Quality of Life (QOL) in Long-Term Survivors of Osteosarcoma

Abstract

We conducted this study to analyze the quality of life using the SF-36 health questionnaire and the MSTS scores depending on surgical method and the primary site of occurrence. On the surgical method, the limb salvage had more excellent outcomes (60.9) than the amputation (46.3). The tumor prosthetic replacement had notably higher scores (62.5) than any other methods. For the correlation coefficients on the MSTS and SF-36, the Physical Function had the highest degree of correlation. Excellent functions of the extremities would lead to a good quality of life.

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J. Kim, J. Kwak and S. Chung, "Quality of Life (QOL) in Long-Term Survivors of Osteosarcoma," Journal of Cancer Therapy, Vol. 4 No. 1, 2013, pp. 133-137. doi: 10.4236/jct.2013.41018.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] J. S. Whelan, et al., “Osteosarcoma,” European Journal of Cancer, Vol. 33, No. 10, 1997, pp. 1611-1619. doi:10.1016/S0959-8049(97)00251-7
[2] T. Yonemoto, S. Tatezaki, T. Ishii, T. Satoh, H. Kimura and N. Iwai, “Prognosis of Osteosarcoma with Pulmonary Metastases at Initial Presentation Is Not Dismal,” Clinical Orthopaedics and Related Research, Vol. 349, 1998, pp. 194-199. doi:10.1097/00003086-199804000-00024
[3] T. Yonemoto, S. Tatezaki, T. Ishii, K. Osato and T. Takenouchi, “Long-Term Survival after Surgical Removal of Solitary Brain Metastasis from Osteosarcoma,” International Journal of Clinical Oncology, Vol. 8, No. 5, 2003, pp. 340-342. doi:10.1007/s10147-003-0341-9
[4] W. Enneking, et al., “Thirty Years of Limb Salvage,” La Chirurgia degliorgani di movimento, Vol. 88, No. 4, 2003, pp. 321-325.
[5] T. Yonemoto, S. Tatezaki and T. Ishii, “Knee Rotation-Plasty for Malignant Musculoskeletal Tumors Occurring around the Knee Joint,” Anticancer Research, Vol. 21, No. 1B, 2001, pp. 717-722.
[6] H. Tsuchiya, M. E. Abdel-Wanis and K. Tomita, “Biological Reconstruction after Excision of Juxta-Articular Osteosarcoma around the Knee: A New Classification System,” Anticancer Research, Vol. 26, No. 1B, 2006, pp. 447-453.
[7] T. Yonemoto, S. Tatezaki, T. Ishii, T. Satoh and M. Inoue, “Two Cases of Osteosarcoma Occurring as Second Malignancy of Childhood Cancer,” Anticancer Research, Vol. 19, No. 6C, 1999, pp. 5563-5566.
[8] T. Yonemoto, S. Tatezaki, T. Ishii and Y. Hagiwara, “Marriage and Fertility in Long-Term Survivors of High Grade Osteosarcoma,” American Journal of Clinical Oncology, Vol. 26, No. 5, 2003, pp. 513-516. doi:10.1097/01.coc.0000037666.38888.A5
[9] T. Yonemoto, S. Tatezaki, T. Ishii, Y. Hagiwara and M. Inoue, “Multiple Primary Cancers in Patients with Osteosarcoma: The Influence of Anticancer Drugs and Genetic Factors,” American Journal of Clinical Oncology, Vol. 27, No. 3, 2004, pp. 220-224. doi:10.1097/01.COC.0000054534.43117.76
[10] W. F. Enneking, W. Dunham, M. C. Gebhardt, M. Malawar and D. J. Pritchard, “A System for the Functional Evaluation of Reconstructive Procedures after Surgical Treatment of Tumors of the Musculoskeletal System,” Clinical Orthopaedics and Related Research, Vol. 286, 1993, pp. 241-246.
[11] A. J. Renard, R. P. Veth, H. W. Schreuder, C. J. van Loon, H. S. Koops and J. R. van Horn, “Function and Complications after Ablative and Limb-Salvage Therapy in Lower Extremity Sarcoma Of Bone,” Journal of Surgical Oncology, Vol. 73, No. 4, 2000, pp. 198-205. doi:10.1002/(SICI)1096-9098(200004)73:4<198::AID-JSO3>3.0.CO;2-X
[12] R. Nagarajan, J. P. Neglia, D. R. Clohisy and L. L. Robison, “Limb Salvage and Amputation in Survivors of Pediatric Lower-Extremity Bone Tumors: What Are the Long-Term Implications?” Journal of Clinical Oncology, Vol. 20, No. 22, 2002, pp. 4493-4501. doi:10.1200/JCO.2002.09.006
[13] P. J. Pakulis, N. L. Young and A. M. Davis, “Evaluating Physical Function in an Adolescent Bone Tumor Population,” Pediatric Blood & Cancer, Vol. 45, No. 5, 2005, pp. 635-643. doi:10.1002/pbc.20383
[14] R. Nagarajan, D. R. Clohisy, J. P. Neglia, Y. Yasui, P. A. Mitby, C. Sklar, J. Z. Finklestein, M. Greenberg, G. H. Reaman, L. Zeltzer and L. L. Robison, “Function and Quality-Of-Life of Survivors of Pelvic and Lower Extremity Osteosarcoma and Ewing’s Sarcoma: The Childhood Cancer Survivor Study,” British Journal of Cancer, Vol. 91, 2004, pp. 1858-1865. doi:10.1038/sj.bjc.6602220
[15] A. Postma, A. Kingma, J. H. De Ruiter, H. SchraffordtKoops, R. P. Veth, L. N. Goeken and W. A. Kamps, “Quality of Life in Bone Tumor Patients Comparing Limb Salvage and Amputation of the Lower Extremity,” Journal of Surgical Oncology, Vol. 51, No. 1, 1992, pp. 47-51. doi:10.1002/jso.2930510113
[16] B. T. Rougraff, M. A. Simon, J. S. Kneisl, D. B. Greenberg and H. J. Mankin, “Limb Salvage Compared with Amputation for Osteosarcoma of the Distal End of the Femur. A Long-Term Oncological, Functional, and Quality-Of-Life Study,” The Journal of Bone & Joint Surgery, Vol. 76A, No. 5, 1994, pp. 649-656.
[17] Y. Refaat, J. Gunnoe, F. J. Hornicek and H. J. Mankin, “Comparison of Quality of Life after Amputation or Limb Salvage,” Clinical Orthopaedics and Related Research, Vol. 397, 2002, pp. 298-305. doi:10.1097/00003086-200204000-00034
[18] A. Zahlten-Hinguranage, L. Bernd, V. Ewerbeck and D. Sabo, “Equal Quality of Life after Limb-Sparing or Ablative Surgery for Lower Extremity Sarcomas,” British Journal of Cancer, Vol. 91, No. 6, 2004, pp. 1012-1014.
[19] V. G. Marchese, S. Ogle, R. B. Womer, J. Dormans and J. P. Ginsberg, “An Examination of Outcome Measures to Assess Functional Mobility in Childhood Survivors of Osteosarcoma,” Pediatric Blood & Cancer, Vol. 42, No. 1, 2004, pp. 41-45. doi:10.1002/pbc.10462
[20] T. Akahane, T. Shimizu, K. Isobe, Y. Yoshimura, F. Fujioka and Kato H. , “Evaluation of Postoperative General Quality of Life for Patients with Osteosarcoma around the Knee Joint,” Journal of Pediatric Orthopaedics, Vol. 16, No. 4, 2007, pp. 269-272. doi:10.1097/BPB.0b013e3280925670
[21] C.-W. Han, E.-J. Lee, “Development of the Korean Version of Short-Form 36-Item Health Survey: Health Related QOL of Healthy Elderly People and Elderly Patients in Korea,” The Tohoku Journal of Experimental Medicine, Vol. 203, No. 3, 2004, pp. 189-194. doi:10.1620/tjem.203.189
[22] T. Yonemoto, T. Ishii, Y. Takeuchi, K. Kimura, Y. Hagiwara, S. Iwata and S.-I. Tatezaki, “Evaluation of Quality of Life (QOL) in Long-term Survivors of High-grade Osteosarcoma: A Japanese Single Center Experience,” Anticancer Research, Vol. 27, 2007, pp. 3621-3624.

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