ABC> Vol.4 No.4, June 2014
Review Paper

Promising Efficacy of the Cola acuminata Plant: A Mini Review

DownloadDownload as PDF (Size:355KB)  HTML   XML  PP. 240-245  

ABSTRACT

Cola acuminata also known as the bissy nut extract was originally endemic to Africa but is now present in a number of tropical countries including Jamaica. Despite its rich history of ethnomedicinal use and promising bioactivity, there still exists limited research on this plant. Exploring and compiling the ethnomedicinal usage, identified bioactivities and isolates of C. acuminata will prove useful in steering future directional research with the hope of reaping the plant’s full beneficial properties. The plant’s traditional use encompass; cancer treatment, an antidote for poisoning, suppressing one’s appetite, increasing alertness, treating migraine and motion sickness, obtaining a state of euphoria in addition to being used in certain traditional practices. Because of the plant’s copious ethnomedicinal use, researchers were led to believe that the low incidence of prostate cancer evidenced amongst Asians could be as a result of phytochemicals present in the bissy nut. Research conducted in our lab confirmed the anti-cancer potential of the plant and recent research has identified a number of secondary metabolites present in C. acuminata which could be responsible for the observed bioactivities. The plant has also shown promise as an anti-microbial agent. This paper confirms the efficacy of the bissy nut plant both as an ethnomedicine as well as warranting further research that may prove useful both in the pharmaceutical and nutraceutical industries.

Cite this paper

Lowe, H. , Watson, C. , Badal, S. , Peart, P. , Toyang, N. and Bryant, J. (2014) Promising Efficacy of the Cola acuminata Plant: A Mini Review. Advances in Biological Chemistry, 4, 240-245. doi: 10.4236/abc.2014.44029.

References

[1] Mitchell, S. and Ahmad, M. (2006) A Review of Medicinal Plant Research at the University of the West Indies, Jamaica, 1948-2001. West Indies Medical Journal, 55, 243-269.
[2] Krippner, S. (2003) Models of Ethnomedicinal Healing. Ethnomedicine Conferences, Munich, 26-27 April and 11-12 October.
[3] Lowe, H., Payne-Jackson, A., Beckstrom-Sternberg, S., et al. (2000) Jamaica’s Ethnomedicine: Potential in the Healthcare System. University of the West Indies, Kingston, 170.
[4] Gordaliza, M. (2007) Natural Products as Leads to Anticancer Drugs. Clinical & Translational Oncology, 9, 767-776.
http://dx.doi.org/10.1007/s12094-007-0138-9
[5] Williams, L. (2006) Ethnomedicine. The West Indian Medical Journal, 55, 215-216.
http://dx.doi.org/10.1590/S0043-31442006000400001
[6] Odebunmi, E., Oluwaniyi, O., Awolola, G., et al. (2008) Proximate and Nutritional Composition of Kola Nut (Cola nitida), Bitter Cola (Garcinia cola) and Alligator Pepper (Afromomum melegueta). African Journal of Biotechnology, 8, 308-310.
[7] Duke, J. (1989) CRC Handbook of Nuts. CRC Press, Inc., Boca Raton.
[8] Adam, S., Yahya, A., Salih, W., et al. (2011) Antimicrobial Activity of the Masticatory Cola acuminata Nut (Gooro). Current Research Journal of Biological Sciences, 3, 357-362.
[9] Lowe, H., Payne-Jackson, A., Beckstrom-Sternberg, S.M., et al. (2001) Jamaica’s Ethnomedicine. Pelican Publishers, Kingston.
[10] Russell, T.A. (1995) The Kola of Nigeria and the Cameroons. Tropical Agriculture (Trinidad), 32, 210-240.
[11] Fossella, F.V., DeVore, R., Kerr, R.N., et al. (2000) Randomized Phase III Trial of Docetaxel Versus Vinorelbine or Ifosfamide in Patients With Advanced Non-Small-Cell Lung Cancer Previously Treated With Plati-num-Containing Chemotherapy Regimens Journal of Clinical Oncology, 18, 2354-2362.
[12] Rosengarten, F. (1984) The Book of Edible Nuts. Walker and Company, New York.
[13] Ayodele, E.A. (1995) Physico-Chemical Properties of Some Kola (Cola nitida) Growing Soils of Nigeria. Nigeria Journal of Tree Crop Research, 1, 37-51.
[14] Benjamin, L.T., Rogers, A.M. and Rosenbaum, A. (1991) Cocacola, Caffeine, and Mental Deficiency: Harry Hollingworth and the Chattanooga Trial of 1991. Nigeria Journal of Tree Crop Research, 27, 42-45.
http://dx.doi.org/10.1002/1520-6696(199101)27:1<42::AID-JHBS2300270105>3.0.CO;2-1
[15] Sonibare, M., Soladoye, M., Esan, O., et al. (2009) Phytochemical and Antimicrobial Studies of four Species Cola Schott & Ednl. (Sterculiaceae). African Journal of Traditional, Complementary, and Alternative, 6, 518-525.
[16] Endrini, S., Jaska, S., Marsiati, H., et al. (2011) Effects of Cola Nut (Cola nitida) on the Apoptotic Cell of Human Breast Carcinoma Cell Lines. Journal of Medicinal Plants Research, 5, 2393-2397.
[17] Natural Standard (2012) Kola Nut (Cola acuminata).
http://www.naturalstandard.com/index-abstract.asp?create-abstract=colanut.asp&title=Kola%20nut
[18] Warner, M. (2007) Herbal Plants of Jamaica. Macmillan Caribbean, Thailand, 94-95.
[19] Odebunmi, E., Oluwaniyi, O., Awoloa, G., et al. (2009) Proximate and Nutritional Composition of Kola Nut (Cola nitida), Bitter Cola (Garcinia cola) and Alligator Pepper (Afromomum melegueta). African Journal of Biotechnology, 8, 308-310.
[20] Mitchell, S. (2003) Bissy, Bissy, Bissy. The Jamaica Gleaner, Kingston.
http://jamaica-gleaner.com/gleaner/20030226/health/health4.html
[21] Cragg, G. and Newman, D. (2005) Plants as a Source of Anti-Cancer Agents. Journal of Ethnopharmacology, 100, 72-79.
http://dx.doi.org/10.1016/j.jep.2005.05.011
[22] Lowe, H., Watson, C., Badal, S., et al. (2012) Cytotoxic Effect of Jamaican Bissy Nut Extracts on Various Cancer Cell Lines. Applied Cell Biology, 1, 47-49.
[23] Fontenot, K., Naragoni, S., Claville, M., et al. (2007) Characterization of Bizzy Nut Extracts in Estrogen-Responsive MCF-7 Breast Cancer Cells. Toxicology and Applied Pharmacology, 220, 25-32.
http://dx.doi.org/10.1016/j.taap.2006.12.012
[24] Solipuram, R., Koppula, S., Hurst, SA., et al. (2009) Molecular and Biochemical Effects of Kola Nut Extract on Androgen Receptor-Mediated Pathways. Journal of Toxicology, 2009, 1-16.
http://dx.doi.org/10.1155/2009/530279
[25] Koyama, J. (2006) Anti-Infective Quinone Derivatives of Recent Patents. Recent Patents on Anti-infective Drug Discovery, 1, 113-125.
http://dx.doi.org/10.2174/157489106775244073
[26] Cho, S.H., Lee, S., Kim, J., et al. (1995) Development and Application of Natural Antimicrobial Agents Isolated 6 from Grape-Fruit Seeds Extract, Antimicrobial Activities of Grape Fruit Extract. Journal of Food Hygiene and Safety, 10, 33-39.
[27] Smid, E.J. and Gorris, G. (1999) Natural Antimicrobials for Food Preservation. Handbook of Food Preservation, Marcel Dekker, New York.
[28] Nychas, G.J.E. (1995) Natural Antimicrobial from Plants. In: Gould, G.W., Ed., New Methods of Food Preservation, CRC Press, London, 235-258.
[29] Tassou, C., Drosinos, E. (1997) Wak Antimicrobial Effect of Carob (Ceratonia siliqua) Extract against Food-Related Bacteria in Culture Media and Model Food System. World Journal of Microbiology & Biotechnology, 13, 479-481.
http://dx.doi.org/10.1023/A:1018544821143
[30] Odugbemi, T. (2006) Outlines and Pictures of Medicinal plants from Nigeria. University of Lagos Press, Lagos, 158.
[31] Ajarem, J. and Ahmad, M. (1994) Effect of Consumption of Fresh Kola-Nut Extract by Female Mice on the Post-Natal Development and Behaviour of Their Offspring. Journal of King Saudi University, 6, 41-50.
[32] Ajarem, J. (1990) Effects of Fresh Kola-Nut Extract (Cola nitida) on the Locomotor Activities of Male Mice. Acta Physiologica et Pharmacologica Bulgarica, 16, 10-15.
[33] Shehu, S., Sonfada, M., Danmaigoro, A., et al. (2012) Kola Nut (Cola acuminata) Extract as a Substitute to Histological Tissue Stain Eosin. Scientific Journal of Veterinary Advances, 1, 33-37.
[34] Adeyeye, E., Asaolu, S. and Aluko, A. (2007) Amino Acid Composition of Two Masticatory Nuts (Cola acuminata and Garcinia kola) and a Snack Nut (Anacardium occidentale). International Journal of Food Sciences and Nutrition, 58, 241-249.
http://dx.doi.org/10.1080/09637480701486108
[35] Atawodi, S., Pfundstein, B., Haubner, R., et al. (2007) Content of Polyphenolic Compounds in Nigerian Stimulants Cola nitida ssp. alba, Cola nitida ssp. rubra, A. chev, and Cola acuminate Schott & Endl and Their Antioxidant Capacity. Journal of Agricultural and Food Chemistry, 55, 9824-9828.
http://dx.doi.org/10.1021/jf0721038

  
comments powered by Disqus

Copyright © 2014 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.