type 2 Diabetes Mellitus; Momordica Charantia; Alloxan, Hypoglycemic Effect; Hypolipidemic Effect; Glibenclamide

Conflicts of Interest

The authors declare no conflicts of interest.

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