The Effects of Insulin Resistance and Inflammation on Renal Proximal Tubule Sodium Transport and Hypertension

Abstract

Insulin resistance, closely linked to inflammation, is recognized as a key factor in the onset and aggravation of diabetes, cardio-renal syndrome, hypertension, and obesity. In the renal proximal tubule, insulin resistance may increase renal sodium reabsorption, leading to hypertension, edema and sometimes heart failure. Recently some anti-diabetic agents have been shown to have effects on the transporters in renal proximal tubule. Because renal proximal tubule mediates about 70% of sodium reabsorption, it is quite important to clarify the function of renal proximal tubule under insulin resistance and inflammation.

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S. Horita, M. Nakamura, M. Suzuki, H. Yamada and G. Seki, "The Effects of Insulin Resistance and Inflammation on Renal Proximal Tubule Sodium Transport and Hypertension," Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 5A, 2013, pp. 34-41. doi: 10.4236/ojemd.2013.35A003.

Conflicts of Interest

The authors declare no conflicts of interest.

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