[1]
|
Cereghino, J.L. and Cregg, J.M. (2000) Heterologous protein expression in the methylotrophic yeast Pichia pastoris. FEMS Microbiology Reviews, 24, 45-66.
doi:10.1111/j.1574-6976.2000.tb00532.x
|
[2]
|
Hohenblum, H., Gasser, B., Maurer, M., Borth, N. and Mattanovich, D. (2004) Effects of gene dosage, promoters, and substrates on unfolded protein stress of recombinant Pichia pastoris. Biotechnology and Bioengineering, 85, 367-375. doi:10.1002/bit.10904
|
[3]
|
Resina, D., Cos, O., Ferrer, P. and Valero, F. (2005) Developing high cell density fed-batch cultivation strategies for heterologous protein production in Pichia pastoris using the nitrogen source-regulated FLD1 promoter. Biotechnology and Bioengineering, 91, 760-767.
doi:10.1002/bit.20545
|
[4]
|
McGrew, J.T., Leiske, D., Dell, B., Klinke, R., Krasts, D., Wee, S.F., Abbott, N., Armitage, R. and Harrington, K. (1997) Expression of trimeric CD40 ligand in Pichia pastoris: Use of a rapid method to detect high-level expressing transformants. Gene, 187, 193-200.
doi:10.1016/S0378-1119(96)00747-0
|
[5]
|
Paifer, E., Margolles, E., Cremata, J., Montesino, R., Herrera, L. and Delgado, J.M. (1994) Efficient expression and secretion of recombinant alpha-amylase in Pichia pastoris using 2 different signal sequences. Yeast, 10, 1415-1419.
doi:10.1002/yea.320101104
|
[6]
|
Zhao, H.L., He, Q., Xue, C., Sun, B., Yao, X.Q. and Liu, Z.M. (2009) Secretory expression of glycosylated and aglycosylated mutein of onconase from Pichia pastoris using different secretion signals and their purification and characterization. FEMS Yeast Research, 9, 591-599.
doi:10.1111/j.1567-1364.2009.00498.x
|
[7]
|
Bao, W.G. and Fukuhara, H. (2001) Secretion of human proteins from yeast: Stimulation by duplication of polyubiq- uitin and protein disulfide isomerase genes in Kluyvero-myces lactis. Gene, 272, 103-110.
doi:10.1016/S0378-1119(01)00564-9
|
[8]
|
Mukaiyama, H., Tohda, H. and Takegawa, K. (2010) Overexpression of protein disulfide isomerases enhances secretion of recombinant human transferrin in Schizosac-charomyces pombe. Applied Microbiology and Biotechnology, 86, 1135-1143. doi:10.1007/s00253-009-2393-x
|
[9]
|
Marx, H., Sauer, M., Resina, D., Vai, M., Porro, D., Valero, F., Ferrer, P. and Mattanovich, D. (2006) Cloning, disruption and protein secretory phenotype of the GAS1 homo-logue of Pichia pastoris. FEMS Microbiology Letters, 264, 40-47. doi:10.1111/j.1574-6968.2006.00427.x
|
[10]
|
Cos, O., Ramon, R., Montesinos, J. L. and Valero, F. (2006) Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris under different promoters: A review. Microbial Cell Factories, 5, 17.
doi:10.1186/1475-2859-5-17
|
[11]
|
Jahic, M., Veide, A., Charoenrat, T., Teeri, T. and Enfors, S.O. (2006) Process technology for production and recovery of heterologous proteins with Pichia pastoris, Bio- technology Progress, 22, 1465-1473.
|
[12]
|
Jahic, M., Gustavsson, M., Jansen, A.K., Martinelle, M. and Enfors, S.O. (2003) Analysis and control of proteolysis of a fusion protein in Pichia pastoris fed-batch processes. Journal of Biotechnology, 102, 45-53.
doi:10.1016/S0168-1656(03)00003-8
|
[13]
|
Zhang, Y.W., Liu, R.J. and Wu, X.Y. (2007) The proteolytic systems and heterologous proteins degradation in the methylotro-phic yeast Pichia pastoris. Annals of Microbiology, 57, 553-560. doi:10.1007/BF03175354
|
[14]
|
Huang, D. and Shusta, E.V. (2006) A yeast platform for the production of single-chain antibody-green fluorescent protein fusions. Applied Environmental Microbiology, 72, 7748-7759. doi:10.1128/AEM.01403-06
|
[15]
|
Kimata, Y., Kimata, Y.L., Shimizu, Y., Abe, H., Farcasanu, R.C., Takeuchi, M., Rose, M.D. and Kohno, K. (2003) Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins. Molecular Biology of the Cell, 14, 2559-2569.
doi:10.1091/mbc.E02-11-0708
|
[16]
|
Schroder, M. and Kaufman, R.J. (2005) The mammalian unfolded protein response. Annual Review of Biochemistry, 74, 739-789.
doi:10.1146/annurev.biochem.73.011303.074134
|
[17]
|
Travers, K.J., Patil, C.K., Wodicka, L., Lockhart, D.J., Weissman, J.S. and Walter, P. (2000) Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degra- dation. Cell, 101, 249-258.
doi:10.1016/S0092-8674(00)80835-1
|
[18]
|
Gemmill, T.R. and Trimble, R.B. (1999) Overview of N- and O-linked oligosaccharide structures found in various yeast species. BBA-General Subjects, 1426, 227-237.
doi:10.1016/S0304-4165(98)00126-3
|
[19]
|
Liu, J.N., Qian, Y.J. and Holgersson, J. (1997) Removal of xenore-active human anti-pig antibodies by absorption on re-combinant mucin-containing glycoproteins carrying the Gal alpha 1,3Gal epitope. Transplantation, 63, 1673- 1682. doi:10.1097/00007890-199706150-00023
|
[20]
|
Gustavsson, M., Lehtio, J., Denman, S., Teeri, T.T., Hult, K. and Martinelle, M. (2001) Stable linker peptides for a cellu-lose-binding domain-lipase fusion protein expressed in Pichia pastoris. Protein Engineering, 14, 711-715.
doi:10.1093/protein/14.9.711
|
[21]
|
Liu, J.N., Gustafsson, A., Breimer, M.E., Kussak, A. and Holgersson, J. (2005) Anti-pig antibody adsorption effi- cacy of alpha-Gal car-rying recombinant P-selectin glyco- protein ligand-1/immunoglobulin chimeras increases with core 2 beta 1,6-N-acetylglucosaminyltransferase expres- sion. Glycobiology, 15, 571-583.
doi:10.1093/glycob/cwi037
|
[22]
|
Guerfal, M., Ryckaert, S., Jacobs, P.P., Ameloot, P., Van Craenenbroeck, K., Derycke, R. and Callewaert, N. (2010) The HAC1 gene from Pichia pastoris: Characterization and effect of its over expression on the production of secreted, surface displayed and membrane proteins. Microbial Cell Factories, 9, 49. doi:10.1186/1475-2859-9-49
|
[23]
|
Livak, K.J. and Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods, 25, 402- 408. doi:10.1006/meth.2001.1262
|
[24]
|
Gustafsson, A. and Holgersson, J. (2006) A new generation of carbohy-drate-based therapeutics: Recombinant mucin-type fusion proteins as versatile inhibitors of protein-carbohydrate interactions. Expert Opinion on Drug Discovery, 1, 161-178. doi:10.1517/17460441.1.2.161
|
[25]
|
Gustafsson, A., Sjoblom, M., Strindelius, L., Johansson, T., Flecken-stein, T., Chatzissavidou, N., Lindberg, L., Angstrom, J., Rova, U. and Holgersson, J. (2011) Pichia pastoris-produced mucintype fusion proteins with multi-valent O-glycan substitution as targeting molecules for mannose-specific receptors of the immune system. Glycobiology, 21, 1071-1086. doi:10.1093/glycob/cwr046
|
[26]
|
Tsien, R.Y. (1998) The green fluorescent protein. Annual Review of Biochemistry, 67, 509-544.
doi:10.1146/annurev.biochem.67.1.509
|
[27]
|
Huang, D. and Shusta, E.V. (2006) A yeast platform for the production of single-chain antibody-green fluorescent protein fusions. Applied and Environmental Microbiology, 72, 7748-7759. doi:10.1128/AEM.01403-06
|
[28]
|
Van den Steen, P., Rudd, P.M., Proost, P., Martens, E., Paemen, L., Kuster, B., van Damme, J., Dwek, R.A. and Opdenakker, G. (1998) Oligosaccharides of recombinant mouse gelatinase B variants. BBA-General Subjects, 1425, 587-598. doi:10.1016/S0304-4165(98)00113-5
|
[29]
|
Ng, D.T.W., Spear, E.D. and Walter, P. (2000) The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control. Journal of Cell Biology, 150, 77-88. doi:10.1083/jcb.150.1.77
|
[30]
|
Bernales, S., Papa, F.R. and Walter, P. (2006) Intracellular signaling by the unfolded protein response. Annual Review of Cell and Developmental Biology, 22, 487-508.
doi:10.1146/annurev.cellbio.21.122303.120200
|
[31]
|
Bevis, B.J., Hammond, A.T., Reinke, C.A. and Glick, B. S. (2002) De novo formation of transitional ER sites and Golgi structures in Pichia pastoris. Nature Cell Biology, 4, 750-756. doi:10.1038/ncb852
|
[32]
|
Curvers, S., Linnemann, J., Klauser, T., Wandrey, C. and Takors, R. (2001) Recombinant protein production with Pichia pastoris in continous fermentation—Kinetic analysis of growth and product formation. Chemie Ingenieur Technik, 73, 1615-1621.
doi:10.1002/1522-2640(200112)73:12<1615::AID-CITE1615>3.3.CO;2-Y
|