Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis

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DOI: 10.4236/ojra.2017.71004    252 Downloads   304 Views  

ABSTRACT

To determine the effect of tocilizumab (TCZ) on reactive oxygen species (ROS) in 11 patients with rheumatoid arthritis (RA), reactive oxygen metabolites (d-ROM) were measured using a Free Radical Elective Evaluator. The Disease Activity Score (DAS28) and matrix metalloproteinase-3 (MMP-3) level were also evaluated. d-ROM measured 392 ± 110 Carratelli units [U. CARR] on initiation of TCZ, and significantly decreased to 237 ± 82, 248 ± 88, and 226 ± 91 U.CARR after 3, 6, and 12 months, respectively (p < 0.05). The DAS28-4-ESR was 4.77 ± 1.0 on initiation of TCZ, and significantly decreased to 2.19 ± 1.23, 1.51 ± 0.71, and 1.48 ± 0.48 after 3, 6, and 12 months, respectively (p < 0.05). Serum MMP-3 level was 197 ± 150 ng/ml on initiation of TCZ, and was significantly decreased to 92 ± 56, 73 ± 53, and 69 ± 41 ng/ml after 3, 6, and 12 months, respectively (p < 0.05). Pearson analysis showed that d-ROM value was significantly correlated with DAS28 (r = 0.543, p < 0.05), but not with MMP-3 (r = 0.174, p = 0.29). TCZ was found to rapidly and significantly decrease ROS in patients with RA, and d-ROM value may be useful as a marker of disease activity of RA.

Cite this paper

Kondo, N. , Arai, K. , Netsu, T. , Kanai, T. , Sano, H. , Okumura, G. , Kijima, Y. , Fujisawa, J. and Endo, N. (2017) Tocilizumab Significantly Decreases Reactive Oxygen Species Level in Patients with Rheumatoid Arthritis. Open Journal of Rheumatology and Autoimmune Diseases, 7, 46-52. doi: 10.4236/ojra.2017.71004.

References

[1] Bauerova, K. and Bezek, S. (1999) Role of Reactive Oxygen and Nitrogen Species in Etiopathogenesis of Rheumatoid Arthritis. General Physiology and Biophysics, 18, 15-20.
[2] Weyand, C.M. and Goronzy, J.J. (1997) The Molecular Basis of Rheumatoid Arthritis. Journal of Molecular Medicine, 75, 772-785.
https://doi.org/10.1007/s001090050167
[3] Biemond, P., Swaak, A.J. and Koster, J.F. (1984) Protective Factors against Oxygen Free Radicals and Hydrogen Peroxide in Rheumatoid Arthritis Synovial Fluid. Arthritis & Rheumatology, 27, 760-765.
https://doi.org/10.1002/art.1780270706
[4] Kageyama, Y., Takahashi, M., Nagafusa, T., Torikai, E. and Nagano, A. (2008) Etanercept Reduces the Oxidative Stress Marker Levels in Patients with Rheumatoid Arthritis. Rheumatology International, 28, 245-251.
https://doi.org/10.1007/s00296-007-0419-1
[5] Kageyama, Y., Takahashi, M., Ichikawa, T., Torikai, E. and Nagano, A. (2008) Reduction of Oxidative Stress Marker Levels of Anti-TNF-α Antibody, Infliximab, in Patients with Rheumatoid Arthritis. Clinical and Experimental Rheumatology, 26, 73-80.
[6] Moon, D., Kim, M.O., Kang, S.H., Choi, Y.H. and Kim, G.Y. (2009) Sulforaphane Suppresses TNF-Alpha-Mediated Activation of NF-Kappa B and Induces Apoptosis through Activation of Reactive Oxygen Species-Dependent Caspase-3. Cancer Letters, 274, 132-142.
https://doi.org/10.1016/j.canlet.2008.09.013
[7] Cesarone. M.R., Belcaro, G., Carattelli, M., Cornelli, U., De Sanctis, M.T., Incandela, L., Barsotti, A., Terranova, R. and Nicolaides, A. (1999) A Simple Test to Monitor Oxidative Stress. International Angiology, 18, 127-130.
[8] Hirao, M., Yamasaki, N., Oze, H., Ebina, K., Nampei, A., Kawato, Y., Shi, K., Yoshikawa, H., Nishimoto, N. and Hashimoto, J. (2012) Serum Level of Oxidative Stress Marker Is Dramatically Low in Patients with Rheumatoid Arthritis Treated with Tocilizumab. Rheumatology International, 32, 4041-4045.
https://doi.org/10.1007/s00296-011-2135-0
[9] Nakajima, A., Aoki, Y., Shibata, Y., Sonobe, M., Terajima, F., Takahashi, H., Saito, M., Taniguchi, S., Yamada, M. and Nakagawa, K. (2014) Identification of Clinical Parameters Associated with Serum Oxidative Stress in Patients with Rheumatoid Arthritis. Modern Rheumatology, 24, 926-930.
https://doi.org/10.3109/14397595.2014.891495
[10] Arnett, F.C., Edworthy, S.M., Bloch, D.A., McShane, D.J., Fries, J.F., Cooper, N.S., Healey, L.S., Kaplan, S.R., Liang, M.H. and Luthra, H.S. (1988) The American Rheumatism Association 1987 Revised Criteria for the Classification of Rheumatoid Arthritis. Arthritis & Rheumatology, 31, 315-324.
https://doi.org/10.1002/art.1780310302
[11] Datta, S., Kundu, S., Ghosh, P., De, S., Ghosh, A. and Chatterjee, M. (2014) Correlation of Oxidant Status with Oxidative Tissue Damage in Patients with Rheumatoid Arthritis. Clinical Rheumatology, 33, 1557-1564.
https://doi.org/10.1007/s10067-014-2597-z
[12] Sato, M., Miyazaki, T., Nagaya, T., Murata, Y., Ida, N., Maeda, K. and Seo, H. (1996) Antioxidants Inhibit Tumor Necrosis Factor-α Mediated Stimulation of Interleukin-8, Monocyte Chemoattractant Protein-1, and Collagenase Expression in Cultured Human Synovial Cells. The Journal of Rheumatology, 23, 432-438.
[13] Netsu, T., Kondo, N., Arai, K., Fujisawa, J. and Endo, N. (2013) The Serum Oxidative Stress Values before and after Treatment of Biologics in Patients with Rheumatoid Arthritis. Archives of Niigata Society of Orthopaedic Surgery, 29, 37-40. (In Japanese)
[14] Yamanaka., K., Kondo, N., Arai, K., Fujisawa, J., Netsu, T. and Endo, N. (2013) Etanercept Decreases Serum Oxidative Stress in Patients with Rheumatoid Arthritis. Archives of Niigata Society of Orthopaedic Surgery, 29, 73-76. (In Japanese)

  
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