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Multifaceted role of TNF-α during the pathogenesis of rheumatoid arthritis

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DOI: 10.4236/abb.2013.410123    2,122 Downloads   3,663 Views   Citations

ABSTRACT

Tumor necrosis factor alpha (TNF-α) a cytokine has been shown to be the key player during the pathogenesis of several autoimmune inflammatory disorders (presumably sterile inflammation) including rheumatoid arthritis (RA). Several studies have shown that TNF-α is mainly involved in the proinflammatory responses. However recent studies have reported multifunctional role of TNF-α during the development of RA. Therefore, in this article we have highlighted the distinct functions of TNF-α during pathogenesis of RA.  

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Mula, R. and Shashidharamurthy, R. (2013) Multifaceted role of TNF-α during the pathogenesis of rheumatoid arthritis. Advances in Bioscience and Biotechnology, 4, 937-940. doi: 10.4236/abb.2013.410123.

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