Synthesis, Characterization, Anti-Bacterial and Anti-Fungal Activities of New Quinoxaline 1,4-di-N-Oxide Derivatives

Dalia Hussein Soliman

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

DOI: 10.4236/ijoc.2013.33A007                

Abstract

A new series of quinoxaline 1,4-di-N-oxides were synthesized and evaluated for their antibacterial and antifungal activities. The best result was demonstrated by 3-amino-N-(4-methoxyphenyl)-2-quinoxalinecarboxamide 1,4-di-N-oxide 4e, MIC (0.24 μg/ml) against Aspergillus fumigatus, and (0.12 μg/ml) against Streptococcus pneumonia.

Keywords

Quinoxaline 1, 4-di-N-Oxide; Beirut Reaction; Benzofuroxanes; β-Ketoamide; β-Cyanoamide; Antibacterial; Antifungal

Conflicts of Interest

The authors declare no conflicts of interest.

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