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Broad Antibacterial Activity of Bothrops jararaca Venom against Bacterial Clinical Isolates

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DOI: 10.4236/aim.2014.416127    2,194 Downloads   2,617 Views  

ABSTRACT

Purpose: To evaluate the antibacterial activity of Bothrops jararaca venom against bacterial clinical isolates. Methods: Antibacterial activity of Bothrops jararaca venom was evaluated through agar diffusion method against the following bacteria: Acinetobacter baumannii, Oxacillinase-producing Acinetobacter baummanii, extended-spectrum β-lactamase-producing (ESBL) Enterobacter aerogenes, Escherichia coli, Escherichia coli ESBL, Klebsiella pneumoniae, Klebsiella pneumoniae ESBL, Proteus mirabilis, Pseudomonas aeruginosa, metallo β-lactamase-producing Pseudomonas aeruginosa, Staphylococcus aureus, oxacillin resistant Staphylococus aureus (ORSA), Staphylococcus epidermidis, and oxacillin resistant Staphylococus epidermidis. Minimum inhibitory concentration was determined through microdilution plate protocol. Results: The venom presented antibacterial activity against all tested bacteria. More pronounced results were observed to Gram- positive bacteria, especially against ORSA. Conclusion: The present study evidenced the great antibacterial potential of Bothrops jararaca venom showing promising results even with resistant bacterial clinical isolates.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Cendron, L. , Bertol, C. , Fuentefria, D. , Calegari, E. , Dallegrave, E. , Moura, D. , Moura, K. , Marques, M. and Rossato, L. (2014) Broad Antibacterial Activity of Bothrops jararaca Venom against Bacterial Clinical Isolates. Advances in Microbiology, 4, 1174-1187. doi: 10.4236/aim.2014.416127.

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