Plasma reference value of heart-type fatty acid-binding protein, the earliest available plasma biomarker of acute myocardial infarction

Download Download as PDF (Size:299KB)  HTML    PP. 1206-1209  


More rapid triaging of patients suspected for acute myocardial infarction (AMI) is needed to facilitate early initiation of appropriate therapy in patients with AMI and to exclude low-risk patients who can safely be sent home. Heart-type fatty acid-binding protein (H-FABP) is established to be the earliest available plasma marker for AMI diagnosis. There is a paucity of data on circulating levels of H-FABP in the general population. In this study we applied a H-FABP immunoassay with improved analytical performance to assess plasma H-FABP reference values in a relatively large group (n = 443) of healthy subjects aged 18-69 y. Mean (±SD) plasma H-FABP concentration was 1.7 ± 0.9 ng/mL, with somewhat higher values found in males than in females. Plasma H-FABP also increases with age, as previously reported. The 99th centile was obtained for subjects aged 41-69 years and amounted to 5.6 ng/mL.

Cite this paper

Glatz, J. and Mohren, R. (2013) Plasma reference value of heart-type fatty acid-binding protein, the earliest available plasma biomarker of acute myocardial infarction. Health, 5, 1206-1209. doi: 10.4236/health.2013.58163.


[1] Hamm, C.W., Bassand, J.-P., Agewall, S., Bax, J., Boersma, E., Bueno, H., Caso, P., Dudek, D., Gielen, S., Huber, K., Ohmann, M., Petrie, M.C., Sonntag, F., Sousa Uva, M., Storey, R.F., Wijns, W. and Zahger, D. (2011) ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. European Heart Journal, 32, 2999-3054. doi:10.1093/eurheartj/ehr236
[2] Pelsers, M.M.A.L., Chapelle, J.P., Knapen, M., Vermeer, C., Muijtjens, A.M.M., Hermens, W.T. and Glatz, J.F.C. (1999) Influence of age and sex and day-to-day and within-day biological variation on plasma concentrations of fatty acid-binding protein and myoglobin in healthy subjects. Clinical Chemistry, 45, 441-443.
[3] Haltern, G., Peiniger, S., Bufe, A., Reiss, G., Gülker, H. and Scheffold, T. (2010) Comparison of usefulness of heart-type fatty acid binding protein versus cardiac troponin T for diagnosis of acute myocardial infarction. American Journal of Cardiology, 105, 1-9. doi:10.1016/j.amjcard.2009.08.645
[4] Kurz, K., Giannitsis, E., Becker, M., Hess, G., Zdunek, D. and Katus, H.A. (2011) Comparison of the new high sensitivity cardiac troponin T with myoglobin, h-FABP and cTnT for early identification of myocardial necrosis in the acute coronary syndrome. Clinical Research in Cardiology, 100, 209-215. doi:10.1007/s00392-010-0230-y
[5] Viswanathan, K., Kilcullen, N., Morrell, C., Thistlethwaite, S.J., Sivananthan, M.U., Hassan, T.B., Barth, J.H. and Hall, A.S. (2010) Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutive patients with suspected acute coronary syndrome who are troponin-negative. Journal of the American College of Cardiology, 55, 2590-2598. doi:10.1016/j.jacc.2009.12.062
[6] Lippi, G., Mattiuzzi, C. and Cervellin, G. (2013) Critical review and meta-analysis on the combination of heart-type fatty acid binding protein (H-FABP) and troponin for early diagnosis of acute myocardial infarction. Clinical Biochemistry, 46, 26-30. doi:10.1016/j.clinbiochem.2012.10.016
[7] Ruff, C.T., Bonaca, M.P., Kosowsky, J.M., Conrad M.J., Murphy, S.A., Jarolim P., Donahoe, S.M., O’Donoghue, M.L. and Morrow, D.A. (2013) Evaluation of the diagnostic performance of heart-type fatty acid binding protein in the BWH-TIMI ED chest pain study. Journal of Thrombosis and Thrombolysis, in press. doi:10.1007/s11239-013-0870-7
[8] Niizeki, T., Takeishi, Y., Takabatake, N., Shibata, Y., Konta, T., Kato, T., Kawata, S. and Kubota, I. (2007) Circulating levels of heart-type fatty acid-binding protein in a general Japanese population: Effects of age, gender and physiological characteristics. Circulation Journal, 71, 1452-1457. doi:10.1253/circj.71.1452
[9] Bathia, D.P., Carless, D.R., Viswanathan, K., Hall, A.S. and Barth, J.H. (2009) Serum 99th centile values for two heart-type fatty acid binding protein assays. Annals of Clinical Biochemistry, 46, 464-467. doi:10.1258/acb.2009.009055
[10] Carless, D.R., Wnek, M., Knox, C., Harrison, K.R., Calder, N., Hall, A.S. and Barth, J.H. (2013) Clinical and analytical evaluation of an immunoturbidimetric heart-type fatty acid-binding protein assay. Scandinavian Journal of Clinical & Laboratory Investigation, 73, 48-53. doi:10.3109/00365513.2012.734396
[11] Wodzig, K.W.H., Pelsers, M.M.A.L., Van der Vusse, G.J., Roos, W. and Glatz, J.F.C. (1997) One-step enzyme-linked immunosorbent assay (ELISA) for plasma fatty acid-binding protein. Annals of Clinical Biochemistry, 34, 263-268.
[12] Roos, W., Eymann, E., Symannek, M., Duppenthaler, J., Wodzig, K.W.H., Pelsers, M.M.A.L. and Glatz, J.F.C. (1995) Monoclonal antibodies to human heart fatty acid-binding protein. Journal of Immunological Methods, 183, 149-153. doi:10.1016/0022-1759(95)00043-A
[13] Bruins Slot, M.H.E., Reitsma, J.B., Rutten, F.H., Hoes, A.W. and Van der Heijden, G.J.M.G. (2010) Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction: A systematic review and metaanalysis. Heart, 96, 1957-1963. doi:10.1136/hrt.2010.208272
[14] Viswanathan, K., Hall, A.S. and Barth, J.H. (2012) An evidence-based approach to the assessment of heart-type fatty acid binding protein in acute coronary syndrome. Clinical Biochemistry Review, 33, 3-11.
[15] Tate, J.R. (2008) Troponin revisited 2008: Assay performance. Clinical Chemistry and Laboratory Medicine, 46, 1489-1500. doi:10.1515/CCLM.2008.292

comments powered by Disqus

Sponsors, Associates, and Links >>


Copyright © 2016 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.