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Stereoselective Aldol Reaction in Aqueous Solution Using Prolinamido-Glycosides as Water-Compatible Organocatalyst

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DOI: 10.4236/mrc.2015.41003    4,876 Downloads   5,497 Views   Citations

ABSTRACT

Prolinamido-glycoside catalyzed asymmetric aldol reaction in aqueous media is reported. The reactions are rapid and highly stereoselective when water is used as solvent. The stereoselectivities were under influence of configurations of a prolyl residue of the catalyst and α-chiral aldehydes. Water soluble prolinamido-glycoside catalysts are easily separable from reaction mixture and can be recycled and re-used several times.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Miura, D. and Machinami, T. (2015) Stereoselective Aldol Reaction in Aqueous Solution Using Prolinamido-Glycosides as Water-Compatible Organocatalyst. Modern Research in Catalysis, 4, 20-27. doi: 10.4236/mrc.2015.41003.

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