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A General Model for Hepatitis B Disease with Age-Dependent Susceptibility and Transmission Probabilities

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DOI: 10.4236/am.2014.54068    4,169 Downloads   6,492 Views  


A SEI model for hepatitis B is constructed where the susceptibility and other crucial transmission probabilities depend on the chronological age and the basic reproduction rate R0 is derived. Under suitable (biological and mathematical) assumptions in a closed population, results of Houpa D. D. E. et al. [1] are extended from constant case of p and q to age-dependent case: the disease-free equilibrium is globally asymptotically stable (GAS) if R0 < 1. On the other hand, R0 > 1 induces that endemic equilibrium is GAS and the system is uniformly persistent.

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Houpa, D. , Miamdjo, T. and Kouakep, T. (2014) A General Model for Hepatitis B Disease with Age-Dependent Susceptibility and Transmission Probabilities. Applied Mathematics, 5, 707-722. doi: 10.4236/am.2014.54068.


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