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Comparative study between the effect of Momordica charantia (wild and hybrid variety) on hypoglycemic and hypolipidemic activity of alloxan induced type 2 diabetic long-evans rats

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DOI: 10.4236/jdm.2012.21022    4,514 Downloads   8,623 Views   Citations

ABSTRACT

This study was undertaken to evaluate the hypoglycemic and hypolipidemic effect of Momordica charantia (wild and hybrid variety) powder on alloxan induced type 2 diabetic male Long-Evans rats. Oral feeding of the M. charantia powder slightly decreased serum total cholesterol, triglyceride levels and LDL-cholesterol compared with wild, hybrid and standard drug. M. charantia wild variety showed more significant (p < 0.05, 0.01, 0.001) effect on blood glucose level when compared with hybrid variety and standard drug (glibenclamide, 5 mg/kg). At the same time rats’ serum insulin level markedly increased, wild variety showed more significant (p < 0.05, 0.01, 0.001) than glibenclamide control group and hybrid group. But M. charantia did not show any significant effect on HDL-cholesterol and liver glycogen. Thus, results of the study prove that the wild variety of M. charantia fruit have potent antidiabetic and antilipidemic property.

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Saha, S. , Haque, M. , Islam, D. , Rahman, M. , Islam, M. , Parvin, A. and Rahman, S. (2012) Comparative study between the effect of Momordica charantia (wild and hybrid variety) on hypoglycemic and hypolipidemic activity of alloxan induced type 2 diabetic long-evans rats. Journal of Diabetes Mellitus, 2, 131-137. doi: 10.4236/jdm.2012.21022.

References

[1] Ogbonnia, S.O., Odimegwu, J.I. and Enwuru, V.N. (2008) Evaluation of hypoglycemic and hypolipidemic effects of ethanolic extracts of Treculia africana Decne and Bryophyllum pinnatum Lam. and their mixture on streptozotocin (STZ)-induced diabetic rats. African Journal of Biotechnology, 7, 2535-2539.
[2] Edem, D.O. (2009) Hypoglycemic effects of ethanolic extracts of alligator pear seed (persea americana mill) in rats. European Journal of Scientific Research, 33, 669-678.
[3] Kristova, V., Liskoya, S., Sotnikova, S., Vojtko, R. and Kurtansky, A. (2008) Sulodexide improves endothelial dysfunction in streptozotocin-induced diabetes in rats. Physiological Research, 5, 491-494.
[4] World Health Organization (WHO) (1999) Definition, diagnosis and classification of diabetes mellitus and its complications, Part 1: Diagnosis and classification of diabetes mellitus. Report of a WHO consultation. Department of Non communicable Disease Surveillance, WHO, Geneva.
[5] American Diabetes Association (ADA) (2005) Diagnosis and classification of diabetes mellitus. Diabetes Care, 28, 37-42. doi:10.2337/diacare.28.suppl_1.S37
[6] Bastaki, S. (2005) Review diabetes mellitus and its treatment. International Journal of Diabetes and Metabolism, 13, 111-134.
[7] Trivedi, N.A., Majumder, B., Bhatt, J.D. and Hemavathi, K.G. (2004) Effect of Shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats. Indian Journal of Pharmacology, 36, 373-376.
[8] Saravanan, R., Rajendra Prasad, N. and Pugalandi, K.V. (2003) Effect of Piper betle leaf extract on alcoholic toxicity in the rat brain. Journal of Medicinal Food, 6, 261-265. doi:10.1089/10966200360716689
[9] Edijala, J.K., Asagba, S.O., Eriyamremu, G.E. and Atomatofa, U. (2005) Comparative effects of garden egg fruit, oat and apple on serum lipid profile in rats fed on a high cholesterol diet. Pakistan Journal of Nutrition, 4, 245-249. doi:10.3923/pjn.2005.245.249
[10] Gerstein, H., Yusuf, S., Bosch, J., Pogue, J., Sheridan, P., Dinccag, N., Hanefeld, M., Hoogwerf, B., Laakso, M., Mohan, V., Shaw, J., Zinman, B. and Holman, R., (2006) Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial. Lancet, 368, 1096-1105. doi:10.1016/S0140-6736(06)69420-8
[11] Kjeldsen, S.E., Julius, S., Mancia, G., McInnes, G.T., Hua, T., Weber, M.A., Coca, A., Ekman, S., Girerd, X., Jamerson, K., Larochelle, P., Macdonald, T.M., Schmieder, R.E., Schork, M.A., Stolt, P., Viskoper, R., Widimsky, J. and Zanchetti, A. (2006) Effects of valsartan compared to amlodipine on preventing type 2 diabetes in high-risk hypertensive patients: The VALUE trial. Journal of Hypertension, 24, 1405-1412. doi:10.1097/01.hjh.0000234122.55895.5b
[12] Dahanukar, S. A., Kulkarni, R.A. and Rege, N.N. (2000) Pharmacology of medicinal plants and natural products. Indian Journal of Pharmacology, 32, 81-118.
[13] Aslam, M. (1979) Interaction between curry ingredient and drug. Lancet, 17, 607. doi:10.1016/S0140-6736(79)91028-6
[14] Cupts, S.S. and Seth, C.B. (1982) Effect of momordica charentia Linn. (karela) on glucose tolerance in albino rats. Journal of Indian Medical Association, 39, 581-584.
[15] Wang, W., Miura, T., Shi, H., Ma, D. M., Zhao, Q. D., Zhang, W. P., Ishihara, E., Kanehara, M., Zhang, B. L., Gao, X. M., Zhang, D. Q. and Ishida, T. (2008) Effect of Tangzhiqing on glucose and lipd metabolism in genetically type 2 diabetes KK-Ay mice. Journal of Health Science, 54, 203-206. doi:10.1248/jhs.54.203
[16] Konkon, N.G., Adjoungoua, A.L., Manda, P., Simaga, D., N’Guessan, K.E. and Kone, B.D., (2010) Toxicological and phytochemical screening study of Mitragyna Inermis (willd.) O ktze (Rubiaceae), anti diabetic plant. Journal of Medicinal Plants Research, 2, 279-284.
[17] Grover, J.K. and Yadav, S.P. (2004) Pharmacological actions and potential uses of Momordica charantia: A review. Journal of Ethnopharmacology, 93, 123-132. doi:10.1016/j.jep.2004.03.035
[18] Akhtar, M.S., Athar, M.A. and Yaqub, M. (1981) Effect of Momordica charantia on blood glucose levels of normal and alloxan diabetic rabbits. Planta Medica, 42, 205-212. doi:10.1055/s-2007-971629
[19] Lenzen, S. (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia, 51, 216-226. doi:10.1007/s00125-007-0886-7
[20] Khan, Cr. and Shechter, Y. (1991) Oral hypoglycemic agents and the pharmacology of the endocrine pancreas. In: Theodore W.R., Alan, S.N., Taylor, P. and Gilman, Ag, Eds., Goodman and Gilman’s the Pharmacological Basis of Therapeutics, 8th Edition, McGraw-Hill, New York.
[21] Mahabir, D. and Gulliford, M.C., (1997) Use of medicinal plants for diabetes in Trinidad and Tobago. Rev Panam Salud Publica, 1, 174-179. doi:10.1590/S1020-49891997000300002
[22] Grover, J.K., Vats, V. and Rathi, S.S. (2000) Antihyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. Journal of Ethnopharmacology, 73, 461-470. doi:10.1016/S0378-8741(00)00319-6
[23] Shirwaikar Annie, Rajendran, K. and Rakesh, B. (2006) Effect of aqueous bark extracts of Garuga pinnata in streptozotocin-nicotinamide induced type-II diabetes mellitus. Journal of Ethnopharmacology, 107, 285-290. doi:10.1016/j.jep.2006.03.012
[24] Herfindal Eric, T. and Gourley Dick, R. (2001) Drug and disease management. In: Williams, L. and Wilkins, Text Book of Therapeutics, 7th Edition, McGraw-Hill Press, New York, 382-383.
[25] Dhanraj, S., Archana, J., Inder, S. and Goyal, P.K. (2007) Modulation of radiation-induced biochemical alteration in mice by rosemary (Rosmarinus officinalis) extract. Phytomedicine, 14, 701-705. doi:10.1016/j.phymed.2006.12.011

  
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