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Comparative Efficacy of Tagetes erecta and Centella asiatica Extracts on Wound Healing in Albino Rats

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DOI: 10.4236/cm.2011.24023    4,150 Downloads   9,087 Views   Citations

ABSTRACT

The study was undertaken to evaluate the comparative efficacy of hydroalcoholic extracts of leaves of Tagetes erecta (T. erecta) and aerial parts of Centella asiatica (C. asiatica) on Excision, Incision and Dead space wound models in albino rats. Extract of T. erecta and C. asiatica (P < 0.001) showed significant increase in rate of wound contraction, epithelization and formation of scar faster in excision wound model compare to control group. T. erecta extract (250 and 500 mg/kg) showed significantly increased the wound breaking strength in incision wound model and wet and dry granulation tissue weights, breaking strength in a dead space wound model compare to control and C. asiatica treated group (P < 0.001). In this investigation the work is conclude that the comparison made between the above two plants, the T. erecta extract showed potent wound healing activity then the reported C. asiatica in different wound parameters.

Cite this paper

S. Chatterjee, T. Prakash, D. Kotrsha, N. Rama Rao and D. Goli, "Comparative Efficacy of Tagetes erecta and Centella asiatica Extracts on Wound Healing in Albino Rats," Chinese Medicine, Vol. 2 No. 4, 2011, pp. 138-142. doi: 10.4236/cm.2011.24023.

References

[1] T. Ghosh, A. Bose, G. K. Dash and T. K. Maity, “Wound Healing Activity of Tagetes erecta Linn Leaves,” 2004. URL http://www. Pharmainfo.net/exclusive/reviews
[2] B. Brinkhaus, “Centella asiatica in Traditional and Modern Phytomedicine―a Pharmacological and Clinical Profile, Part I: Botany Chemistry Preparations,” Perfusion, Vol. 11, 1998, pp. 466-474.
[3] B. Brinkhaus, “Centella asiatica in Traditional and Modern Phytomedicine―a Pharmacological and Clinical Profile, Part II: Botany Chemistry Preparations,” Perfusion, Vol. 11, 1998, pp. 508-520.
[4] R. P. Lubadie, “An Ehnopharmacognostic Approach to the Search for Immunomodulators of Plant Origin,” Planta Medica, Vol. 55, 1989, pp. 339-348. doi:10.1055/s-2006-962024
[5] S. Chaudhary, S. Poddar, S. Sarkar and P. K. Das, “New Multidrug Regimen with Indigenous Drugs and Dapsone in the Treatment of Lepromatous Leprosy,” Indian Journal of Dermatology, Vol. 32, No. 3, 1987, pp. 63-67.
[6] S. S. Hong, J. K. Kim, H. Li and C. K. Shim, “Advanced Formulation and Pharmacological Activity of Hydrogel of the Titrated Extract of Centella asiatica,” Archives of Pharmacal Research, Vol. 28, No. 4, 2005, pp. 502-508. doi:10.1007/BF02977683
[7] A. Shukla, A. M. Rasik, G. K. Jain, R. Shankar, D. K. Kulashrestha and B. N. Dhawan, “In vitro Wound Healing Activity of Asiaticoside Isolated from Centella asiatica,” Journal of Ethnopharmacology, Vol. 65, No. 1, 1999, pp. 1-11. doi:10.1016/S0378-8741(98)00141-X
[8] S. Somashekar, S. L. Udupa and A. L. Udupa, “Effect of Centella asiatica Linn (Umbelliferae) on Normal and Dexmetasone Suppressed Wound Healing in Wistar Albino Rats,” The International Journal of Lower Extremity Wounds, Vol. 5, 2006, p. 136.
[9] Organization for Economic cooperation and development (OECD), “OECD Guidelines for Testing of Chemicals Acute Oral Toxicity,” OECD, Paris, 1993. p. 401.
[10] J. J. P. Morton and M. H. Malone, “Evaluation of Vulnary Activity by an Open Wound Procedure in Rats,” Archives Internationales de Pharmacodynamie, Vol. 196, 1997, pp. 117-126.
[11] H. P. Ehrlich and T. K. Hunt, “Effect of Cortisone and Anabolic Steroids on the Tensilestrength of Healing Wounds,” British Journal of Surgery, Vol. 170, 1969, pp. 203-206.
[12] K. H. Lee, “Studies on the Mechanism of Action of Salicylates II. Retardation of Wound Healing by Aspirin,” Journal of Pharmaceutical Sciences, Vol. 57, No. 6, 1968, pp. 1042-1043. doi:10.1002/jps.2600570633
[13] B. S. Reddy, R. K. K. Reddy, V. G. M. Naidu, K. Madhusudhana, S. B. Agwane, S. Ramakrishna and P. V. Diwan, “Evaluation of Antimicrobial, Antioxidant and Wound Healing Potentials of Holoptelea integrifolia,” Journal of Ethnopharmacology, Vol. 115, No. 2, 2008, pp. 249-256. doi:10.1016/j.jep.2007.09.031
[14] I. Süntar, U. Koca, H. Keles and E. K. Akko, “Wound Healing Activity of Rubus sanctus Schreber (Rosaceae): Preclinical Study in Animal Models,” Evidence-Based Complementary and Alternative Medicine, Vol. 2011, Article ID: 816156.
[15] P. J. Michelle, M. Cristiana, T. G. R. Ana Lu′ cia, T. F. Alik, A. F. R. Rodney, M. O. S. Ilza, A. F. Mary and E. C. Jo?ao, “Evaluation of Wound Healing Properties of Arrabidaea chica Verlot Extract,” Journal of Ethnopharmacology, Vol. 118, No. 3, 2008, pp. 361-366. doi:10.1016/j.jep.2008.04.024
[16] S. K. Prasad, R. Kumar, D. K. Patel and S. Hemalatha, “Wound Healing Activity of Withania Coagulans in Streptozotocin-Induced Diabetic Rats,” Pharmaceutical Biology, Vol. 48, No, 12, 2010, pp. 1397-1404. doi:10.3109/13880209.2010.486837
[17] M. M. Alam, S. A. Islam, Y. Mohammed, N. S. Juyena and M. A. Hashim, “Comparative Efficacy of Two Medicinal Plant Extracts and an Antibiotic on Wound Healing,” Pakistan Journal of Biological Sciences, Vol. 8, No. 5, 2005, pp. 740-743. doi:10.3923/pjbs.2005.740.743

  
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