Spectrum of imaging and characteristics for liver tumors treated with irreversible electroporation

Download Download as PDF (Size:2382KB)  HTML   XML  PP. 813-818  
DOI: 10.4236/jbise.2012.512A102    2,896 Downloads   4,837 Views   Citations

ABSTRACT

Therapeutic irreversible electroporation (IRE) is a relatively new technique for targeted tumor ablation. Needle electrodes are placed into or around the targeted region to deliver a series of brief electric pulses that disrupt cell membrane integrity, killing cells in a non-thermal manner that does not affect the extracellular matrix or sensitive structures such as major vasculature and bile ducts; making IRE an advantageous technique, especially for tumors that are unresectable or ineligible for thermal ablation. Here, we present on the imaging findings from IRE liver tumor treatments from ultrasound, computed tomography, magnetic resonance, and positron emission tomography. Imaging aids planning and implementing treatments by visualizing the targeted volume and guiding electrode placement. Immediate changes to the affected IRE region may be observed to verify complete ablation of the tumor with margin during the procedure, and permits follow-up evaluation of clinical outcome. In particular, we present tumor treatments in regions adjacent to sensitive structures that contraindicate thermal therapies.

Cite this paper

Neal II, R. , Cheung, W. , Kavnoudias, H. and Thomson, K. (2012) Spectrum of imaging and characteristics for liver tumors treated with irreversible electroporation. Journal of Biomedical Science and Engineering, 5, 813-818. doi: 10.4236/jbise.2012.512A102.

References

[1] Schafer, D.F. and Sorrell, M.F. (1999) Hepatocellular carcinoma. Lancet, 353, 1253-1257. doi:10.1016/S0140-6736(98)09148-X
[2] T. Tsuzuki, et al. (1990) Hepatic resection for hepatocellular carcinoma. Surgery, 107, 511-520.
[3] Ahmed, M., Brace, C.L., Lee, F.T. and Goldberg, S.N. (2011) Principles of and advances in percutaneous abla- tion. Radiology, 258, 351-369. doi:10.1148/radiol.10081634
[4] Lencioni, R.A., et al. (2003) Small hepatocellular carcinoma in cirrhosis: Randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection. Radiology, 228, 235-240. doi:10.1148/radiol.2281020718
[5] Lencioni, R. (2010) Loco-regional treatment of hepato- cellular carcinoma. Hepatology, 52, 762-773. doi:10.1002/hep.23725
[6] Davalos, R., Mir, L. and Rubinsky, B. (2005) Tissue ab- lation with irreversible electroporation. Annals of Biome- dical Engineering, 33, 223-231.
[7] Weaver, J.C. (1993) Electroporation: A general phenomenon for manipulating cells and tissue. Journal of Cellular Biochemistry, 51, 426-435.
[8] Onik, G., Mikus, P. and Rubinsky, B. (2007) Irreversible electroporation: Implications for prostate ablation. Technology in Cancer Research and Treatment, 6, 295-300.
[9] Lee, E.W., Loh, C.T. and Kee, S.T. (2007) Imaging guided percutaneous irreversible electroporation: ultrasound and immunohistological correlation. Technology in Cancer Re- search and Treatment, 6, 287-293.
[10] Thomson, K.R. et al. (2011) Investigation of the safety of irreversible electroporation in humans. Journal of Vascu- lar and Interventional Radiology, 22, 611-621. doi:10.1016/j.jvir.2010.12.014
[11] Edd, J.F., Horowitz, L., Davalos, R.V., Mir, L.M. and Rubinsky, B. (2006) In vivo results of a new focal tissue ablation technique: Irreversible electroporation. IEEE Transactions on Biomedical Engineering, 53, 1409-1415. doi:10.1109/TBME.2006.873745
[12] Miklavcic, D., Semrov, D., Mekid, H. and Mir, L.M. (2000) A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochimica et Biophysica Acta, 1523, 73-83. doi:10.1016/S0304-4165(00)00101-X
[13] B. Al-Sakere, et al. (2007) Tumor ablation with irrever- sible electroporation. PLoS One, 2, e1135. doi:10.1371/journal.pone.0001135
[14] Neal, R.E., et al. (2011) Successful treatment of a large soft tissue sarcoma with irreversible electroporation. Jour- nal of Clinical Oncology, 29, e372-e377. doi:10.1200/JCO.2010.33.0902
[15] Neal, R. E., et al. (2010) Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode. Breast Cancer Research and Treatment, 123, 295-301. Aug. doi:10.1007/s10549-010-0803-5
[16] Garcia, P.A., et al. (2011) Non-thermal irreversible electroporation (N-TIRE) and adjuvant fractionated radiotherapeutic multimodal therapy for intracranial malignant glioma in a canine patient. Technology in Cancer Research and Treatment, 10, 73-83.
[17] Rubinsky, B., Onik, G. and Mikus, P. (2007) Irreversible electroporation: A new ablation modality: Clinical implications. Technology in Cancer Research and Treatment, 6, 37-48.
[18] Appelbaum, L., Ben-David, E., Sosna, J., Nissenbaum, Y. and Goldberg, S.N. (2012) US findings after irreversible electroporation ablation: Radiologic-pathologic correlation. Radiology, 262, 117-125. doi:10.1148/radiol.11110475
[19] Kim, Y.S., et al. (2011) Coagulation necrosis induced by radiofrequency ablation in the liver: Histopathologic and radiologic review of usual to extremely rare changes. Radiographics, 31, 377-390.doi:10.1148/rg.312105056
[20] Kim, S.K., et al. (2003) Hepatocellular carcinoma treated with radiofrequency ablation: Spectrum of imaging findings. Radiographics, 23, 107-121. doi:10.1148/rg.231025055

  
comments powered by Disqus
  • ADVERTISEMENT

Copyright © 2017 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.