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Isolation and Characterization of R-Enantiomer in Ezetimibe

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DOI: 10.4236/ajac.2013.49062    4,163 Downloads   5,829 Views   Citations

ABSTRACT

A simple and rapid Supercritical Fluid Chromatography (SFC) method has been developed to isolate and characterize R-Isomer of Ezetimi be by using normal phase Chiral Cel OD-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbondi oxide (Co2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated R-Isomer is characterized by using UV-vis, FT-IR, ESI-MS, HPLC1H and 13C NMR. The purity of isolated R-Isomer is about 98%.

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K. Chimalakonda, V. Kamani, M. Gutta, S. Polisetty and S. Srinivas Koduri, "Isolation and Characterization of R-Enantiomer in Ezetimibe," American Journal of Analytical Chemistry, Vol. 4 No. 9, 2013, pp. 488-495. doi: 10.4236/ajac.2013.49062.

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