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Studies on Processing and Characterization of Hydroxyapatite Biomaterials from Different Bio Wastes

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DOI: 10.4236/jmmce.2012.111005    5,658 Downloads   9,096 Views   Citations

ABSTRACT

Development of suitable materials that acts as an interface between the implant and tissues in body system structurally, mechanically and bio functionally is important for the success of tissue engineering. This motivated materials scientists and biologists to find out suitable bioactive materials for the aforementioned purpose. There has been growing interest in developing bioactive synthetic ceramics that could closely mimic natural apatite characteristics. Hydroxyapatite (HAp) has been widely used as a biocompatible ceramic but mainly for contact with bone tissue, due to its resemblance to mineral bone. This study presents the synthesis and characterization of HAp materials from different sources like bovine bone and fish scales and their application in tissue engineering. The phase purity and crystallinity of different calcined HAp powder was determined by XRD and FTIR analysis. The Thermo Gravimetric and Differential Thermal Analysis were carried out to show the thermal stability of the HAp powder. The morphology of the powder was observed under Scanning Electron Microscopy (SEM). Cytotoxicity evaluation of the developed powder was carried out in RAW macrophage like cell line media for an incubation period of 72 hours. These results proved the biocompatibility of HAp powders obtained from different biosources for tissue engineering applications.

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S. Mondal, B. Mondal, A. Dey and S. Mukhopadhyay, "Studies on Processing and Characterization of Hydroxyapatite Biomaterials from Different Bio Wastes," Journal of Minerals and Materials Characterization and Engineering, Vol. 11 No. 1, 2012, pp. 55-67. doi: 10.4236/jmmce.2012.111005.

References

[1] Mobasherpour, I., Heshajin, M. S., Kazemzadeh, A., M. Zakeri, M., 2007, ‘‘Synthesis of Nanocrystalline Hydroxyapatite by using Precipitation Method,’’ J. Alloys Compd., Vol. 430, pp. 330-333.
[2] Parthiban, S.P., Elayaraja, K., Girija, E. K., Yokogawa, Y., Kesavamoorthy, R., Palanichamy, M., Asokan, K., and Narayana Kalkura, S., 2009, “Preparation of thermally stable nanocrystalline hydroxyapatite by hydrothermal method.” J. Mater. Sc: Mater. Med., Vol. 20, pp. 77-83.
[3] Kim, W., Zhang, Q., and F. Saito., 2000, “Mechanochemical synthesis of hydroxyapatite from Ca(OH)2-P2O5 and CaO-Ca(OH) 2-P2O5 mixtures.” J. Mater. Sci., Vol. 35, pp. 5401-5405.
[4] Balamurugan, A., Kannan, S., and Rajeswari S., 2002, “Bioactive sol-gel hydroxyapatite surface for biomedical applications-in vitro study.” Trends. Biomater. Artif. Organs, Vol. 16, pp. 18-20.
[5] Tadic D., and. Epple, M., 2003, “Mechanically stable implants of synthetic bone mineral by cold isostatic pressing.”, Biomaterials, Vol. 24, pp. 4565-4571.
[6] Mondal, S., Mahata, S., Kundu, S., and Mondal, B., 2010, “Processing of natural resourced hydroxyapatite ceramics from fish scale.” Adv. Appl.Ceram.: Struct. Funct. Bioceram., Vol. 109, pp. 234-239.
[7] Sastry T.P., Sankar S., Mohan R., Rani S., Sundaraseelan T., 2008, “Preparation and partial characterization of collagen sheet from fish (Lates calcarifer) scales” International Journal of Biological Macromolecules, Vol. 42, pp. 6-9.
[8] Kalita, S.J., Bhardwaj, A., Bhatt, H.A., 2007, “Nanocrystalline calcium phosphate ceramics in biomedical engineering.” Materials Science and Engineering: C, Vol. 27 Issue 3, pp. 441-449.
[9] Liao, C. J., Lin, F. H., Chen, K. S., and J. S. Sun., J.S., 1999, “Thermal decomposition and reconstitution of hydroxyapatite in air atmosphere.” Biomaterials, Vol. 20, pp. 1807–1813.
[10] Roy, M., Krishna, B V., Bandyopadhya, A., Bose, S., 2011, “Compositionally graded hydroxyapatite/tricalcium phosphate coating on Ti by laser and induction plasma.” Acta Biomaterialia, Vol. 7, pp. 866-873.
[11] Stok, J. V. der, Lieshout, E. M. M. V., Massoudi, Y. E., Gerdine H. Van Kralingen, G. H. V., and Patka, P., 2011, “Bone substitutes in the Netherlands – A systematic literature review” Acta Biomaterialia., Vol. 7 , pp. 739-750.
[12] Mortier, A., Lemaitre, J., and Rouxhet, P.G., 1989, “Temperature programmed characterization of synthetic calcium deficient hydroxyapatite.” Thermochim. Acta,, Vol. 143, pp. 265-282.
[13] Ozawa, M., Suzuki, S., 2002 “Microstructural Development of Natural Hydroxyapatite Originated from Fish-Bone Waste through Heat Treatment.” J. Am. Ceram. Soc., Vol. 85, pp. 1315-1317.
[14] Rocha, J. H. G., Lemos, A.F., Kannan, S., Agathopoulos, S., Ferreira, J. M. F., 2005, “Hydroxyapatite scaffolds hydrothermally grown from aragonitic cuttlefish bones”, Journals of Materials Chemistry, Vol. 15, pp. 5007-5011.
[15] Varma, H.K., and Babu, S., 2005. “Synthesis of Calcium Phosphate Bioceramics by Citrate Gel Pyrolysis Method.” Ceram. Int., Vol. 31, pp. 109-114.

  
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