Share This Article:

Peripheral T-Cell Lymphoma of Cervical Spine

Full-Text HTML XML Download Download as PDF (Size:882KB) PP. 96-99
DOI: 10.4236/ss.2012.32019    4,004 Downloads   6,282 Views  

ABSTRACT

Peripheral T-cell lymphoma is a rather uncommon non-Hodgkin’s lymphoma with the initial manifestation of spinal cord compression. Herein, we reported a 74-year-old woman with sustained neck pain radiating into the right shoulder and arm and weakness of the right upper extremity. A mass that had invaded the C5 and C6 vertebral bodies, causing a kyphotic curvature and compressing the spinal cord, was discovered with magnetic resonance imaging. The patient then underwent anterior corpectomy at C5 and C6, and reconstruction with a titanic rod and bone cement. The pathology confirmed a diagnosis of peripheral T-cell lymphoma after serial H & E and immunohistochemical staining. She recovered well from her profound neurological deficit. Both chemotherapy and radiotherapy were used postoperatively. Surgical intervention is indicated in these cases to decompress the cord, remove the majority of the tumor mass, stabilize the spine and obtain tissue for pathological diagnosis.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

F. Lian, W. Tsai and C. Hsieh, "Peripheral T-Cell Lymphoma of Cervical Spine," Surgical Science, Vol. 3 No. 2, 2012, pp. 96-99. doi: 10.4236/ss.2012.32019.

References

[1] B. Vanneuville, A. Janssens, M. Lemmerling, K. de Vlam, H. Mielants and E. M. Veys, “Non-Hodgkin’s Lymphoma Presenting with Spinal Involvement,” Annals of the Rheumatic Diseases, Vol. 59, No. 1, 2000, pp. 12-14. doi:10.1136/ard.59.1.12
[2] J. R. Perry, S. S. Deodhare, J. M. Bilbao, D. Murray and P. Muller, “The Significance of Spinal Cord Compression as the Initial Manifestation of Lymphoma,” Neurosurgery, Vol. 32, No. 2, 1993, pp. 157-162. doi:10.1227/00006123-199302000-00001
[3] C. E. Dearden and F. M. Foss, “Peripheral T-Cell Lymphomas: Diagnosis and Management,” Hematology/Oncology Clinics of North America, Vol. 17, No. 6, 2003, pp. 1351-1366. doi:10.1016/S0889-8588(03)00119-9
[4] A. Gallamini, C. Stelitano, R. Calvi, M. Bellei, D. Mattei and U. Vitolo, “Peripheral T-Cell Lymphoma Unspecified (PTCL-U): A New Prognostic Model from a Retrospective Multicentric Clinical Study,” Blood, Vol. 103, No. 7, 2004, pp. 2474-2479. doi:10.1182/blood-2003-09-3080
[5] H. J. Lee, J. G. Im, J. M. Goo, K. W. Kim, B. I. Choi and K. H. Chang, “Peripheral T-Cell Lymphoma: Spectrum of Imaging Findings with Clinical and Pathologic Features,” Radiographics, Vol. 23, No. 1, 2003, pp. 7-26. doi:10.1148/rg.231025018
[6] A. Lopez-Guillermo, J. Cid, A. Salar, A. Lopez, C. Montalban and J. M. Castrillo, “Peripheral T-Cell Lymphomas: Initial Features, Natural History, and Prognostic Factors in a Series of 174 Patients Diagnosed According to the R.E.A.L. Classification,” Annals of Oncology, Vol. 9, No. 8, 1998, pp. 849-855. doi:10.1023/A:1008418727472
[7] Z. Klezl, M. Krbec, E. Gregora and J. Stritesky, “Rare Presentation of Non-Hodgkin Lymphoma of the Thoracolumbar Spine in Pregnancy with 7 Years’ Survival,” Archives of Orthopaedic and Trauma Surgery, Vol. 122, No. 5, 2002, pp. 308-310.
[8] G. S. Pinkus, C. J. O’ara and J. W. Said, “Eripheral/Post- Thymic T-Cell Lymphomas: A Spectrum of Disease. Clinical, Pathogic, and Immunologic Features of 78 Cases,” Cancer, Vol. 65, No. 4, 1990, pp. 971-998. doi:10.1002/1097-0142(19900215)65:4<971::AID-CNCR2820650425>3.0.CO;2-B
[9] R. Epelbaum, N. Haim, M. Ben-Shahar, Y. Ben-Arie, M. Feinsod and Y. Cohen, “On-Hodgkin’ Lymphoma Presenting with Spinal Epidural Involvement,” Cancer, Vol. 58, No. 9, 1986, pp. 2120-2124. doi:10.1002/1097-0142(19861101)58:9<2120::AID-CNCR2820580926>3.0.CO;2-A
[10] C. C. Luo, “Spinal Cord Compression Secondary to Metastatic Non-Hodgkins Lymphoma: A Case Report,” Archives of Physical Medicine and Rehabilitation, Vol. 86, No. 2, 2005, pp. 332-334. doi:10.1016/j.apmr.2004.06.063
[11] J. W. Grant, D. Kaech and D. B. Jones, “Spinal Cord Compression as the First Presentation of Lymphoma—A Review of 15 Cases,” Histopathology, Vol. 10, No. 11, 1986, pp. 1191-1202. doi:10.1111/j.1365-2559.1986.tb02559.x
[12] E. T. Wong, C. S. Portlock, J. P. O’Brien and L. M. DeAngelis, “Chemosensitive Epidural Spinal Cord Disease in Non-Hodgkins Lymphoma,” Neurology, Vol. 46, No. 6, 1996, pp. 1543-1547.
[13] J. Correale, D. A. Monteverde, J. A. Bueri and E. G. Reich, “Peripheral Nervous System and Spinal Cord Involvement in Lymphoma,” Acta Neurologica Scandinavica, Vol. 83, No. 1, 1991, pp. 45-51. doi:10.1111/j.1600-0404.1991.tb03957.x
[14] C. Andreula and M. Murrone, “Metastatic Disease of the Spine,” European Radiology, Vol. 15, No. 3, 2005, pp. 627-632. doi:10.1007/s00330-004-2627-3
[15] Y. Huang, T. Y. Lin, Q. L. Wu, Z. L. Su, H. Q. Huang and Z. J. Xia, “Survival Outcomes of T-Cell Non-Hodgkin’s Lymphoma: A Report of 111 Cases,” Ai Zheng, Vol. 24, No. 4, 2005, pp. 470-474.
[16] S. M. Ansell, T. M. Habermann, P. J. Kurtin, T. E. Witzig, M. G. Chen and C. Y. Li, “Predictive Capacity of the International Prognostic Factor Index in Patients with Peripheral T-Cell Lymphoma,” Journal of Clinical Oncology, Vol. 15, No. 6, 1997, pp. 2296-2301.
[17] R. Viswanathan, N. K. Swamy, J. Vago and S. B. Dunsker, “Lymphoma of the Lumbar Nerve Root: Case Report,” Neurosurgery, Vol. 41, No. 2, 1997, pp. 479-481. doi:10.1097/00006123-199708000-00033

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.