Health> Vol.6 No.1, January 2014

Common infection and allergy induced biomarkers status in respiratory diseases among Iranian Hajj pilgrims

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ABSTRACT

Background: The sources of respiratory disorders commonly occurred during the Hajj ceremony are now challenging and its infectious or allergic nature remained unknown. The present comprehensive study was conducted to assess sources of respiratory disorders in Hajj pilgrims. Method: In this prospective observational study, blood samples of 130 pilgrims were taken for assessment of serum levels of infectious and allergic sources. The measurement of IgA, IgG, IgM was used for assessment of infectious reactions against microbial antigens, NBT test was employed to assess phagocytic functions, and the measurement of gamma interferon was used for assessing immunity status against infections. Also, measurement of IgE and IL-4 was applied as two markers for assessing allergic reactions. The ELISA test was also used to assess serum levels of immunoglobulin A, G, M, E, IL-4 and gamma interferon before and three weeks after returning from Hajj ceremony. All of the volunteers were followed up along the trip and the involved pilgrim’s characteristics were recorded. Results: The present study showed no significant change in the level of allergic biomarkers including IgE and IL-4, however the mean levels of IgM, gamma Interferon and NBT test were increased after the trip compared with before that. Conclusion: Infections play a major role in occurrence of respiratory disorders among Hajj pilgrims and thus the role of allergic sources is doubtful.

Cite this paper

Razavi, S. , Masoud, A. , Ardakani, H. and Dabiran, S. (2014) Common infection and allergy induced biomarkers status in respiratory diseases among Iranian Hajj pilgrims. Health, 6, 137-140. doi: 10.4236/health.2014.61021.

References

[1] [1] Meysamie, A., Ziaee Ardakani, H., Razavi, S.M. and Doroodi, T. (2006) Comparison of mortality and morbidity rates among Iranian pilgrims in Hajj 2004 and 2005. Saudi Medical Journal, 27, 447-451.
[2] Balkhy, H.H., Memish, Z.A., Bafaqeer, S. and Almuneef, M.A. (2004) Influenza, a common viral Infection among Hajj pilgrims. Journal of Travel Medicine, 11, 82-87.
http://dx.doi.org/10.2310/7060.2004.17027
[3] Razavi, S.M., Ziaee, H., Mokhtari, A.T., Hamkar, R., Doroodi, T., Mirsalehian, A., Nakhjavan, F., Nejat, F., Sadeghipoor, H., Masoud, A., Kordbacheh, P., Zeini, F., Saf Ara, M., Mirafshar, M., Bamdad, K. and Bazarjani, F. (2007) Surveying respiratory infections among Iranian Hajj pilgrims. Iranian Journal of Clinical Infectious Diseases, 2, 67-70.
[4] Memish, Z.A., Venkatesh, S. and Ahmed, Q.A. (2003) Travel epidemiology: The Saudi perspective. International Journal of Antimicrobial Agents, 21, 96-101.
[5] Kordbacheh, P., Zeyni, F., Ziaee, H., Mohammad, K., Razavi, S.M., et al. (2006) Mycotic flora of the Iranian pilgrim’s physical environment and their role in occurrence of respiratory diseases during Hajj 2004. Journal of Faculty Medicine TUMS, 12.
[6] (2005) Annual report of the medical board of Islamic Republic of Iran’s Red Crescent in Hajj.
[7] Al-Harthi, A.S. and Al-Harbi, M. (2004) Accidental injuries during Muslim pilgrimage. Saudi Medical Journal, 25, 4-11.
[8] Gray, P.W. and Goeddel, D.V. (1982) Structure of the human immune interferon gene. Nature, 298, 859-763.
http://dx.doi.org/10.1038/298859a0
[9] Schoenborn, J.R. and Wilson, C.B. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Advances in Immunology, 96, 41-101.
http://dx.doi.org/10.1016/S0065-2776(07)96002-2
[10] Anderson, D.P., Moritomo, T. and de Grooth, R. (1992) Neutrophil, glass-adherent, nitroblue tetrazolium assay gives early indication of immunization effectiveness in rainbow trout. Veterinary Immunology and Immunopathology, 30, 419-429.
[11] Abbas, A.K. and Lichtman, A.H. (2003) Cellular and molecular immunology. 5th Edition, Saunders, Philadelphia.
[12] Kuby, J. (2006) Immunology. 3rd Edition, W.H. Freeman and Company, New York.
[13] Birdsal, H.H. (2010) Antibodies. In: Mandell, Douglas, and Bennett’s principles and practice of Infectious diseases. 7th Edition, Vol. 1, Churchill Livingstone, 59-62.
http://dx.doi.org/10.1016/B978-0-443-06839-3.00006-0
[14] Chretien, J.H. and Garagusi, V.F. (1971) Suppressed reduction of Nitro Blue Tetrazolium by Poly Morpho Nuclear neutrophils from patients receiving steroids. Cellular and Molecular Life Sciences, 27, 1343.
http://dx.doi.org/10.1007/BF02136729
[15] Robinson, C.M., O’Dee, D., Hamilton, T. and Nau, G.J. (2009) Cytokines involved in interferon-gamma production by human macrophages. Journal of Innate Immunity, 2, 56-65. http://dx.doi.org/10.1159/000247156
[16] Leonard, B.E. and Song, C. (1996) Stress and the immune system in the etiology of anxiety and depression. Pharmacology, Biochemistry and Behavior, 54, 299-304.
http://dx.doi.org/10.1016/0091-3057(95)02158-2

  
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