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Mycobacterium avium subspecies paratuberculosis—An environmental trigger of type 1 diabetes mellitus

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DOI: 10.4236/jdm.2012.21014    4,340 Downloads   7,666 Views   Citations
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ABSTRACT

Type 1 diabetes mellitus (T1DM) is an autoimmune disease. The etiology of T1DM is incompletely understood but environmental agent(s) are thought to trigger T1DM in the genetically at-risk. Humans are widely exposed to Mycobacterium avium subspecies paratuberculosis (MAP), a proven multi-host chronic enteric pathogen that is mostly studied in ruminant animals and causes the inflammatory disease paratuberculosis or Johne’s disease. In humans, MAP is the putative cause of Crohn’s disease and has been linked to sarcoidosis, autoimmune thyroiditis, multiple sclerosis and autoimmune diabetes. The role of MAP as a trigger for T1DM was first postulated in 2005; subsequent studies suggest a link. This article discusses MAP, human exposure to MAP, genetic susceptibility to MAP and MAP in human disease including T1DM.

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Dow, C. (2012) Mycobacterium avium subspecies paratuberculosis—An environmental trigger of type 1 diabetes mellitus. Journal of Diabetes Mellitus, 2, 88-95. doi: 10.4236/jdm.2012.21014.

References

[1] Maahs, D.M., West, N.A., Lawrence, J.M. and Mayer-Davis, E.J. (2010) Epidemiology of type 1 diabetes. Endocrinology and Metabolism Clinics of North America, 39, 481-497.
[2] Knip, M., Veijola, R., Virtanen, S.M., Hy?ty, H., Vaarala, O. and Akerblom, H.K. (2005) Environmental triggers and determinants of type 1 diabetes. Diabetes, 54, S125-S136. doi:10.2337/diabetes.54.suppl_2.S125
[3] Dow, CT. (2005) Paratuberculosis and Type I Diabetes Mapping the TRIGR. Proceedings of the 8th International Colloquium on Paratuberculosis, August 2005, Copenhagen, Denmark, Available from: http://www.paratuberculosis.org/pubs/proc8/abst3b_o20.htm
[4] Dow, CT. (2006) Paratuberculosis and Type I diabetes: is this the trigger? Medical Hypotheses, 67, 782-785. doi:10.1016/j.mehy.2006.04.029
[5] Collins, M.T. (2003) Paratuberculosis: review of present knowledge. Acta Veterinaria Scandinavica, 44, 217-221.
[6] Hermon-Taylor, J., Bull, T.J., Sheridan, J.M., Cheng, J., Stellakis, M.L., et al. (2000) Causation of Crohn’s disease by Mycobacterium avium subspecies paratuberculosis. Canadian Journal of Gastroenterology, 14, 521-539.
[7] Stabel, J.R. (1998) Johne’s disease: A hidden threat. Journal of Dairy Science, 81, 283-288. doi:10.3168/jds.S0022-0302(98)75577-8
[8] Millar, D., Ford, J., Sanderson, J., Withey, S., Tizard, M., et al. (1996) IS900 PCR to detect Mycobacterium paratuberculosis in retail supplies of whole pasteurized cows’ milk in England and Wales. Applied and Environmental Microbiology, 62, 3446-3452.
[9] Ellingson, J.L., Anderson, J.L., Koziczkowski, J.J., Radcliff, R.P., Sloan, S.J., Allen, S.E. and Sullivan, N.M. (2005) Detection of viable Mycobacterium avium subsp. paratuberculosis in retail pasteurized whole milk by two culture methods and PCR. Journal of Food Protection, 68, 966-972.
[10] Hruska, K., Bartos, M., Kralik, P. and Pavlik, I. (2005) Mycobacterium avium subsp. paratuberculosis in powdered infant milk: Paratuberculosis in cattle—the public health problem to be solved. Veterinarni Medicina—Czech, 50, 327-335.
[11] Pickup, R.W., Rhodes, G., Arnott, S., Sidi-Boumedine, K., Bull, T.J., et al. (2005) Mycobacterium avium subsp. paratuberculosis in the catchment area and water of the River Taff in South Wales, United Kingdom, and its potential relationship to clustering of Crohn’s disease cases in the city of Cardiff. Applied and Environmental Microbiology, 71, 2130-2139. doi:10.1128/AEM.71.4.2130-2139.2005
[12] Whan, L., Ball, H.J., Grant, I.R. and Rowe, M.T. (2005) Occurrence of Mycobacterium avium subsp. paratuberculosis in untreated water in Northern Ireland. Applied and Environmental Microbiology, 71, 7107-7112. doi:10.1128/AEM.71.11.7107-7112.2005
[13] Grewal, S.K., Rajeev, S., Sreevatsan, S. and Michel, F.C. Jr. (2006) Persistence of Mycobacterium avium subsp. paratuberculosis and other zoonotic pathogens during simulated composting, manure packing, and liquid storage of dairy manure. Applied and Environmental Microbiology, 72, 565-574. doi:10.1128/AEM.72.1.565-574.2006
[14] Gill, C.O., Saucier, L. and Meadus, W.J. (2011) Mycobacterium avium subsp. paratuberculosis in dairy products, meat, and drinking water. Journal of Food Protection, 74, 480-499. doi:10.4315/0362-028X.JFP-10-301
[15] Beumer, A., King, D., Donohue, M., Mistry, J., Covert, T. and Pfaller, S. (2010) Detection of Mycobacterium avium subsp. paratuberculosis in drinking water and biofilms by quantitative PCR. Applied and Environmental Microbiology, 76, 7367-7370.
[16] Chamberlin, W., Borody, T. and Naser, S. (2007) MAP-associated Crohn’s disease MAP, Koch’s postulates, causality and Crohn’s disease. Digestive and Liver Disease, 39, 792-794. doi:10.1016/j.dld.2007.05.012
[17] Feller, M., Huwiler, K., Stephan, R., Altpeter, E., Shang, A., Furrer, H., Pfyffer, G.E., Jemmi, T., Baumgartner, A. and Egger, M. (2007) Mycobacterium avium subspecies paratuberculosis and Crohn’s disease: A systematic review and meta-analysis. Lancet Infectious Diseases, 7, 607-613. doi:10.1016/S1473-3099(07)70211-6
[18] Mendoza, J.L., San-Pedro, A., Culebras, E., Cíes, R., Taxonera, C., Lana, R., Urcelay, E., de la Torre, F., Picazo, J.J. and Diaz-Rubio, M. (2010) High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn’s disease. World Journal of Gastroenterology, 16, 4558-4563. doi:10.3748/wjg.v16.i36.4558
[19] Chiodini, R.J. (1989) Crohn’s disease and the mycobacterioses: A review and comparison of two disease entities. Clinical Microbiology Reviews, 2, 90-117.
[20] McFadden, J.J., Butcher, P.D., Chiodini, R. and Hermon-Taylor, J. (1987) Crohn’s disease-isolated mycobacteria are identical to M. para, as determined by DNA probes that distinguish between mycobacterial species. Journal of Clinical Microbiology, 25, 796-801.
[21] Sechi, L.A., Mura, M., Tanda, F., et al. (2001) Identification of Mycobacterium avium subsp. paratuberculosis in biopsy specimens from patients with Crohn’s disease identified by in situ hybridization. Journal of Clinical Microbiology, 39, 4514-4527. doi:10.1128/JCM.39.12.4514-4517.2001
[22] Naser, S.A., Ghobrial, G., Romero, C. and Valentine, J.F. (2004) Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn’s disease. Lancet, 364, 1039-1044. doi:10.1016/S0140-6736(04)17058-X
[23] Naser, S.A., Collins, M.T., Crawford, J.T. and Valentine, J.F. (2009) Culture of Mycobacterium avium subspecies paratuberculosis (MAP) from the Blood of Patients with Crohn’s disease: A Follow-Up Blind Multi Center Investigation. The Open Inflammation Journal, 2, 22-23. doi:10.2174/1875041900902010022
[24] Sechi, L.A., Scanu, A.M., Molicotti, P., et al. (2005) Detection and Isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn’s disease in Sardinia. American Journal of Gastroenterology, 100, 1529-1536. doi:10.1111/j.1572-0241.2005.41415.x
[25] Scanu, A.M., Bull, T.J., Cannas, S., Sanderson, J.D., Sechi, L.A., Dettori, G., Zanetti, S. and Hermon-Taylor, J. (2007) Mycobacterium avium subspecies paratuberculosis infection in cases of irritable bowel syndrome and comparison with Crohn’s disease and Johne’s disease: Common neural and immune pathogenicities. Journal of Clinical Microbiology, 45, 3883-3890. doi:10.1128/JCM.01371-07
[26] Pierce, E.S. (2010) Ulcerative colitis and Crohn’s disease: Is Mycobacterium avium subspecies paratuberculosis the common villain? Gut Pathog, 2, 21. doi:10.1186/1757-4749-2-21
[27] Olbe, L. (2008) Concept of Crohn’s disease being conditioned by four main components, and irritable bowel syndrome being an incomplete Crohn’s disease. Scandinavian Journal of Gastroenterology, 43, 234-241. doi:10.1080/00365520701676971
[28] el-Zaatari, F.A.K., Naser, S.A., Markesich, D.C., Kalter, D.C., Engstand, L. and Graham, D.Y. (1996) Identification of Mycobacterium avium complex in sarcoidosis. Journal of Clinical Microbiology, 34, 2240-2245.
[29] Nerup, J., Platz, P., Andersen, O.O., Christy, M., Lyngsoe, J. (1974) HL-A antigens and diabetes mellitus. Lancet, 2, 864-866. doi:10.1016/S0140-6736(74)91201-X
[30] Singal, D.P. and Blajchman, M.A. (1973) Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes, 22, 429-432.
[31] Canonne-Hergaux, F., Gruenheid, S., Govoni, G. and Gros, P. (1999) The Nramp1 protein and its role in resistance to infection and macrophage function. Proceedings of the Association of American Physicians, 111, 283-289. doi:10.1046/j.1525-1381.1999.99236.x
[32] Lapham, A.S., Phillips, E.S. and Barton, C.H. (2004) Transcriptional control of Nramp1: a paradigm for the repressive action of c-Myc. Biochemical Society Transactions, 32, 1084-1086.
[33] Wyllie, S., Seu, P. and Goss, J.A. (2002) The natural resistance-associatedmacrophage protein 1 Slc11a1 (formerly Nramp1) and iron metabolism in macrophages. Microbes and Infection, 4, 351-359. doi:10.1016/S1286-4579(02)01548-4
[34] Hackam, D.J., Rotstein, O.D., Zhang, W., Gruenheid, S., Gros, P. and Grinstein, S. (1998) Host resistance to intracellular infection: Mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. Journal of Experimental Medicine, 188, 351-364. doi:10.1084/jem.188.2.351
[35] Dubaniewicz, A., Jamieson, S.E., Dubaniewicz-Wybieralska, M., Fakiola, M., Nancy Miller, E. and Blackwell, J.M. (2005) Association between SLC11A1 (formerly NRAMP1) and the risk of sarcoidosis in Poland. European Journal of Human Genetics, 13, 829-834. doi:10.1038/sj.ejhg.5201370
[36] Stienstra, Y., van der Werf, T.S., Oosterom, E., Nolte, I.M., van der Graaf, W.T., Etuaful, S., Raghunathan, P.L., Whitney, E.A., Ampadu, E.O., Asamoa, K., Klutse, E.Y., te Meerman, G.J., Tappero, J.W., Ashford, D.A. and van der Steege, G. (2006)Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism. Genes & Immunity, 7, 185-189. doi:10.1038/sj.gene.6364281
[37] Ruiz-Larranaga, O., Garrido, J.M., Manzano, C., Iriondo, M., Molina, E., Gil, A., Koets, A.P., Rutten, V.P., Juste, R.A. and Estonba, A. (2010) Identification of single nucleotide polymorphisms in the bovine solute carrier family 11 member 1 (SLC11A1) gene and their association with infection by Mycobacterium avium subspecies paratuberculosis. Journal of Dairy Science, 93, 1713-1721. doi:10.3168/jds.2009-2438
[38] Korou, L.M., Liandris, E., Gazouli, M. and Ikonomopoulos, J. (2010) Investigation of the association of the SLC11A1 gene with resistance/sensitivity of goats (Capra hircus) to paratuberculosis. Veterinary Microbiology, 144, 353-358. doi:10.1016/j.vetmic.2010.01.009
[39] Purdie, A.C., Plain, K.M., Begg, D.J., de Silva, K. and Whittington, R.J. (2011) Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: A review. Comparative Immunology, Microbiology and Infectious Diseases, 34, 197-208.
[40] Roupie, V., Rosseels, V., Piersoel, V., Zinniel, D.K., Barletta, R.G. and Huygen, K. (2008) Genetic resistance of mice to Mycobacterium paratuberculosis is influenced by Slc11a1 at the early but not at the late stage of infection. Infection and Immunity, 76, 2099-2105. doi:10.1128/IAI.01137-07
[41] Blackwell, J.M., Searle, S., Mohamed, H. and White, J.K. (2003) Divalentcation transport and susceptibility to infectious and autoimmune disease: Continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story. Immunology Letters, 85, 197-203. doi:10.1016/S0165-2478(02)00231-6
[42] Hatta, M., Ratnawati, Tanaka, M., Ito, J., Shirakawa, T. and Kawabata, M. (2010) NRAMP1/SLC11A1 gene polymorphisms and host susceptibility to Mycobacterium tuberculosis and M. leprae in South Sulawesi, Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health, 41, 386-394.
[43] Bellamy, R., Ruwende, C., Corrah, T., McAdam, K.P., Whittle, H.C. and Hill, A.V. (1998) Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. New England Journal of Medicine, 338, 640-644. doi:10.1056/NEJM199803053381002
[44] Ates, O., Dalyan, L., Musellim, B., Hatemi, G., Turker, H., Ongen, G., Hamuryudan, V. and Topal-Sarikaya, A. (2009) NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis. Journal of Immunogenetics, 36, 15-19. doi:10.1111/j.1744-313X.2008.00814.x
[45] Mohamed, H.S., Ibrahim, M.E., Miller, E.N., White, J.K., Cordell, H.J., Howson, J.M., Peacock, C.S., Khalil, E.A., El Hassan, A.M. and Blackwell, J.M. (2004) SLC11A1 (formerly NRAMP1) and susceptibility to visceral leishmaniasis in The Sudan. European Journal of Human Genetics, 12, 66-74. doi:10.1038/sj.ejhg.5201089
[46] Kotze, M.J., de Villiers, J.N., Rooney, R.N., Grobbelaar, J.J., Mansvelt, E.P., Bouwens, C.S., Carr, J., Stander, I. and du Plessis, L. (2001) Analysis of the NRAMP1 gene implicated in iron transport: Association with multiple sclerosis and age effects. Blood Cells, Molecules & Diseases, 27, 44-53. doi:10.1006/bcmd.2000.0349
[47] Gazouli, M., Sechi, L., Paccagnini, D., Sotgiu, S., Arru, G., et al. (2008) NRAMP1 polymorphism and viral factors in Sardinian multiple sclerosis patients. Canadian Journal of Neurological Sciences, 35, 491-494.
[48] Gazouli, M., Atsaves, V., Mantzaris, G., Economou, M., Nasioulas, G., Evangelou, K., Archimandritis, A.J. and Anagnou, N.P. (2008) Role of functional polymorphisms of NRAMP1 gene for the development of Crohn’s disease. Inflammatory Bowel Diseases, 14, 1323-1330. doi:10.1002/ibd.20488
[49] Kotlowski, R., Bernstein, C.N., Silverberg, M.S. and Krause, D.O. (2008) Population-based case-control study of alpha 1-antitrypsin and SLC11A1 in Crohn’s disease and ulcerative colitis. Inflammatory Bowel Diseases, 14, 1112-1117. doi:10.1002/ibd.20425
[50] Sechi, L.A., Gazouli, M., Sieswerda, L.E., Molicotti, P., Ahmed, N., Ikonomopoulos, J., Scanu, A.M., Paccagnini, D. and Zanetti, S. (2006) Relationship between Crohn’s disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients. World Journal of Gastroenterology, 12, 7161-7164.
[51] Paccagnini, D., Sieswerda, L., Rosu, V., Masala, S., Pacifico, A., Gazouli, M., Ikonomopoulos, J., Ahmed, N., Zanetti, S. and Sechi, L.A. (2009) Linking chronic infection and autoimmune diseases: Mycobacterium avium subspecies paratuberculosis, SLC11A1 polymorphisms and type-1 diabetes mellitus. PLoS One, 214, e7109. doi:10.1371/journal.pone.0007109
[52] Takahashi, K., Satoh, J., Kojima, Y., Negoro, K., Hirai, M., Hinokio, Y., Kinouchi, Y., Suzuki, S., Matsuura, N., Shimosegawa, T. and Oka, Y. (2004) Promoter polymorphism of SLC11A1 (formerly NRAMP1) confers susceptibility to autoimmune type 1 diabetes mellitus in Japanese. Tissue Antigens, 63, 231-236. doi:10.1111/j.1399-0039.2004.000172.x
[53] Eisenbarth, G.S. (1986) Type I diabetes mellitus. A chronic autoimmune disease. New England Journal of Medicine, 314, 1360-1368.
[54] Rosu, V., Ahmed, N., Paccagnini, D., Gerlach, G., Fadda, G., Hasnain, S.E., Zanetti, S. and Sechi, L.A. (2009) Specific immunoassays confirm association of Mycobacterium avium Subsp. paratuberculosis with type-1 but not type-2 diabetes mellitus. PLoS One, 4, e4386. doi:10.1371/journal.pone.0004386
[55] Sechi, L.A., Ruehl, A., Ahmed, N., Usai, D., Paccagnini, D., Felis, G.E. and Zanetti, S. (2007) Mycobacterium avium subspecies paratuberculosis infects and multiplies in enteric glial cells. World Journal of Gastroenterology, 13, 5731-5735.
[56] Sechi, L.A., Rosu, V., Pacifico, A., Fadda, G., Ahmed, N. and Zanetti, S. (2008) Humoral immune responses of type 1 diabetes patients to Mycobacterium avium subsp. paratuberculosis lend support to the infectious trigger hypothesis. Clinical and Vaccine Immunology, 15, 320-326. doi:10.1128/CVI.00381-07
[57] Oldstone, M.B. (1987) Molecular mimicry and autoimmune disease. Cell, 50, 819-820. doi:10.1016/0092-8674(87)90507-1
[58] Guilherme, L., Fae, K., Oshiro, S.E. and Kalil, J. (2005) Molecular pathogenesis of rheumatic fever and rheumatic heart disease. Expert Reviews in Molecular Medicine, 7, 1-15. doi:10.1017/S146239940501015X
[59] Raska, M. and Weigl, E. (2005) Heat shock proteins in autoimmune diseases. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc Czech Republic, 149, 243-249.
[60] Parsell, D.A. and Lindquist, S. (1993) The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins. Annual Review of Genetics, 27, 437-496. doi:10.1146/annurev.ge.27.120193.002253
[61] Jarjour, W.N., Jeffries, B.D., Davis IV, J.S., et al. (1991) Autoantibodies to human stress proteins. A survey of various rheumatic and other inflammatory diseases. Arthritis Rheum, 34, 1133-1138. doi:10.1002/art.1780340909
[62] Moudgil, K.D., Chang, T.T., Eradat, H., et al. (1997) Diversification of T cell responses to carboxy-terminal determinants within the 65 kD heat-shock protein is involved in regulation of autoimmune arthritis. Journal of Experimental Medicine, 185, 1307-1316. doi:10.1084/jem.185.7.1307
[63] Miyata, M., Kogure, A., Sato, H., et al. (1995) Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase. Clinical Rheumatology, 14, 673-677. doi:10.1007/BF02207935
[64] Vilagut, L., Pares, A., Vinas, O., et al. (1992) Antibodies to mycobacterial 65 kD heat shock protein cross-react with the main mitochondrial antigens in patients with primary biliary cirrhosis. European Journal of Clinical Investigation, 27, 667-672. doi:10.1046/j.1365-2362.1997.1690724.x
[65] Danieli, M.G., Candela, M., Ricciatti, A.M., et al. (1992) Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma). Journal of Autoimmunity, 5, 443-445. doi:10.1016/0896-8411(92)90004-A
[66] Yokota, S., Tsubaki, S., Kuriyama, T., et al. (1993) Presence in Kawasaki disease of antibodies to mycobacterial heatshock protein HSP65 and autoantibodies to epitopes of human HSP65 cognate antigen. Clinical Immunology and Immunopathology, 67, 163-170.
[67] Direskeneli, H. and Saruhan-Direskeneli, G. (2003) The role of heat shock proteins in Behcet’s disease. Clinical and Experimental Rheumatology, 21, S44-48. doi:10.1006/clin.1993.1060
[68] Aggarwal, A., Chag, M., Sinha, N. and Naik, S. (1996) Takayasu’s arteritis: Role of Mycobacterium tuberculosis and its 65 kDa heat shock protein. International Journal of Cardiology, 55, 49-55. doi:10.1016/0167-5273(96)02660-5
[69] Jones, D.B., Hunter, N.R. and Duff, G.W. (1990) Heat- shock protein 65 as a beta cell antigen of insulin-dependent diabetes. Lancet, 336, 583-585. doi:10.1016/0140-6736(90)93390-B
[70] Jones, D.B., Coulson, A.F. and Duff, G.W. (1993) Sequence homologies between hsp60 and autoantigens. Immunology Today, 14, 115-118. doi:10.1016/0167-5699(93)90210-C
[71] Akerblom, H.K. and Knip, M. (1998) Putative environmental factors in Type 1 diabetes. Diabetes/Metabolism Reviews, 14, 31-67. doi:10.1002/(SICI)1099-0895(199803)14:1<31::AID-DMR201>3.0.CO;2-A
[72] Gerstein, H.C. (1994) Cow’s milk exposure and Type I diabetes mellitus. A critical overview of the clinical literature. Diabetes Care, 17, 13-19. doi:10.2337/diacare.17.1.13
[73] Gimeno, S.G. and de Souza, J.M. (1997) DM and milk consumption. A case-control study in Sao Paulo, Brazil. Diabetes Care, 20, 1256-1260. doi:10.2337/diacare.20.8.1256
[74] Akerblom, H.K. (2010) The TRIGR Study Group. The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: Recruitment, intervention and follow-up. Diabetologia, 54, 627-633.
[75] Knip, M., Virtanen, S.M., Seppa, K., Ilonen, J., Savilahti, E., Vaarala, O., Reunanen, A., Teramo, K., Hamalainen, A.M., Paronen, J., Dosch, H.M., Hakulinen, T. and Akerblom, H.K. (2010) Dietary intervention in infancy and later signs of beta-cell autoimmunity. Finnish TRIGR Study Group. New England Journal of Medicine, 363, 1900-1908. doi:10.1056/NEJMoa1004809
[76] D’Amore, M., Lisi, S., Sisto, M., Cucci, L. and Dow, C.T. (2010) Molecular identification of Mycobacterium avium subspecies paratuberculosis in an Italian patient with Hashimoto’s thyroiditis and Melkersson-Rosenthal syndrome. Journal of Medical Microbiology, 59, 137-139.
[77] Sisto, M., Cucci, L., D’Amore, M., Dow, T.C., Mitolo, V. and Lisi, S. (2010) Proposing a relationship between Mycobacterium avium subspecies paratuberculosis infection and Hashimoto’s thyroiditis. Scandinavian Journal of Infectious Diseases, 42, 787-790. doi:10.3109/00365541003762306
[78] Cossu, D., Cocco, E., Paccagnini, D., Masala, S., Ahmed, N., et al. (2011) Association of Mycobacterium avium subsp. paratuberculosis with Multiple Sclerosis in Sardinian Patients. PLoS One, 6, e18482. doi:10.1371/journal.pone.0018482
[79] Gazouli, M., Sechi, L., Paccagnini, D., Sotgiu, S., Arru, G., et al. (2008) NRAMP1 polymorphism and viral factors in Sardinian multiple sclerosis patients. Canadian Journal of Neurological Sciences, 35, 491-494.
[80] Tavornpanich, S., Johnson, W. O., Anderson, R.J. and Gardner, I.A. (2008) Herd characteristics and management practices associated with seroprevalence of Mycobacterium avium subspecies paratuberculosis infection in dairy herds. American Journal of Veterinary Research, 69, 904-911. doi:10.2460/ajvr.69.7.904
[81] http://www.tseandfoodsafety.org/paratuberculosis.html
[82] Click, R.E. and Van Kampen, C.L. (2010) Assessment of Dietzia subsp. C79793-74 for treatment of cattle with evidence of paratuberculosis. Virulence, 1, 145-155. doi:10.4161/viru.1.3.10897
[83] Click, R.E. and Van Kampen, C.L. (2009) Short communication: progression of Johne’s disease curtailed by a probiotic. Journal of Dairy Science, 92, 4846-4851. doi:10.3168/jds.2009-2129
[84] Click, R.E. (2011) Successful treatment of asymptomatic or clinically terminal bovine Mycobacterium avium subspecies paratuberculosis infection (Johne’s disease) with the bacterium Dietzia used as a probiotic alone or in combination with dexamethasone: Adaption to chronic human diarrheal diseases. Virulence, 2, 131-143.
[85] Kormendy, B. (1994) The effect of vaccination on the prevalence of paratuberculosis in large dairy herds. Veterinary Microbiology, 41, 117-125. doi:10.1016/0378-1135(94)90141-4
[86] van Schaik, G., Kalis, C.H., Benedictus, G., Dijkhuizen, A.A. and Huirne, R.B. (1996) Cost-benefit analysis of vaccination against paratuberculosis in dairy cattle. Veterinary Record, 139, 624-627.
[87] Gwozdz, J.M., Thompson, K.G., Manktelow, B.W., Murray, A. and West, D.M. (2000) Vaccination against paratuberculosis of lambs already infected experimentally with Mycobacterium avium subspecies paratuberculosis. Australian Veterinary Journal, 78, 560-566. doi:10.1111/j.1751-0813.2000.tb11902.x
[88] Mackintosh, C.G., Labes, R.E. and Griffin, J.F. (2005) The effect of Johne’s vaccination on tuberculin testing in farmed red deer (Cervus elaphus). New Zealand Veterinary Journal, 53, 216. doi:10.1080/00480169.2005.36549
[89] Sechi, L.A., Mara, L., Cappai, P., Frothingam, R., Ortu, S., Leoni, A., Ahmed, N. and Zanetti, S. (2006) Immunization with DNA vaccines encoding different mycobacterial antigens elicits a Th1 type immune response in lambs and protects against Mycobacterium avium subspecies paratuberculosis infection. Vaccine, 24, 229-235. doi:10.1016/j.vaccine.2005.08.086
[90] Borody, T.J., Bilkey, S., Wettstein, A.R., Leis, S., Pang, G. and Tye, S. (2007) Anti-mycobacterial therapy in Crohn’s disease heals mucosa with longitudinal scars. Digestive Diseases Sciences, 39, 438-444. doi:10.1016/j.dld.2007.01.008
[91] Hermon-Taylor, J. (2002) Treatment with drugs active against Mycobacterium avium subspecies paratuberculosis can heal Crohn’s disease: More evidence for a neglected public health tragedy. Digestive and Liver Disease, 34, 9-12. doi:10.1016/S1590-8658(02)80052-4
[92] Bull, T.J., Gilbert, S.C., Sridhar, S., Linedale, R., Dierkes, N., Sidi-Boumedine, K. and Hermon-Taylor, J. (2007) A novel multi-antigen virally vectored vaccine against Mycobacterium avium subspecies paratuberculosis. PLoS One, 2, e1229. doi:10.1371/journal.pone.0001229
[93] Tao, B., Pietropaolo, M., Atkinson, M., Schatz, D. and Taylor, D. (2010) Estimating the cost of type 1 diabetes in the U.S.: A propensity score matching method. PLoS One, 5, e11501. doi:10.1371/journal.pone.0011501

  
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