A Double-Blind, Randomized, Placebo-Controlled Nutritional Study Using an Insoluble Yeast Beta-Glucan to Improve the Immune Defense System

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DOI: 10.4236/fns.2012.36100    4,293 Downloads   8,746 Views   Citations

ABSTRACT

Purpose: In a placebo-controlled, double-blind, randomized clinical trial, the effect of an insoluble yeast beta-glucan preparation on the incidences of common colds and its effect on common cold symptoms were compared to placebo. Methods: 100 healthy participants with recurring infections were randomly assigned to receive either placebo or yeast beta-glucan (Yestimun?; n = 50 each group) over a period of 26 weeks. The subjects had to document each common cold episode in a diary, and rate 6 predefined infections symptoms on a 3-point rating scale during an infection period, resulting in an infection score. The common cold episodes were confirmed by the investigators. Results: A total of 171 common cold episodes were documented. Of these, 76 were experienced by 38 subjects in the beta-glucan group and 96 were experienced by 48 subjects in the placebo group (p = 0.406). The beta-glucan group had significantly more subjects without incidences of common cold than the placebo group (15.6% vs 2.0%; p = 0.019). During the most intense infection season (first 13 weeks of the study), the beta-glucan group had significantly less infections compared to placebo (p = 0.02). Beta-glucan significantly reduced the typical cold symptoms (“sore throat and/or difficulty swallowing”, “hoarseness and/or cough” and “runny nose”) as opposed to placebo. Conclusion: The present study demonstrates a prophylactic effect of yeast beta-glucan on the occurrence of common colds as opposed to placebo. In addition, when these episodes occurred, they were from the beginning less pronounced and subsided faster.

Cite this paper

H. Graubaum, R. Busch, H. Stier and J. Gruenwald, "A Double-Blind, Randomized, Placebo-Controlled Nutritional Study Using an Insoluble Yeast Beta-Glucan to Improve the Immune Defense System," Food and Nutrition Sciences, Vol. 3 No. 6, 2012, pp. 738-746. doi: 10.4236/fns.2012.36100.

References

[1] B. Blattberg, “Increase in Bactericidal Activity as A Result of Injection of Zymosan,” Proceedings of the Society for Experimental Biology and Medicine, Vol. 92, No. 4, 1956, pp. 745-748.
[2] G. C. Chan, W. K. Chan and D. M. Sze, “The Effects of Beta-Glucan on Human Immune and Cancer Cells,” Journal of Hematology & Oncology, Vol. 2, No. 2009, 2009, p. 25.
[3] D. B. Zekovic, S. Kwiatkowski, M. M. Vrvic, D. Jakovljevic and C. A. Moran, “Natural and Modified (1 3)-Beta-D-Glucans in Health Promotion and Disease Alleviation,” Critical Reviews in Biotechnology, Vol. 25, No. 4, 2005, pp. 205-230. doi:10.1080/07388550500376166
[4] L. G. Fleischer, G. Gerber, G. Gremmels, H.-D. Lippert and G. Westphal, “Experimentelle Modelluntersuchungen zum Einsatz von (1,3),(1,6)-Beta-D-Glucan aus Saccharomyces Cerevisiae Fibona Health Products GmbH,” 2001.
[5] J. Li, J. Xing, D. Li, X. Wang, L. Zhao, S. Lv and D. Huang, “Effects of Beta-Glucan Extracted from Saccharomyces Cerevisiae on Humoral and Cellular Immunity in Weaned Piglets,” Archives of Animal Nutrition, Vol. 59, No. 5, 2005, pp. 303-312. doi:10.1080/17450390500247832
[6] D. Akramiene, A. Kondrotas, J. Didziapetriene and E. Kevelaitis, “Effects of Beta-Glucans on the Immune System,” Medicina, Vol. 43, No. 8, 2007, pp. 597-606.
[7] J. A. Bohn and J. N. BeMiller, “(1→3)-β-D-Glucans as Biological Response Modifiers: A Review of Structure-Functional Activity Relationships,” Carbohydrate Polymers, Vol. 28, 1995, pp. 3-14. doi:10.1016/0144-8617(95)00076-3
[8] T. Kojima, K. Tabata, W. Itoh and T. Yanaki, “Molecular Weight Dependence of the Antitumor Activity of Schizophyllan,” Agricultural Biology and Chemistry, Vol. 50, No. 1, 1986, pp. 231-232. doi:10.1271/bbb1961.50.231
[9] E. Sonck, B. Devriendt, B. Goddeeris and E. Cox, “Varying Effects of Different Beta-Glucans on the Maturation of Porcine Monocyte-Derived Dendritic Cells,” Clinical and Vaccine Immunology, Vol. 18, No. 9, 2011, pp. 14411446. doi:10.1128/CVI.00080-11
[10] D. C. Nieman, D. A. Henson, M. McMahon, J. L. Wrieden, J. M. Davis, E. A. Murphy, S. J. Gross, L. S. McAnulty and C. L. Dumke, “Beta-glucan, Immune Function, and Upper Respiratory Tract Infections in Athletes,” Medicine and Science in Sports and Exercise, Vol. 40, No. 8, 2008, pp. 1463-1471. doi:10.1249/MSS.0b013e31817057c2
[11] J. Malaczewska, R. Wójcik, L. Jung and A. K. Siwicki, “Effect of Biolex β-HP on Selected Parameters of Specific and Non-Specific Humoral and Cellular Immunity in Rats,” Bulletin of the Veterinary Institute in Pulawy, Vol. 54, No. 1, 2010, pp. 75-80.
[12] R. Wojcik, “Effect of Biolex Beta-HP on Phagocytic Activity and Oxidative Metabolism of Peripheral Blood Granulocytes and Monocytes in Rats Intoxicated by Cyclophosphamide,” Polish Journal of Veterinary Sciences, Vol. 13, No. 1, 2010, pp. 181-188.
[13] R. Wójcik, E. Janowska, J. Malaczewska and A. K. Siwicki, “Effect of β-1,3/1,6-D-glucan on the Phagocytic Activity and Oxidative Metabolism of Peripheral Blood Granulocytes and Monocytes in Rats,” Bulletin of the Veterinary Institute in Pulawy, Vol. 53, No. 2, 2009, pp. 241-246.
[14] R. Eccles, “Understanding the Symptoms of the Common Cold and Influenza,” Lancet Infectious Diseases, Vol. 5, No. 11, 2005, pp. 718-725. doi:10.1016/S1473-3099(05)70270-X
[15] S. Talbott and J. Talbott, “Effect of BETA 1,3/1,6 GLUCAN on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athlets,” Journal of Sports Science and Medicine, Vol. 8, 2009, pp. 509-515.
[16] D. C. Nieman, “Risk of Upper Respiratory Tract Infection in Athletes: An Epidemiologic and Immunologic Perspective,” Journal of Athletic Training, Vol. 32, No. 4, 1997, pp. 344-349.
[17] N. P. Walsh, M. Gleeson, R. J. Shephard, J. A. Woods, N. C. Bishop, M. Fleshner, C. Green, B. K. Pedersen, L. Hoffman-Goetz, C. J. Rogers, H. Northoff, A. Abbasi and P. Simon, “Position Statement. Part One: Immune Function and Exercise,” Exercise Immunology Review, Vol. 17, 2011, pp. 6-63.
[18] K. Bergendiova, E. Tibenska and J. Majtan, “Pleuran (Beta-Glucan from Pleurotus ostreatus) Supplementation, Cellular Immune Response and Respiratory Tract Infections in Athletes,” European Journal of Applied Physiology, Vol. 111, No. 9, 2011, pp. 2033-2040. doi:10.1007/s00421-011-1837-z
[19] S. Feldman, H. I. Schwartz, D. S. Kalman, A. Mayers, H. M. Kohrman, R. Clemens and D. Krieger, “Randomized Phase II Clinical Trials of Wellmune WGP for Immune Support during Cold and Flu Season,” Journal of Applied Research, Vol. 9, No. 1-2, 2009, pp. 30-42.
[20] P. J. Rice, E. L. Adams, T. Ozment-Skelton, A. J. Gonzalez, M. P. Goldman, B. E. Lockhart, L. A. Barker, K. F. Breuel, W. K. Deponti, J. H. Kalbfleisch, H. E. Ensley, G. D. Brown, S. Gordon and D. L. Williams, “Oral Delivery and Gastrointestinal Absorption of Soluble Glucans Stimulate Increased Resistance to Infectious Challenge,” Journal of Pharmacology and Experimental Therapeutics, Vol. 314, No. 3, 2005, pp. 1079-1086. doi:10.1124/jpet.105.085415
[21] H. S. Goodridge, C. N. Reyes, C. A. Becker, T. R. Katsumoto, J. Ma, A. J. Wolf, N. Bose, A. S. Chan, A. S. Magee, M. E. Danielson, A. Weiss, J. P. Vasilakos and D. M. Underhill, “Activation of the Innate Immune Receptor Dectin-1 upon Formation of a ‘Phagocytic Synapse’,” Nature, Vol. 472, No. 7344, 2011, pp. 471-475. doi:10.1038/nature10071
[22] R. Schoop, P. Klein, A. Suter and S. L. Johnston, “Echinacea in the Prevention of Induced Rhinovirus Colds: A Meta-Analysis,” Clinical Therapeutics, Vol. 28, No. 2, 2006, pp. 174-183. doi:10.1016/j.clinthera.2006.02.001
[23] S. A. Shah, S. Sander, C. M. White, M. Rinaldi and C. I. Coleman, “Evaluation of Echinacea for the Prevention and Treatment of the Common Cold: A Meta-Analysis,” Lancet Infectious Diseases, Vol. 7, No. 7, 2007, pp. 473480. doi:10.1016/S1473-3099(07)70160-3
[24] D. S. Senchina, N. B. Shah, D. M. Doty, C. R. Sanderson and J. E. Hallam, “Herbal Supplements and Athlete Immune Function—What’s Proven, Disproven, and Unproven?” Exercise Immunology Review, Vol. 15, 2009, pp. 66-106.
[25] D. Sch?neberger, “Immunstimulierende Wirkung von Echinacin Madaus Liquidum auf Verlauf und Schweregrad von Erk?ltungskrankheiten,” Forum Immunologie, Vol. 8, 1996, pp. 2-11.
[26] W. Grimm and H. Müller, “A Randomized Controlled Trial of the Effect of Fluid Extract of Echinacea Purpureaz on the Indicence and Severity of Colds and Respiratory Infections,” American Journal of Medicine, Vol. 109, 1999, pp. 138-143. doi:10.1016/S0002-9343(98)00406-9
[27] R. M. Douglas, H. Hemila, E. Chalker and B. Treacy, “Vitamin C for Preventing and Treating the Common Cold,” Cochrane Database of Systematic Reviews, Vol. 3, 2007, Article ID: CD000980.
[28] M. Singh and R. R. Das, “Zinc for the Common Cold,” Cochrane Database of Systematic Reviews, Vol. 2, 2011, Article ID: CD001364. doi:10.1002/14651858.CD001364.pub3

  
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