Decreasing serum uric acid levels might be associated with improving estimated glomerular filtration rate (eGFR) in Japanese men

Nobuyuki Miyatake, Kenichi Shikata, Hirofumi Makino, Takeyuki Numata

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DOI: 10.4236/health.2011.38082                

Abstract

The link between changes in a subject’s serum uric acid levels and his estimated glomerular filtration rate (eGFR) was evaluated in Japanese men. We used data for 108 Japanese men (45.3 ± 8.0 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. eGFR was weakly correlated with serum uric acid levels (r = –0.287, p = 0.0026) at baseline. Subjects were given advice for dietary and life-style improvement. At the 1-year follow up, almost metabolic syndrome components were significantly improved. However, blood sugar and uric acid did not change and eGFR was significantly decreased. The changes in eGFR were weakly correlated with abdominal circum-ference (r = –0.249, p = 0.0094) and uric acid (r = –0.340, p = 0.0003). A decrease in serum uric acid levels may be associated with improving eGFR in Japanese men.

Keywords

Abdominal Circumference; Uric Acid; Estimated Glomerular Filtration Rate (eGFR); Metabolic Syndrome; Lifestyle Modification

Conflicts of Interest

The authors declare no conflicts of interest.

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