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Oral Desmopressin in the Management of Adults with Nocturia

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DOI: 10.4236/oju.2011.14015    2,781 Downloads   5,589 Views  

ABSTRACT

We investigated the efficacy of oral desmopressin in the treatment of adult nocturia. In an analytical study between 2007-2009 in Zahedan-Iran, Thirty patients ≥55 years with verified nocturia (≥two voids/night) were enrolled. Patients with a history of an obstructive cause of nocturia, those with diseases getting worse by the anti-diuretic affect of desmopressin and those with well-defined curable causes (e.g. cystitis) were excluded. Patients received 0.2 mg of oral desmopressin at bed time for a period of 3 weeks. p < 0.05 was taken as the significant level. All 30 patients enrolled completed the trial. Fourteen (47 %) patients receiving desmopressin had fewer than half the number of nocturnal voids relative to base line (p < 0.001). The mean number of nocturnal voids decreased from 4.6 to 2.4 (p < 0.001). Fatigue (10%), headache (3%) and dizziness (3%) were reported. All adverse events were of mild intensity and there were no instances of hyponatremia. Oral desmopressin is an effective treatment in patients with nocturia and is well-tolerated.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

S. Gooran, S. Nasirmohtaram, M. Mohseni and B. Narouie, "Oral Desmopressin in the Management of Adults with Nocturia," Open Journal of Urology, Vol. 1 No. 4, 2011, pp. 72-75. doi: 10.4236/oju.2011.14015.

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