The COP9 Signalosome Controls Adipocyte Differentiation by Regulating CHOP Protein Stability

Xiaohua Huang, Wolfgang Dubiel

Department of General, Visceral, Vascular and Thoracic Surgery, Division of Molecular Biology, Charité - Universit?tsmedizin Berlin, Berlin, Germany.

DOI: 10.4236/eng.2012.410B050                

Abstract

Obesity is a serious health problem of our time. Dysfunction of adipogenesis, the differentiation of adipocytes, is a hallmark of obesity. Therefore here we investigate the role of the COP9 signalosome and of CHOP in the differentiation of LiSa-2 preadipocytes.

Keywords

COP9 Signalosome; CHOP; Adipogenesis; Cullin-RING Ubiquitin Ligase

Conflicts of Interest

The authors declare no conflicts of interest.

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