The Effect of Selenium and Lycopene on Oxidative Stress in Bone Tissue in Rats Exposed to Cadmium

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DOI: 10.4236/fns.2014.514155    2,438 Downloads   2,802 Views  


This study examined the effect of selenium (Se) or lycopene (Lyc) and their combination on oxidative stress in bone following cadmium (Cd) exposure in vivo. Cd exposure enhanced accumulation of Cd in femur with subsequent increase in LPO and PC and decreased antioxidative enzyme activities in rat femur, along with significant decreases in body and femur bone weights. Subcutaneous (s.c.) injection of Se or Lyc reduced Cd accumulation in bone and increased body and femur weights,when given individually or concomitantly. Antioxidant enzyme activities maintained and/or increased following Se and Lyc supplementation when given individually or concomitantly. However, lycopene dose of 10 mg/kg of body weight alone or selenium alone provided better protection to bone tissues of rats against oxidative stress compared to treatment with their combination. Selenium and lycopene could be used as a dietary supplement to protect against bone oxidative stress in areas exposed to Cd pollution.

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Ibrahim, T. , Tarboush, H. , Aljada, A. and Mohanna, M. (2014) The Effect of Selenium and Lycopene on Oxidative Stress in Bone Tissue in Rats Exposed to Cadmium. Food and Nutrition Sciences, 5, 1420-1429. doi: 10.4236/fns.2014.514155.


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