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Biological sources of L-DOPA: An alternative approach

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DOI: 10.4236/apd.2013.23016    7,275 Downloads   14,408 Views   Citations


Parkinson’s disease was first formally identified by British physician James Parkinson in 1817 as “The Shaking Palsy”. L-DOPA (3,4-dihydroxy-phenyl-L-alanine) has been considered as a gold-standard treatment for Parkinson’s disease. The world market for L-DOPA is about 250 t/year and the total market volume is about $101 billion per year. The present review summarizes the different biological sources for the production of L-DOPA. The process for L-DOPA production from different biological sources has advantages over the chemical methods such as, enantiometrically pure L-DOPA, less incubation time and cost effective method. L-DOPA is found naturally in certain plant foods, particularly broad beans which found to replenish brain levels of L-DOPA even more quickly, and for longer periods, than conventional medication.

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A. Patil, S. , Apine, O. , Surwase, S. and Jadhav, J. (2013) Biological sources of L-DOPA: An alternative approach. Advances in Parkinson's Disease, 2, 81-87. doi: 10.4236/apd.2013.23016.


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