Geometrical study on diseaserelated ncRNAs based on Z-curve method

Yan-Ling Yang, Ji-Hua Wang

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DOI: 10.4236/health.2009.11005                

Abstract

The Z curve is a very useful method for visual-izing and analyzing DNA sequences. It is a three-dimensional space curve that constitutes a unique representation of a given DNA se-quence. It becomes more and more important to study non-coding regions in the recent years. Using Z curve method, 15 disease-related ncRNAs and some snoRNAs and miRNAs sequences are selected from the NONCODE database in this paper, which relate to Alzheimer Disease. The corresponding Z curves of the studied ncRNAs, sequences have been mapped and compared. The statistical features of the Z curves are ob-tained. These features indicate that the ncRNAs sequences playing same roles in the celluar process have almost the same Z-curves. And the base content in these sequences is almost same too.

Keywords

Non-CodingRNA; Alzheimer Disease; snoRNA; miRNA; Z-Curve

Conflicts of Interest

The authors declare no conflicts of interest.

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