IJCM> Vol.4 No.7, July 2013
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A Case Study of Gut Fermentation Syndrome (Auto-Brewery) with Saccharomyces cerevisiae as the Causative Organism

ABSTRACT

Gut Fermentation Syndrome also known as Auto-Brewery Syndrome is a relatively unknown phenomenon in modern medicine. Very few articles have been written on the syndrome and most of them are anecdotal. This article presents a case study of a 61 years old male with a well documented case of Gut Fermentation Syndrome verified with glucose and carbohydrate challenges. Stool cultures demonstrated the causative organism as Saccharomyces cerevisiae. The patient was treated with antifungals and a low carbohydrate diet and the syndrome resolved. Helicobacter pylori was also found and could have been a possible confounding variable although the symptoms resolved post-treatment of the S. cerevisiae.

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Cite this paper

B. Cordell and J. McCarthy, "A Case Study of Gut Fermentation Syndrome (Auto-Brewery) with Saccharomyces cerevisiae as the Causative Organism," International Journal of Clinical Medicine, Vol. 4 No. 7, 2013, pp. 309-312. doi: 10.4236/ijcm.2013.47054.

References

[1] K. Iwata, “A Review of the Literature on Drunken Syndromes Due to Yeasts in the Gastrointestinal Tract,” University of Tokyo Press, Tokyo, 1972, pp. 260-268.
[2] H. Kaji, Y. Asanuma, H. Ide, N. Saito, M. Hisamura, M. Murao, T. Yoshida and K. Takahashi, “The Auto-Brewery Syndrome—The Repeated Attacks of Alcoholic Intoxication Due to the Overgrowth of Candida (Albicans) in the Gastrointestinal Tract,” Materia Medica Polona, Vol. 4, No. 29, 1976, pp. 429-435.
[3] A. Dahshan and K. Donovan, “Auto-Brewery Syndrome in a Child with Short Gut Syndrome: Case Report and Review of the Literature,” Journal of Pediatric Gastroenterology and Nutrition, Vol. 33, No. 2, 2001, pp. 214215. doi:10.1097/00005176-200108000-00024
[4] E. Jansson-Nettelbladt, S. Meurling, B. Petrini and J. Sjolin, “Endogenous Ethanol Fermentation in a Child with Short Bowel Syndrome,” Acta Paediatrica, Vol. 95, No. 4, 2006, pp. 502-504.
[5] A. Hunnisett and J. Howard, “Gut Fermentation (or the ‘Auto-Brewery’) Syndrome: A New Clinical Test with Initial Observations and Discussion of Clinical and Biochemical Implications,” Journal of Nutritional Medicine, Vol. 1, No. 1, 1990, pp. 33-39. doi:10.3109/13590849009003132
[6] K. Eaton, “Gut Fermentation: A Reappraisal of an Old Clinical Condition with Diagnostic Tests and Management: Discussion Paper,” Journal of the Royal Society of Medicine, Vol. 84, No. 11, 1991, pp. 669-671.
[7] A. Al-Awadhi, I. Wasfi, F. Al-Reyami and Z. Al-Hatali, “Autobrewing Revisited: Endogenous Concentrations of Blood Ethanol in Residents of the United Arab Emirates,” Science and Justice, Vol. 44, No. 3, 2004, pp. 149-152. doi:10.1016/S1355-0306(04)71707-4
[8] S. Fleming, D. Marthinsen and H. Kuhnlein, “Colonic Function and Fermentation in Men Consuming High Fiber Diets,” Journal of Nutrition, Vol. 113, No. 12, 1983, pp. 2535-2544. http://jn.nutrition.org/content/113/12/2535.full.pdf+html?sid=ca1b1840-1887-4cc6-936d-1844793aa52c
[9] S. Rao, C. Edwards, C. Austen, C. Bruce and N. Read, “Impaired Colonic Fermentation of Carbohydrate after Ampicillin,” Gastroenterology, Vol. 94, No. 4, 1988, pp. 928-932.
[10] J. Sauer, K. Richter and B. Pool-Zobel, “Products Formed during Fermentation of the Prebiotic Inulin with Human Gut Flora Enhance Expression of Biotransformation Genes in Human Primary Colon Cells,” British Journal of Nutrition, Vol. 97, No. 5, 2007, pp. 928-938. doi:10.1017/S0007114507666422
[11] W. Bivin and B. Heinen, “Production of Ethanol from Infant Food Formulas by Common Yeasts,” Journal of Applied Bacteriology, Vol. 58, No. 4, 1985, pp. 355-357. doi:10.1111/j.1365-2672.1985.tb01473.x
[12] A. Enache-Angoulvant and C. Hennequin, “Invasive Saccharomyces Infection: A Comprehensive Review,” Clinical Infectious Diseases, Vol. 41, No. 11, 2005, pp. 15591568. doi:10.1086/497832
[13] P. Munoz, E. Bouza, M. Cuenca-Estrella, J. Eiros, M. Perez, M. Sanchez-Somolinos, C. Rincon, J. Horta and T. Pelaez, “Saccharomyces cerevisiae Fungemia: An Emerging Infectious Disease,” Clinical Infectious Diseases, Vol. 40, No. 11, 2005, pp. 1625-1634. doi:10.1086/429916
[14] A. Riquelme, M. Calvo, A. Guzman, et al., “Saccharomyces cerevisiae Fungemia after Saccharomyces boulardii Treatment in Immunocompromised Patients,” Journal of Clinical Gastroenterology, Vol. 36, No. 1, 2002, pp. 41-43. doi:10.1097/00004836-200301000-00013
[15] W. Olver, S. James, A. Lennard, A. Galloway, T. Roberts, T. Boswell and N. Russell, “Nosocomial Transmission of Saccharomyces cerevisiae in Bone Marrow Transplant Patients,” Journal of Hospital Infection, Vol. 52, No. 4, 2002, pp. 268-272. doi:10.1053/jhin.2002.1314
[16] J. Perapoch, A. Planes, A. Querol, V. Lopez, I. MartinezBendayan, R. Tormo, F. Fernandez, G. Peguero and S. Salcedo, “Fungemia with Saccharomyces cerevisiae in Two Newborns, Only One of Whom Had Been Treated with Ultra-Levura,” European Journal of Clinical Microbiology and Infectious Diseases, Vol. 19, No. 6, 2000, pp. 468-470. doi:10.1007/s100960000295

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