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Modifications of L-Glutamine and L-Leucine Transport in Proliferating Lymphocytes

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DOI: 10.4236/jbm.2015.33016    3,170 Downloads   3,484 Views   Citations

ABSTRACT

Lymphocytes respond to mitogens that stimulate proliferation by increasing theirs metabolic activity. In this study we investigate L-Glutamine and L-Leucine uptake as markers of cell response to Concavalina A (ConcaA) stimulation, using a high-resolution flow technique. We found that lymphocytes induced to blast transformation enhanced rate and efficiency of amino acid uptake during cell proliferation. Considering that increases in transport is the first quantifiable response of cells during malignant transformation, amino acid uptake could also be useful as an early marker of malignancy.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Sanchez, F. , Gil, J. and Perán, M. (2015) Modifications of L-Glutamine and L-Leucine Transport in Proliferating Lymphocytes. Journal of Biosciences and Medicines, 3, 104-109. doi: 10.4236/jbm.2015.33016.

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