Effect of Temperature on Separation of Sarin (GB) Ions in Differential Mobility Spectrometry

Miroslaw Maziejuk, Michal Ceremuga, Monika Szyposzyńska, Tomasz Sikora

Wojskowy Instytut Chemii i Radiometrii, Warszawa, Poland.

DOI: 10.4236/ojpc.2013.34021                

Abstract

Different environmental conditions in which, equipment based on differential ion mobility spectrometry must operate, forced designers and engineers to analyze the impact of, among other things, external factors on their performance and efficiency. These devices, thanks to the DMS technology, can identify and characterize the ions contained in the gaseous state. However, many areas of this technique remain undiscovered, which should be examined in more detail. One such aspect is the influence of the temperature of gaseous medium, containing tested analyte. The research presented in this article shows why temperature is an important factor on the distribution of generated peaks. The results are shown for different spectra generated carrier gas temperatures (50°C - 80°C) in which ions were toxic warfare agents. Based on those graphs, it can be stated that increase of the temperature allows for better separation of the peaks from the background. Because of the similar ion mobility of the analyte and background ions for high and low electric field, DMS device can send false alarms, due to the poor interpretations of passing a signal to them. So to be able to accurately assess the level of risk due to the presence of substances BST in air, the test medium was added to isobutanol and isopropanol additives. They help better analyze and separate measured ions.

Keywords

DMS; Spectrometry; Ion Mobility

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	N. Krylova, E. Krylov, G. A. Eiceman and J. A. Stone, “Effect of Moisture on the Field Dependence of Mobility for Gas-Phase Ions of Organophosphorus Compounds at Atmospheric Pressure with Field Asymmetric Ion Mobility Spectrometry,” The Journal of Physical Chemistry, Vol. 107, No. 19, 2003, pp. 3648-3654. http://dx.doi.org/10.1021/jp0221136
[2]	I. A. Burakov, “Express Analysis of Explosives, Chemical Warfare Agents and Drugs with Multicapillary Column Gas Chromatography and Ion Mobility Increment Spectrometry,” Journal of Chromatography B, Vol. 800, No. 1-2, 2004, pp. 75-82. http://dx.doi.org/10.1016/j.jchromb.2003.10.064
[3]	G. R. Asury, C. Wu, W. F. Siems and H. H. Hill Jr., “Separation and Identification of Some Chemical Warfare Degradation Products Using Electrospray High Resolution Ion Mobility Spectrometry with Mass Selected Detection,” Analytica Chimica Acta, Vol. 404, No. 2, 2000, pp. 273-283. http://dx.doi.org/10.1016/S0003-2670(99)00726-6
[4]	M. Maziejuk and W. Harmata, “Publikacja: Spektrometr Ruchliwosci Jonów jako Element Ukladów do Wykrywania Wysokotoksycznych Substancji Chemicznych,” Przemysl Chemiczny, Vol. 11, 2006, p. 1495
[5]	J. A. Creese and H. J. Cooper, “Separation and Identification of Isomeric Glycopeptides by High Field Asymmetric Waveform Ion Mobility Spectrometry,” Analytical Chemistry, Vol. 84, No. 5, 2012, pp. 2597-2601. http://dx.doi.org/10.1021/ac203321y
[6]	E. V. Krylov, E. G. Nazarov and R. A. Miller, “Differential Mobility Spectrometer: Model of Operation,” International Journal of Mass Spectrometry, Vol. 266, No. 1-3, 2007, pp. 76-85. http://dx.doi.org/ 10.1016/j.ijms.2007.07.003
[7]	A. A. Shvartsburg, “Differential Ion Mobility Spectrometry: Nonlinear Ion Transport and Fundamentals of FAIMS,” CRC Press, Boca Raton, 2009.
[8]	A. A. Shvartsburg, Y. Zheng, R. D. Smith and N. L. Kelleher, “Separation of Variant Methylated Histone Tails by Differential Ion Mobility,” Analytical Chemistry, Vol. 84, No. 15, 2012, pp. 6317-6320. http://dx.doi.org/10.1021/ac301541r
[9]	B. B. Schneider, T. R. Covey, S. L. Coy, V. Krylov and E. G. Nazarov, “Planar Differential Mobility Spectrometer as a Pre-Filter for Atmospheric Pressure Ionization Mass Spectrometry,” International Journal of Mass Spectrometry, Vol. 298, No. 1-3, 2010, pp. 45-54. http://dx.doi.org/10.1016/j. ijms.2010.01.006
[10]	M. Ceremuga, M. Maziejuk, M. Szyposzyńska and S. Szmidt, “Publikacja: Identyfikacja Somanu za Pomoca Róznicowego Spektrometru Ruchliwosci Jonów,” Przemysl Chemiczny, Vol. 92, No. 1, 2013, p. 55.
[11]	A. A. Shvartsburg, F. Li, K. Tang and R. D. Smith, “High-Resolution Field Asymmetric Waveform Ion Mobility Spectrometry Using New Planar Geometry Analyzers,” Analytical Chemistry, Vol. 78, No. 11, 2006, pp. 3706-3714. http://dx.doi.org/10.1021/ac052020v
[12]	A. A. Aksenov, J. Kapron and C. E. Davis, “Predicting Compensation Voltage for Singly-Charged Ions in High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS),” Journal of the American Society for Mass Spectrometry, Vol. 23, No. 10, 2012, pp. 1794-1798. http://dx.doi.org/10.1007/s 13361-012-0427-6
[13]	E. V. Krylov, S. L. Coy and E. G. Nazarov, “Temperature Effects in Differential Mobility Spectrometry,” International Journal of Mass Spectrometry, Vol. 279, No. 2-3, 2009, pp. 119-125. http://dx.doi.org/ 10.1016/j.ijms.2008.10.025
[14]	M. Maziejuk, “Róznicowa Spektrometria Ruchliwosci Jonów,” Wydawnictwo WAT, Warszawa, 2012.
[15]	M. Jakubowska, M. Maziejuk, M. Ceremuga, J. Siczek and W. Gallewicz, “Ceramic DMS-Type Detector,” International Journal for Ion Mobility Spectrometry, Vol. 15, No. 3, 2012, pp. 99-108. http://dx.doi.org/10.1007/s12127-012-0093-1