JBBS> Vol.2 No.2, May 2012

Origins and Mechanisms in the Development of Major Mental Disorders: A Clinical Approach

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ABSTRACT

This paper considers the following collective significance of the shared, clinical characteristics of the major mental disorders (MMDs), their co-morbidities, overlaps and pharmacological responses with the following conclusions: 1) These disorders have a common, initial, neurodevelopmental origin. 2) They can occur probabilistically on susceptible individuals, on account of pre-existing, extreme, temperamental variances-signifying underlying structural variance. 3) Each of these syndromes can be considered the expression of disturbances in the overall, common, operating mode of brain function which normally ensures the synchrony, coordination, elegance and subtlety in the expression of all the brain’s higher faculties. 4) Lastly, this function is a complex, emergent phenomenon based on the individual’s temperamental/structural underlying makeup, switching intermittently from a normal phase to a pathologically, ordered one-the latter phase expressing itself with symptoms made up of expressing either/or, antithetical substitutes for each of the MMDs-similar to the fluctuations found in patient’s with Parkinson’s disease.

Cite this paper

N. Pediaditakis, "Origins and Mechanisms in the Development of Major Mental Disorders: A Clinical Approach," Journal of Behavioral and Brain Science, Vol. 2 No. 2, 2012, pp. 269-275. doi: 10.4236/jbbs.2012.2230.

References

[1] S. Chess and A. T. Chess, “Temperament: Theory and Practice,” Brunner/Mazel, New York, 1996.
[2] N. Pediaditakis, “Borderline Phenomenon Revisited: A Synthesis,” Psychiatric Times, 2002, pp. 37-41.
[3] H. J. Eysenck, “The Definition and Measurement of Psychotism,” Personality and Individual Differences, Vol. 13, No. 7, 1992, pp. 757-785. doi:10.1016/0191-8869(92)90050-Y
[4] C. G. Jung, “Psychological Type,” Princeton University Press, Harcourt & Brace, Princeton, 1971.
[5] C. R. Cloninger, D. M., Svrakic and T. R. Przybeck, “A Psychobiological Model of Temperament and Character,” Archieves of General Psychiatry, Vol. 50, No. 12, 1993, 975-990. doi:10.1001/archpsyc.1993.01820240059008
[6] K. David and M. Bates, “Please Understand Me: Character & Temperament Types,” Prometheus Nemesis Book Co., Carlsbad, 1998.
[7] N. Pediaditakis, “Shared Characteristics in the Clinical Expression and Pharmacological Responses of Mental Disorders and Their Possible Collective Significance,” Medical Hypotheses, Vol. 50, No. 4, 1998, pp. 347-352. doi:10.1016/S0306-9877(98)90124-4
[8] N. C. Andreasen, “Creativity and Mental Illness Prevalence Rates in Whites and Their First Degree Relatives,” American Journal of Psychiatry, Vol. 144, No. 9, 1987, pp. 1288-1292.
[9] K. R. Jamison, “Mood Disorders and Patterns of Creativity in British Writers and Artists,” Psychiatry, Vol. 32, 1989, pp. 125-134.
[10] K. R. Jamison, “Touched by Fire: Manic-Depressive Illness and the Artistic Temperament,” The Free Press, New York, 1993.
[11] J. E. Steinmetz, “The Study of Temperament: Changes, Continuities, and Challenges,” Lawrence Erlbaum Associates, Hillsdale, 1986.
[12] S. Arieti, “Premorbid Personality in Schizophrenia,” American Handbook of Psychiatry, NY Basic Books, New York, 1959, p. 472.
[13] A. R. Yung and P. D. McGorry, “The Prodromal Phase of First Episode Psychosis: Past and Current Conceptualiztions,” Schizophrenia Bulletin, Vol. 22, No.2, 1996, pp. 353-370. doi:10.1093/schbul/22.2.353
[14] H. I. Kaplan, B. J. Sadock and J. A. Grebb, “Positive and Negative Symptoms of Schizophrenia,” Synopsis of Psychiatry, 7th Edition, Williams & Wilkins, New York, 1994.
[15] D. R. Hirshfeld-Becker, “Behavioral Inhibition and Disinhibition as Hypothesized Precursors to Psychopathology: Implications for Pediatric Bipolar Disorder,” Biological Psychiatry, Vol. 53, No. 11, 2003, pp. 985-999. doi:10.1016/S0006-3223(03)00316-0
[16] A. M. Benis, and J. H. Rand, “A Model of Human Personality Based on Mendelian Genetics,” Proceeding of American Association for the Advancement of Science, Vol. 86, No. 5, 1986, p. 124.
[17] A. Sz?ke, F. Schürhoff, F. Bellivier, F. Rouillon and M. Leboyer, “Temperament in Schizophrenia: A Study of the Tridimensional Personality Questionnaire (TPQ),” European Psychiatry, Vol. 17, No. 7, 2002, pp. 379-383. doi:10.1016/S0924-9338(02)00700-9
[18] American Psychiatric Association, “Diagnostic and Statistical Manual of Mental Disorder,” 4th Edition, Washington DC, 1994.
[19] V. Arolt and H. Dilling, “Confounding Diagnostic Systems: A Major Risk in the Use of Criteria-Based Manuals,” Psychopathology, Vol. 27, No. 1-2, 1994, pp. 58-63. doi:10.1159/000284849
[20] J. A. Neal and R. J. Edelmann, “The Etiology of Social Phobia toward a Developmental Profile,” Clinical Psychological Review, Vol. 23, No. 6, 2003, pp. 761-786.
[21] N. Pediaditakis, “Deterministic Nonlinear Chaos in Brain Function and Borderline Psychopathological Phenomena,” Medical Hypotheses, Vol. 39, No. 1, 1992, pp. 67-72. doi:10.1016/0306-9877(92)90143-Z
[22] H. M. Maru, D. M. Kathuku and D. M. Ndetei, “Psychiatric Morbidity Among Children and Young Persons Appearing in the Nairobi Juvenile Court, Kenya,” East African Medical Journal, Vol. 80, No. 6, 2003, pp. 226-232.
[23] F. G. Moeller, E. S. Barratt, D. M. Dougherty, J. M. Schmitz and A. C. Swann, “Psychiatric Aspects of Impulsivity,” American Journal of Psychiatry, Vol. 158, No. 11, 2001, pp. 1783-1793. doi:10.1176/appi.ajp.158.11.1783
[24] C. Henry, “Affective Instability and Impulsivity in Borderline Personality and Bipolar II Disorders, Similarities and Differences,” Journal of Psychiatr Research, Vol. 35, Vol. 6, 2001, pp. 307-312.
[25] D. N. Klein and J. E. Schwartz, “The Relation between Depressive Symptoms and Borderline Personality Disorder Features over Time in Dysthymic Disorder,” Journal of Personal Disorder, Vol. 16, No. 6, 2002, pp. 523-535. doi:10.1521/pedi.16.6.523.22143
[26] G. Claridge, “Creativity and Madness: Clues from Modern Psychiatric Diagnosis,” Genius and the Mind, Oxford University Press, Oxford, 1980.
[27] K.-H. Reger and H. Dilling, “History of Psychiatry in Lubeck: The Nineteenth Century,” History of Psychiatry, Vol. 5, No. 18, 1994, pp. 157-174. doi:10.1177/0957154X9400501801
[28] M. A. Taylor, S. A. Berenbaum, V. C. Jampala and C. R. Cloninger, “Are Schizophrenia and Affective Disorder Related? Preliminary Data from a Family Study,” American Journal of Psychiatry, Vol. 150, Vol. 2, 1993, pp. 278-285.
[29] D. M. Fergusson, L. J. Horwood and M. T. Lynskey, “Prevalence and Comorbidity of DSM-III-R Diagnoses in a Birth Cohort of 15 Year Olds,” Journal of the American Academy of Child, Vol. 32, Vol. 6, 1993, pp. 1127-1134.
[30] A. E. Doyle and S. V. Faraone, “Familial Links between Attention Deficit Hyperactivity Disorder, Conduct Disorder and Bipolar Disorder,” Current Psychiatry Reports, Vol. 4, 2002, pp. 146-152. doi:10.1007/s11920-002-0049-y
[31] B. F. Grant, “Prevalence, Correlates, and Disability of Personality Disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions,” Journal of Clinical Psychiatry, Vol. 65, 2004, pp. 948-958. doi:10.4088/JCP.v65n0711
[32] N. Pediaditakis, “The Occurrence of Schizophrenia in Monozygotic Twins and Fractal, Dentritic Development,” Archives of General Psychiatry, Vol. 53, No. 1, 1996, p. 85. doi:10.1001/archpsyc.1996.01830010087014
[33] W. F. Baare, et al., “Volumes of Brain Structures in Twins Discordant for Schizophrenia,” Archives of General Psychiatry, Vol. 58, No. 1, 2001, pp. 33-40. doi:10.1001/archpsyc.58.1.33
[34] M. P. Freeman, S. A. Freeman and S. L. McElroy, “The Comorbidity of Bipolar and Anxiety Disorders: Prevalence, Psychobiology and Treatment Issues,” Journal of Affect Disorder, Vol. 68, No. 1, 2002, pp. 1-23. doi:10.1016/S0165-0327(00)00299-8
[35] R. McIntyre and M. Katzman, “The Role of Atypical Antipsychotics in Bipolar Depression and Anxiety Disorders,” Bipolar Disorder, Vol. 5, Suppl. s2, 2003, pp. 20-35.
[36] H. Akiskal, “Temperament: The Bridge between Biology and Affective Illness,” Annals of General Psychiatry, Vol. 2, Suppl. 1, 2003, p. 548.
[37] L. N. Yatham, “Efficacy of Atypical Antipsychotics in Mood Disorders,” Journal of Clinical Psychopharmacology, Vol. 23, No. 3, 2003, pp. 9-14. doi:10.1097/01.jcp.0000084036.22282.ea
[38] A. Breier, “Effects of Clozapine on Positive and Negative Symptoms in Outpatients with Schizophrenia,” American Journal of Psychiatry, Vol. 151, No. 1, 1994, pp. 20-26.
[39] R. F. Asarnow, “Schizophrenia and Schizophrenia-Spectrum Personality Disorders in the First-Degree Relatives of Children with Schizophrenia,” Archives General Psychiatry, Vol. 58, No. 6, 2001, pp. 581-588. doi:10.1001/archpsyc.58.6.581
[40] C. Wijeratne, G. S. Halliday and R. W. Lyndon, “The Present Status of Electroconvulsive Therapy: A Systematic Review,” Medical Journal of Australia, Vol. 171, No. 5, 1999, pp. 250-254.
[41] C. A. Skarda and W. J. Freeman, “How Brains Make Chaos in Order to Make Sense of the World,” Behavioral and Brain Sciences, Vol. 10, No. 2, 1987, pp. 161-195. doi:10.1017/S0140525X00047336
[42] C. King, “Fractal and Chaotic Dynamics in Nervous Systems,” Progress in Neurobiology, Vol. 36, No. 4, 1991, pp. 279-308. doi:10.1016/0301-0082(91)90003-J

  
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