Adrenocortical system activity in alloxan-resistant and alloxan-susceptible Wistar rats

Vera G. Selyatitskaya, Natalya A. Palchikova, Natalya V. Kuznetsova

Siberian Branch of Russian Academy Medical Sciences, Scientific Centre of Clinical and Experimental Medicine, Novosibirsk, Russia.

DOI: 10.4236/jdm.2012.22026                

Abstract

In the dynamics of the disease development, diuresis and glycosuria increase in alloxan-susceptible rats, while in alloxan-resistant rats the increase in the values of these indices is expressed to a lesser extent, and they begin to decrease by day 8 of the disease. In alloxan-susceptible rats, the mass index of adrenal gland is increased, and that of thymus is decreased and corticosterone concentration in blood, adrenal gland and urine as well as alanine and aspartate aminotransferase activities in liver are increased; in alloxan-resistant rats the values of these indices do not differ from those of rats of the control group.

Keywords

Experimental Diabetes; Alloxan-Resistant and Alloxan-Susceptible Rats; Adrenocortical System Activity; Corticosteroids Concentration in Urine

Conflicts of Interest

The authors declare no conflicts of interest.

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