Parental Consanguinity in Infertile Males

Abdullah Demirtas, Emre Can Akinsal, Oguz Ekmekcioglu

Department of Urology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

DOI: 10.4236/oju.2013.32010                

Abstract

This study was investigated whether parental consanguinity in males has an effect on or relationship with some infertile subgroups and some semen and hormone parameters. The charts of 2651 infertile males were evaluated retrospectively for parental consanguinity ratios, sperm counts, motility parameters and hormonal values from the records of 2651 infertile males. In 1260 eligible males the first cousin parental consanguinity ratio was 22.6%. In 119 males with nonobstructive azoospermic (NOA) and 430 males with normal sperm counts, the ratios were 34.5% and 20.9%, respectively (p = 0.002). In the NOA group the parental consanguinity ratios were 27.1% (23/85) and 52.9% (18/34) in males with FSH values of >7.6 and <7.6 mIU/ml, respectively (p = 0.007). In males with normal sperm counts if the parents were first cousins, both sperm counts and motility parameters were significantly reduced when compared with the others. To our knowledge, this is the first study of consanguinity ratios among some infertile subgroups. In males with parental consanguinity lower sperm counts and motility ratios in normozoospermic males and lower FSH levels in the NOA group might show a relation with some genetically transmitted defects.

Keywords

Azoospermia; Genetics; Male Infertility; Parental Consanguinity

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	M. C. Inhorn, L. Kobeissi, Z. Nassar, D. Lakkis and M. H. Fakih, “Consanguinity and Family Clustering of Male Factor Infertility in Lebanon,” Fertility and Sterility, Vol. 91, No. 4, 2009, pp. 1104-1109. doi:10.1016/j.fertnstert.2008.01.008
[2]	J. Zlotogora, “Genetic Disorders among Palestinian Arabs: 1. Effects of consanguinity,” American Journal of Medical Genetics, Vol. 68, No. 4, 1997, pp. 472-475. doi:10.1002/(SICI)1096-8628(19970211)68:4<472::AID-AJMG20>3.0.CO;2-O
[3]	A. H. Bittles, J. C. Grant, S. G. Sullivan and R. Hussain, “Does Inbreeding Lead to Decreased Human Fertility?” Annals of Human Biology, Vol. 29, No. 2, 2002, pp. 111-130. doi:10.1080/0301 4460110075657
[4]	B. Baccetti, S. Capitani, G. Collodel, G. Di Cairano, L. Gambera, E. Moretti and P. Piomboni, “Genetic Sperm Defects and Consanguinity,” Human Reproduction, Vol. 16, No, 7, 2001, pp. 1365-1371. doi:10.1093/humrep/16.7.1365
[5]	D. Escalier and M. Albert, “New Fibrous Sheath Anomaly in Spermatozoa of Men with Consanguinity,” Fertility and Sterility, Vol. 86, No. 1, 2006, pp. e211-e219. doi:10.1016/j.fertnstert.2005.12.042
[6]	F. Lanfranco, A. Kamischke, M. Zitzmann and E. Nieschlag, “Klinefelter’s Syndrome,” Lancet, Vol. 364, No. 9430, 2004, pp. 273-283. doi:10.1016/S0140-6736(04)16678-6
[7]	J. L. Simpson, F. de la Cruz, R. S. Swerdloff, C. Samango-Sprouse, N. E. Skakkebaek, J. M. Graham, et al., “Klinefelter Syndrome: Expanding the Phenotype and Identifying New Research Directions,” Genetics in Medicine: Official Journal of the American College of Medical Genetics, Vol. 5, No. 6, 2003, pp. 460-468.
[8]	M. Fromantin, J. Gineste, A. Didier and J. Rouvier, “Impuberism and Hypogonadism at Induction into Military service. Statistical Study,” Problemes Actuels d’Endocrinologie et de Nutrition, Vol. 3, No. 16, 1973, pp. 179-199.
[9]	F. Brioude, J. Bouligand, S. Trabado, B. Francou, S. Salenave, P. Kamenicky, et al., “Non-Syndromic Congenital Hypogonadotropic Hypogonadism: Clinical Presentation and Genotype-Phenotype Relationships,” European Journal of Endocrinology/European Federation of Endocrine Societies, Vol. 162, No. 5, 2010, pp. 835-851.
[10]	N. Basaran, H. Hassa, A. Basaran, S. Artan, J. D. Stevenson and B. S. Sayli, “The Effect of Consanguinity on the Reproductive Wastage in the Turkish Population,” Clinical Genetics, Vol. 36, No. 3, 1989, pp. 168-173. doi:10.1111/j.1399-0004.1989.tb03183.x
[11]	E. Tuncbilek and I. Koc, “Consanguineous Marriage in Turkey and Its Impact on Fertility and Mortality,” Annals of human Genetics, Vol. 58, No. 4, 1994, pp. 321-329. doi:10.1111/j.1469-1809.1994.tb00729.x