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Prevalence and Risk Factors of Hepatitis B and Hepatitis C Virus Infections among Patients with Chronic Renal Failure in Zabeed City, Yemen Republic

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DOI: 10.4236/ojmm.2015.53017    2,784 Downloads   3,444 Views   Citations

ABSTRACT

Background and Aims: Patients on hemodialysis (HD) are at high risk of viral hepatitis due to high number of blood transfusion sessions, prolonged vascular access, high exposure to infected patients and contaminated equipment, or cross contamination from the dialysis circuits and pose problems in the management of patients in the renal dialysis units. This study was done to determine the prevalence of Hepatitis B virus (HBV) & Hepatitis C virus (HCV), in patients on hemodialysis in Zabeed City, Yemen Republic, and address the major risk factors for transmission of these viruses among HD patients. Materials and Methods: In this cross-sectional study, during June, 2013 to October, 2014, a total of 243 chronic hemodialysis patients were tested. Patients were selected from many regions by cluster sampling from Zabeed public hospital, (hemodialysis center) in Zabeed City, Yemen Republic. A close ended and multiple choice-based questionnaires were completed and HBsAg and anti-HCV antibodies were assessed using third generation enzyme linked immunoassay kit as serological testing and data were analyzed using the SPSS-20 software. Results: The overall prevalence of positive HBsAg was (48.83%) while positive anti-HCV was (46.01%) and (5.16%) mixed infection with HBV and HCV. Analysis of risk factors in patients with HBV & HCV infection is showed the history of blood transfusion and duration of hemodialysis was found to be a statistically significant (P < 0.05) as risk factor for HBV and HCV infection. Conclusion: The evaluation suggests that blood transfusion and duration of hemodialysis may be the main most important risk factor for HBV and HCV infection among hemodialysis patients.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

A. Al-Hegami, M. , Al-Mamari, A. , S. Al-Kadasse, A. , Al-Gasha’a, F. , Al-Hag, S. and Al-Hegami, A. (2015) Prevalence and Risk Factors of Hepatitis B and Hepatitis C Virus Infections among Patients with Chronic Renal Failure in Zabeed City, Yemen Republic. Open Journal of Medical Microbiology, 5, 136-142. doi: 10.4236/ojmm.2015.53017.

References

[1] Al Hijazat, M. and Ajlouni, Y. (2008) Hepatitis B Infection among Patients Receiving Chronic Hemodialysis at the Royal Medical Services in Jordan. Saudi Journal of Kidney Diseases and Transplantation, 19, 260-267.
[2] Boulaajaj, K., Elomari, Y. and Elmaliki, B. (2005) Prevalence of Hepatitis C, Hepatitis B and HIV Infection among Hemodialysis Patients in Ibn-Rochd University Hospital, Casablanca. Néphrologie & Thérapeutique, 1, 274-284.
http://dx.doi.org/10.1016/j.nephro.2005.06.012
[3] Chandra, M., Khaja, M.N. and Hussain, M.M. (2004) Prevalence of Hepatitis B and Hepatitis C Viral Infections in Indian Patients with Chronic Renal Failure. Intervirology, 47, 374-376.
[4] Dentico, P., Buogiorno, R. and Volpe, A. (1992) Prevalence and Incidence of Hepatitis C Virus (HCV) in Hemodialysis Patients: Study of Risk Factors. Clinical Nephrology, 38, 49-52.
[5] Elzouki, A., Esmeo, M., Samod, M., Abonaja, A., Alagi, B. and Daw, M. (2006) Prevalence of Hepatitis B, C and HIV Infection in Libya: A Population-Based Nationwide Seropepidemiological Study. Liver International, 26, 20.
[6] Reddy, G.A., Dakshinamurthy, K.V., Neelaprasad, P., Gangadhar, T. and Lakshmi, V. (2005) Prevalence of HBV and HCV Dual Infection in Patients on Haemodialysis. Indian Journal of Medical Microbiology, 23, 41-43.
http://dx.doi.org/10.4103/0255-0857.13872
[7] Telaku, S., Zekaj, S., Avdijaj, Xh., Elezi, Y., Kuqi, Xh., Zylfiu, B., Rudhani, I., Hasanxhekaj, V. and Fejza, H. (2003) Prevalence of Hepatitis B and C Infection in Dialysis Patient in Kosova. The Turkish Journal of Gastroenterology, 14, 106.
[8] Oguchi, H., Miyasaka, M. and Tokunaga, S. (1992) Hepatitis Virus Infection (HBV and HCV) in Eleven Japanese Hemodialysis Units. Clinical Nephrology, 38, 36-43.
[9] Otedo, A.E., Mc’Ligeyo, S.O. and Okoth, F.A. (2003) Seroprevalence of Hepatitis B and C in Maintenance Dialysis in a Public Hospital in a Developing Country. South African Medical Journal, 93, 380-384.
[10] El-kader, Y., El-Ottol, A., Elmanama, A.A. and Ayesh, B.M. (2010) Prevalence and Risk Factors of Hepatitis B and C Viruses among Hemodialysis Patients in Gaza Strip, Palestine. Virology Journal, 7, 210.
http://dx.doi.org/10.1186/1743-422X-7-210
[11] Qadi, A.A., Tamim, H., Ameen, G., Bu-Ali, A., Al-Arrayed, S., Fawaz, N.A. and Almawi, W.Y. (2004) Hepatitis B and Hepatitis C Virus Prevalence among Dialysis Patients in Bahrain and Saudi Arabia: A Survey by Serologic and Molecular Methods. American Journal of Infection Control, 32, 493-495.
http://dx.doi.org/10.1016/j.ajic.2003.12.009
[12] Alavian, S.M., Bagheri-Lankarani, K., Mahdavi-Mazdeh, M. and Nourozi, S. (2008) Hepatitis B and C in Dialysis Units in Iran: Changing the Epidemiology. Hemodialysis International, 12, 378-382.
http://dx.doi.org/10.1111/j.1542-4758.2008.00284.x
[13] Ozer, A., Yakupogullari, Y., Beytur, A., Beytur, L., Koroglu, M., Salman, F. and Aydogan, F. (2011) Risk Factors of Hepatitis B Virus Infection in Turkey: A Population-Based, Case-Control Study: Risk Factors for HBV Infection. Hepatitis Monthly, 11, 263-268.
[14] Abu El Makarem, M.A., Abdel Hamid, M., Abdel Aleem, A., Ali, A., Shatat, M., Sayed, D., Deaf, A., Hamdy, L. and Tony, E.A. (2012) Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients from Egypt with or without Hepatitis C Virus Infection. Hepatitis Monthly, 12, 253-258.
http://dx.doi.org/10.5812/hepatmon.5805
[15] Joukar, F., Besharati, S., Mirpour, H. and Mansour-Ghanaei, F. (2011) Hepatitis C and Hepatitis B Seroprevalence and Associated Risk Factors in Hemodialysis Patients in Guilan Province, North of Iran: HCV and HBV Seroprevalence in Hemodialysis Patients. Hepatitis Monthly, 11, 178-181.
[16] Zahedi, M.J., Moghaddam, S.D., Alavian, S.M. and Dalili, M. (2012) Seroprevalence of Hepatitis Viruses B, C, D and HIV Infection among Hemodialysis Patients in Kerman Province, South-East Iran. Hepatitis Monthly, 12, 339-343.
http://dx.doi.org/10.5812/hepatmon.5969
[17] Santos, M.G., Danguilan, R.A., Que, E.T., Balmaceda, R.P. and Padilla, B.S. (1998) Prevalence of Hepatitis B and Hepatitis C in Hemodialysis Patients. Nephrology, 4, 101-104.
http://dx.doi.org/10.1046/j.1440-1797.1998.d01-6.x
[18] Wang, C., Sun, J. and Zhu, B. (2010) Hepatitis B Virus Infection and Related Factors in Hemodialysis Patients in China-Systemic Review and Meta-Analysis. Renal Failure, 32, 1255-1264.
http://dx.doi.org/10.3109/0886022X.2010.517354
[19] Fejza, H. and Telaku, S. (2009) Prevalence of HBV and HCV among Blood Donors in Kosova. Virology Journal, 13, 6-21.
[20] Te, H.S. and Jensen, D.M. (2010) Epidemiology of Hepatitis B and C Viruses: A Global Overview. Clinics in Liver Disease, 14, 1-21.
http://dx.doi.org/10.1016/j.cld.2009.11.009
[21] Taal, M.W. and van Zyl-Smit, R. (2000) Hepatitis C Virus Infection in Chronic Hemodialysis Patients-Relationship to Blood Transfusions and Dialyzer Re-Use. South African Medical Journal, 90, 621-625.
[22] Almawi, W.Y., Qadi, A.A., Tamim, H., Ameen, G., Bu-Ali, A., Arrayid, S. and Abou Jaoude, M.M. (2004) Seroprevalence of Hepatitis C Virus and Hepatitis B Virus among Dialysis Patients in Bahrain and Saudi Arabia. Transplantation Proceedings, 36, 1824-1826.
http://dx.doi.org/10.1016/j.transproceed.2004.07.019

  
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