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Nuclear Features in the Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma—The Diagnostic Dilemma

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DOI: 10.4236/ijohns.2015.44051    2,746 Downloads   3,095 Views  

ABSTRACT

Aim: Follicular variant of papillary thyroid carcinoma [FVPC] as a diagnostic entity has been beset by many controversies. In this study, we describe the nuclear features essential for the diagnosis and analyze the difficulties that confront pathologists as it is important to avoid pitfalls because appropriate management protocol depends upon on an accurate diagnosis of this variant. Materials and Methods: A total of 30 cases, diagnosed as FVPC over a period of two years in the Department of Pathology, were taken for the study. Haematoxylin and Eosin stained sections were reviewed. The extent and distribution of nuclear features were analyzed. Results: The 30 cases of FVPC were categorized into encapsulated and infiltrative groups basing on the presence or lack of capsule and capsular invasion and vascular invasion. Conclusion: FVPC is diagnosed basing on specific nuclear features and hence histopathology still remains the gold standard for the accurate diagnosis.

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Padmavathi Devi, C. , Maruthi Devi, K. , Venugopal, M. and Partha Akarsh, M. (2015) Nuclear Features in the Diagnosis of Follicular Variant of Papillary Thyroid Carcinoma—The Diagnostic Dilemma. International Journal of Otolaryngology and Head & Neck Surgery, 4, 296-302. doi: 10.4236/ijohns.2015.44051.

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