Renewing Oncological Hyperthermia—Oncothermia

Abstract

Hyperthermia was the very first oncotherapy in human medicine, but its applicability in modern oncology was dubious. The discovery of electromagnetism gave new hope a century ago, however, until up to now, it has been suffering from lack of wide acceptance. Oncological hyperthermia suffers from multiple unsolved medical and technical problems. The accurate selection of malignant tissue and its proper heating in depth are real challenges together with the control and repeatability of the treatments. However, the center of the problems is not technical: the living system tries to keep its homeostatic equilibrium and creates active feedback mechanisms to eliminate or at least correct the constrain heating in depth. The proper reaction on the “gage of battle” has to involve the physiology, handle it complexly together with bioelectromagnetism and update connected technology. The solution has to be the integration of the natural bio-effects into the technological constrains, acting in synergy with the physiological feedback mechanisms, and without forcing effects out of the homeostatic control. The solution lies in strict selection and adequate action in nanoscopic range, without exciting the robust transport-mechanisms to operate against the energy delivery to the tumor. Together with the local optimization, the systemic effects have to be considered, because malignancy is not a local disease. This concept needs interactions with the immune-system being effective on the disseminated cell in far distance too. Our objective is to present a complex technical solution to this complex problem.

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Szasz, O. (2013) Renewing Oncological Hyperthermia—Oncothermia. Open Journal of Biophysics, 3, 245-252. doi: 10.4236/ojbiphy.2013.34030.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] D. Granmt, “The Galvano-Cautery in the Treatment of In-tra-Laryngeal Growths,” The Journal of Laryngology Rhinology and Ontology, Vol. 19, No. 6, 1904, pp. 294- 297. http://dx.doi.org/10.1017/S1755146300174633
[2] H. H. LeVeen, S. Wapnick, V. Piccone et al., “Tumor Eradication by Radiofrequency Therapy,” JAMA, Vol. 235, No. 20, 1976, pp. 2198-2200. http://dx.doi.org/10.1001/jama.1976.03260460018014
[3] M. Abe, M. Hiraoka, M. Takahashi, et al., “Multi-Institutional Studies on Hyperthermia Using an 8-MHz Radiofrequency Capacitive Heating Device (Thermotron RF- 8) in Combination with Radiation for Cancer Therapy,” Cancer, Vol. 58, No. 8, 1986, pp. 1589-1595. http://dx.doi.org/10.1002/1097-0142(19861015)58:8<1589::AID-CNCR2820580802>3.0.CO;2-B
[4] M. Hiraoka, S. Jo, K. Akuta, et al., “Radiofrequency Capacitive Hyperthermia for Deep-Seated Tumors—I. Studies on Thermometry,” Cancer, Vol. 60, No. 1, 1987, pp. 121-127. http://dx.doi.org/10.1002/1097-0142(19870701)60:1<121::AID-CNCR2820600123>3.0.CO;2-I
[5] C. K. Lee, C. W. Song, J. G. Rhee, et al., “Clinical Experience Using 8 MHz Radiofrequency Capacitive Hyperthermia in Combination with Radio-therapy: Results of a Phase I/II Study,” International Journal of Radiation Oncology*Biology*Physics, Vol. 32, No. 3, 1995, pp. 733-745.
[6] P. F. Turner, “Regional Hyperthermia with an Annular Phase Array,” IEEE Transactions on Biomedical Engineering, Vol. 31, No. 1, 1984, pp. 106-111. http://dx.doi.org/10.1109/TBME.1984.325376
[7] P. Wust, H. Fahling and W. Wlodarczyk, “Antenna Arrays in the Sig-ma-Eye Applicator: Interactions and Transforming Networks,” Medical Physics, Vol. 28, No. 8, 2001, pp. 1793-1805. http://dx.doi.org/10.1118/1.1388220
[8] J. R. Oleson, “A Review of Magnetic Induction Methods for Hyperthermia Treatment of Cancer,” Biomedical Engineering, Vol. 31, No. 1, 1984, pp. 91-97.
[9] K. Maier-Hauff, F. Ulrich, D. Nestler, H. Niehoff, P. Wust, B. Thiesen, H. Orawa, V. Budach and A. Jordan, “Efficacy and Safety of Intratumoral Thermotherapy Using Magnetic Iron-Oxide Nanoparticles Combined with External Beam Radiotherapy on Patients with Recurrent Glioblastoma Multiform,” Journal of Neurooncology, Vol. 103, No. 2, 2011, pp. 317-324. http://dx.doi.org/10.1007/s11060-010-0389-0
[10] M. Heckel, “Ganzkorperhyperthermie und Fiebertherapie —Grundlagen und Praxis,” Hippokrates, Stuttgart, 1990.
[11] A. Von Ardenne and H. Wehner, “Extreme Whole-Body Hyperthermia with Water-Filtered Infrared—A Radiation,” Eurekah Bioscience Collection, Oncology, Landes Bioscience, 2005.
[12] S. Osinsky, V. Ganul, V. Protsyk, et al., “Local and Regional Hyperthermia in Combined Treatment of Malignant Tumors: 20 Years Experience in Ukraine,” The Kadota Fund International Forum 2004, Awaji, 15-18 June 2004.
[13] J. Gellermann, W. Wlodarczyk, B. Hildebrandt, H. Ganter, A. Nicolau, B. Rau, W. Tilly, H. Fahling, J. Nadobny, R. Felix and P. Wust, “Noninvasive Magnetic Resonance Thermography of Recurrent Rectal Carcinoma in a 1.5 Tesla Hybrid System,” Cancer Research, Vol. 65, No. 13, 2005, pp. 5872-5880. http://dx.doi.org/10.1158/0008-5472.CAN-04-3952
[14] P. Wust, B. Hildebrandt, G. Sreenivasa, B. Rau, J. Gellermann, H. Riess, R. Felixand and P. M. Schlag, “Hyperthermia in Combined Treatment of Cancer,” Lancet Oncology, Vol. 3, No. 8, 2002, pp. 487-497. http://dx.doi.org/10.1016/S1470-2045(02)00818-5
[15] J. Gellerman, “Nichtinvasive Thermometrie bei Lokoregionaler Tiefenhyperthermie,” Hyperthermia Seminar, Cologne, 2006.
[16] W. Wlodarczyk, P. Wust, M. Seebass, J. Gellermann and J. Nadobny, “Recent Advances in Technology and Tech- nique of RF Hyperthermia,” 2012. www.ursi.org/Proceedings/ProcGA02/papers/p0835.pdf
[17] J. van der Zee, “Radiotherapy and Hyperthermia in Cervical Cancer,” Presentation on Conference in Mumbai India,2005.
[18] T. Hasegawa, Y.-H. Gu, T. Takahashi, T. Hasegawa and I. Yamamoto, “Enhancement of Hyperthermic Effects Using Rapid Heating,” In: M. Kosaka, T. Sugahara, K. L. Schmidt and E. Simon, Eds., Thermotherapy for Neoplasia, Inflammation, and Pain, Springer Verlag, Tokyo- Berlin, 2001, pp. 439-444. http://dx.doi.org/10.1007/978-4-431-67035-3_49
[19] A. M. Stoll, “Heat Transfer in Biotechnology,” In: J. P. Hartnett and T. F. Irvine, Eds., Advances in Heat Transfer, Academic Press Inc., New York, London, 1967, pp. 65- 139.
[20] T. E. Cooper and G. J. Trezek, “Correlation of Thermal Properties of Some Human Tissue with Water Content,” Aerospace Medicine, Vol. 42, No. 1, 1971, pp. 24-27.
[21] A. Szasz, O. Szasz and N. Szasz, “Oncothermia: Principles and Practices,” Springer, Heidelberg, 2010.
[22] A. Szasz, “Challenges and Solutions in Oncological Hyperthermia,” Thermal Medicine, Vol. 29, No. 1, 2012, pp. 1-23. http://dx.doi.org/10.3191/thermalmed.29.1
[23] A. Szasz, “Local Hyperthermia in Oncology,” In: N. Huilgol, Ed., Hyperthermia, InTech, Morn Hill, 2013. http://dx.doi.org/10.5772/52208
[24] O. Szasz, “Essentials of Oncothermia,” Conference Papers in Medicine, Vol. 2013, 2013, Article ID: 159570.
[25] A. Szasz, Gy. Vincze, O. Szasz and N. Szasz, “An Energy Analysis of Extracellular Hyperthermia,” Magneto- and Electro-Biology, Vol. 22, No. 2, 2003, pp. 103-115.
[26] K. E. Stine, “Energy Metabolism and Cancer.” http://personal.ashland.edu/kstine/Research/Energy%20and%20disease.pdf
[27] K. Garber, “Energy Boost: The Warburg Effect Returns in a New Theory of Cancer,” Journal of the National Cancer Institute USA, Vol. 96, No. 24, 2004, pp. 1805- 1806. http://dx.doi.org/10.1093/jnci/96.24.1805
[28] O. Warburg, “On the Origin of Cancer Cells,” Science, Vol. 123, No. 3191, 1956, pp. 309-314. http://dx.doi.org/10.1126/science.123.3191.309
[29] M. C. Raff, “Social Controls on Cell Survival and Death,” Nature, Vol. 356, No. 6368, 1992, pp. 397-400. http://dx.doi.org/10.1038/356397a0
[30] L. Kopfstein and G. Christofori, “Metastasis: Cell-Autonomous Mechanisms versus Contributions by the Tumor Microenvironment,” Cellular and Molecular Life Sciences, Vol. 63, No. 4, 2006, pp. 449-468. http://dx.doi.org/10.1007/s00018-005-5296-8
[31] R. Damadian, “Tumor Detection by Nuclear Magnetic Resonance,” Science, Vol. 171, No. 3976, 1971, pp. 1151- 1153. http://dx.doi.org/10.1126/science.171.3976.1151
[32] C. F. Hazlewood, D. C. Chang, D. Medina, et al., “Distinction between the Preneoplastic and Neoplastic State of Murine Mammary Glands,” Proceedings of the National Academy of Sciences USA, Vol. 69, No. 6, 1972, pp. 1478- 1480. http://dx.doi.org/10.1073/pnas.69.6.1478
[33] D. Wirtz, K. Konstantopoulos and P. C. Searson, “The Physics of Cancer: The Role of Physical Interactions and Mechanical Forces in Metastasis,” Nature Reviews Cancer, Vol. 11, No. 7, 2011, pp. 512-523. http://dx.doi.org/10.1038/nrc3080
[34] M. Yang and W. J. Brackenbury, “Membrane Potential and Cancer Progression,” Frontiers in Physiology, Vol. 4, 2013, pp. 185-195. http://dx.doi.org/10.3389/fphys.2013.00185
[35] B. T. Chernet and M. Levin, “Transmembrane Voltage Potential Is an Essential Cellular Parameter for the Detection and Control of Tumor Development in a Xenopusmodel,” Disease Models and Mechanisms, Vol. 6, No. 3, 2013, pp. 595-607. http://dx.doi.org/10.1242/dmm.010835
[36] A. d’Onofrio, “Fractal Growth of Tumors and Other Cellular Populations: Linking the Mechanistic to the Phenomenological Modeling and Vice Versa,” Chaos, Solitons and Fractals, Vol. 41, No. 2, 2009, pp. 875-880. http://dx.doi.org/10.1016/j.chaos.2008.04.014
[37] Gy. Vincze and A. Szasz, “On the Extremum Properties of Thermodynamic Steady State in Non-Linear Systems” In: J. C. Moreno-Pirajan, Ed., Thermodynamics—Physical Chemistry of Aqueous Systems, InTech Open, Morn Hill, 2011, pp. 241-316. http://cdn.intechopen.com/pdfs/20162/InTech-On_the_extrmum_properties_of_thermodynamic_steady_state_in_non_linear_systems.pdf
[38] A. Szasz, Gy. Vincze, O. Szasz and N. Szasz, “An Energy Analysis of Extracellular Hyperthermia,” Magneto- and Electro-Biology, Vol. 22, No. 2, 2003, pp. 103-115.
[39] A. K. Datta and J. Liu, “Thermal Time Distributions for Microwave and Conventional Heating of Food,” Transactions of the Institution of Chemical Engineers, Vol. 70, 1992, pp. 83-90.
[40] A. K. Datta and W. Hu, “Quality Optimization of Dielectric Heating Processes,” Food Technology, Vol. 46, No. 12, 1992, pp. 53-56.
[41] S. Salengke and S. K. Sastry, “Experimental Investigation of Ohmic Heating of Solid-Liquid Mixtures under Worst- Case Heating Scenarios,” Journal of Food Engineering, Vol. 83, No. 3, 2007, pp. 324-336. http://dx.doi.org/10.1016/j.jfoodeng.2007.02.060
[42] A. Szasz, N. Szasz and O. Szasz, “Oncothermia—Principles and Practice,” Springer Verlag, Heidelberg, 2010.
[43] A. Szasz and T. Morita, “Heat Therapy in Oncology—Oncothermima. New Paradigm in Hyperthermia,” 2012.
[44] A. Szasz, N. Iluri and O. Szasz, “Oncothermia—To Choose or Not to Choose?” Oncotherm Group Publication, 2012.
[45] G. S. Yablonsky, A. N. Gorban, D. Constales, V. V. Galvita, G. B. Marin, “Reciprocal Relations between Kinetic Curves,” Europhysics Letters, Vol. 93, No. 2, 2011, 20004. http://dx.doi.org/10.1209/0295-5075/93/20004
[46] T. Y. Tsong and C.-H. Chang, “Ion Pump as Brownian Motor: Theory of Electroconformational Coupling and Proof of Ratchet Mechanism for Na,K-ATPase Action,” Physica A: Statistical Mechanics and Its Applications, Vol. 321, No. 1, 2003, pp. 124-138. http://dx.doi.org/10.1016/S0378-4371(02)01793-4
[47] G. Andocs, Y. Okamoto, K. Kawamoto, T. Osaki, T. Tsuka, T. Imagawa, S. Minami, L. Balogh, N. Meggyeshazi and O. Szasz, “Oncothermia Basic Research at in Vivo Level. The First Results in Japan,” Conference Papers in Medicine, Vol. 2013, 2013, Article ID: 197328. http://dx.doi.org/10.1155/2013/197328
[48] G. Andocs, N. Meggyeshazi, Y. Okamoto, L. Balogh and O. Szasz, “Bystander Effect of Oncothermia,” Conference Papers in Medicine, Vol. 2013, 2013, Article ID: 953482. http://dx.doi.org/10.1155/2013/953482
[49] N. Meggyeshazi, G. Andocs and T. Krenacs, “Programmed Cell Death Induced by Modulated Electro-Hyperthermia,” Conference Papers in Medicine, Vol. 2013, 2013.
[50] N. Meggyeshazi, G. Andocs, S. Spisák and T. Krenács, “Early Changes in mRNA and Protein Expression Related to Cancer Treatment by Modulated Electro-Hyperthermia,” Conference Papers in Medicine, Vol. 2013, 2013, Article ID: 249563. http://dx.doi.org/10.1155/2013/249563

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