Biodegradable and bioactive porous polyurethanes scaffolds for bone tissue engineering

Abstract

Biodegradable porous polyurethanes scaffold have themselves opportunities in service, in-cluding controlled degradation rate, no-toxic degradation products. However, polyurethanes are lack of bioactive groups, which limits their application. This review gives the common modification methods, surface functionalization and blending modification. In finally, the review puts forward to the bulk modification as a new method to enhance the bioactivity of polyure-thanes.

Share and Cite:

Huang, M. , Wang, Y. and Luo, Y. (2009) Biodegradable and bioactive porous polyurethanes scaffolds for bone tissue engineering. Journal of Biomedical Science and Engineering, 2, 36-40. doi: 10.4236/jbise.2009.21007.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] J. R. Hench, (2003) Regeneration of trabecular bone using po-rous ceramics. Current Opinion in Solid State and Materials Science, 7, 301-307.
[2] Z. H. Zhou, J. M. Ruan, (2008) Preparation and bioactivity of sol-gel macroporous bioactive glass. Journal of University of Science and Technology, 15, 290-298.
[3] J. J. Guan, W. R. Wagner, (2005) Synthesis, characterization and cytocompatibility of polyurethane urea elastomers with designed elastase sensitivity. Biomacromolecules, 6, 2833-2842.
[4] J. J. Guan, K. L. Fujimoto, (2005) Preparation and characteriza-tion of highly porous, biodegradable polyurethane scaffolds for soft tissue applications. Biomaterials, 26, 3961-3971.
[5] Y. Wang, G. B. Ameer, (2002) A tough biodegradable elastomer. Nature Biotechnology, 20, 602-606.
[6] K. E. Healy, A. Rezania, (1999) Designing biomaterials to direct biological responses. Annals of the New York Academy of Sci-ences, 875, 24-25.
[7] S. A. Guelcher, K. Gallagher, (2005) Synthesis of biocompatible segmented polyurethanes from aliphatic diisocyanates and diurea diol chain extenders. Acta Biomaterialia, 1, 471-484.
[8] K. D. Kavlock, T. W. Pechar, (2007) Synthesis and characteriza-tion of segmented poly(esterurethane urea) elastomers for bone tissue engineering. Acta Biomaterialia, 3, 475-484.
[9] S. A. Guelcher, (2008) Synthesis, mechanical properties, bio-compatibility, and biodegradation of polyurethane networks from lysine polyisocyanates. Biomaterials, 29(12), 1762-1775.
[10] Y. F. Luo, Y. L. Wang, (2008) Evaluation of the cytocompatibil-ity of butanediamine and RGDS-grafted poly (d, l-lactic acid). European Polymer Journal, 44, 1390-1402.
[11] J. Y. Zhang, E. J. Beckman, (2002) Synthesis, biodegradability, and biocompatibility of lysine diisocyanate-glucose polymers. Tissue Engineering, 8(5), 771-785.
[12] X. Miao, Y. Hu, (2004) Porous calcium phosphate ceramics prepared by coating polyurethane foams with calcium phosphate cements. Materials Letters, 58, 397-402.
[13] K. Rezwan, Q. Z. Chen, (2006) Biodegradable and bioactive porous polymer /inorganic composite scaffolds for bone tissue engineering. Biomaterials, 27(18), 3413-3431.
[14] M. Gelinsky, P. B. Welzel, (2008) Porous three-dimensional scaffolds made of mineralised collagen: Preparation and proper-ties of a biomimetic nanocomposite material for tissue engineer-ing of bone. Chemical Engineering Journal, 137, 84-96.
[15] H. Shin, S. Jo, (2003) Biomimetic materials for tissue engineer-ing. Biomaterials, 24, 4353-4364.
[16] M. Bil, J. Ryszkowska, (2007) Bioactivity of polyurethane-based scaffolds coated with Bioglass. Biomedical Materials, 2(2), 93-101.
[17] A. Chetty, T. Steynberg, (2008) Hydroxyapatite-coated polyure-thane for auricular cartilage replacement: an in vitro study. Journal of Biomedical Materials Research A, 84 (2), 475-482.
[18] X. Huang, X. Miao, (2007) Novel Porous Hydroxyapatite Pre-pared by Combining H2O2 Foaming with PU Sponge and Modi-fied with PLGA and Bioactive Glass. Journal Biomaterials Ap-plications, 21(4), 351-374.
[19] C. Vitale-Brovarone, E. Verne, (2007) Development of glass- ceramic scaffolds for bone tissue engineering: Characterisation, proliferation of human osteoblasts and nodule formation. Acta Biomaterialia, 3, 199-208.
[20] M. J. Whitaker, R. A. Quirk, (2001) Growth factor release from tissue engineering scaffolds. Journal of Pharmacy and Pharma-cology, 53, 1427-1437.
[21] T. P. Richardson, W. L. Murphy, (2001) Polymeric delivery of proteins and plasmid DNA for tissue engineering and gene ther-apy. Gene Expression, 11, 47-58.
[22] J. E. Babensee, L. V. McIntire, (2000) Growth factor delivery for tissue engineering. Pharmaceutical Research, 17, 497-504.
[23] H. Shin, S. Jo, (2002) Modulation of marrow stromal osteoblast adhesion on biomimetic oligo[poly-thylene glycol) fumarate] hydrogels modified with Arg-Gly-Asp peptides and a poly (ethyleneglycol) spacer. Journal of Biomedical Materials Re-search, 61, 169-179.
[24] Y. Suzuki, M. Tanihara, (2000) Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic os-teoinduction in vivo. Journal of Biomedical Materials Research, 50, 405-409.
[25] F. Buket Basmanav, G. T. Kose, (2008) Sequential growth factor delivery from complexed microspheres for bone tissue engi-neering. Biomaterials, 29, 4195-4204.
[26] C. M. Hill, Y. H. An, (2007) Osteogenesis of Osteoblast Seeded Polyurethane-Hydroxyapatite Scaffolds in Nude Mice. Macro-molecular Symposium, 253, 94-97.
[27] G. Ryan, A. Pandit, (2006) Fabrication methods of porous metals for use in orthopaedic applications. Biomaterials, 27, 2651-2670.
[28] T. Sakura, C. Tanaka, M. Yang, (2004) Production and charac-terization of a silk-like hybrid protein, based on the polyalanine region of Samia cynthia ricini silk fibroin and a cell adhesive re-gion derived from fibronectin. Biomaterials, 25(4), 617-624.
[29] A. Rainer, S. Maria, (2008) Fabrication of bioactive glass-ce-ramic foams mimicking human bone portions for regenerative medicine” Acta Biomaterialia, 4, 362-369.
[30] Y. M. Xiao, D. X. Li, (2007) Preparation of nano-HA/PLA composite by modified-PLA for controlling the growth of HA crystals. Materials Letters, 61, 59-62.
[31] L. L. Hench, (1997) Sol-gel materials for bioceramic applica-tions. Current Opinion in Solid State and Materials Science, 2, 604-610.
[32] Z. K. Hong, P. B. Zhang, (2005) Nano-composite of poly (L-lactide) and surface grafted ydroxyapatite:Mechanical prop-erties and biocompatibility. Biomaterials, 26, 6296-6304.
[33] Qiu, X. Y., Hong, Z. K. (2005) Hydroxyapatite Surface Modi-fied by L-Lactic Acid and Its Subsequent Grafting Polymeriza-tion of L-Lactide. Biomacromolecules, 6, 1193-1199.
[34] P. L. Lin, H. W. Fang, (2007) Effects of hydroxyapatite dosage on mechanical and biological behaviors of polylactic acid com-posite materials. Materials Letters, 61, 3009-3013.
[35] H. J. Moon, K. N. Kim, (2006) Effect of calcium phosphate glass on bone formation in calvarial defects of Sprague-Dawley rats. Journal of Materials Science Materials in Medicine, 17 (9), 807-813.
[36] J. Russias, E. Saiz, (2006) Fabrication and mechanical properties of PLA/HA composites: A study of in vitro degradation. Materi-als Science and Engineering C, 26, 1289-1295.
[37] S. M. Zhang, J. Liu, (2005) Interfacial fabrication and property of hydroxyapatite/polylactide resorbable bone fixation compos-ites. Current Applied Physics, 5, 516-518.
[38] H. J. Salacinski, G. Hamilton, (2003) Surface functionalization and grafting of heparin and/or RGD by an aqueous-based proc ess to a poly(carbonate-urea)urethane cardiovascular graft for cellular engineering applications. Journal of Biomedical Materi-als Research Part A, 3(66A), 688-697.
[39] J. J. Guan, S. Michael, (2004) Biodegradable poly (ether ester urethane) urea elastomers based on poly (ether ester) triblock copolymers and putrescine: synthesis, characterization and cy-tocompatibility. Biomaterials, 25, 85-96.
[40] A. B. Jozwiak, C. M. Kielty, (2008) Surface functionalization of polyurethane for the immobilization of bioactive moieties on tissue scaffolds. Journal of Materials Chemistry, 18, 2240-2248.
[41] C. M. Li, C. Vepari, (2006) Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials, 27, 3115-3124.
[42] M. Nsksmura, M. Mie, (2008) Construction of multi-functional extracellular matrix proteins that promote tube formation of en-dothelial cells. Biomaterials, 29, 2977-2986.
[43] Y. M. Yue, K. Xu, (2008) Preparation and Characterization of Interpenetration Polymer Network Films Based on Poly (vinyl alcohol) and Poly (acrylic acid) for Drug Delivery. Journal of Applied Polymer Science, 6(108), 3836-3842.
[44] X. L. Xu, X. S. Chen, (2007) Electrospun poly (L-lactide)- grafted hydroxyapatite/poly (L-lactide) nanocomposite fibers. European Polymer Journal, 43, 3187-3196.
[45] G. B. Wei, Q. M. Jin, (2006) Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB. Journal Con-trolled Release, 112, 103-110.
[46] J. Y. Lee, S. H. Nam, (2002) Enhanced bone formation by con-trolled growth factor delivery from chitosan-based biomaterials. Journal Controlled Release, 78 (1-3), 187-197.
[47] J. A. Jansen, J. W. Vehof, (2005) Growth factor-loaded scaffolds for bone engineering. Journal Controlled Release, 101 (1-3), 127-136.
[48] S. A. Guelcher, A. Srinivasan, (2008) Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates. Biomaterials, 25, 1762- 1775.
[49] J. J. Guan, J. J. Stankus, (2007) Biodegradable elastomeric scaf-folds with basic fibroblast growth factor release. Journal Con-trolled Release, 120, 70-78.
[50] J. Ziegler, U. Mayr-Wohlfart, (2002) Adsorption and release properties of growth factors from biodegradable implants. Jour-nal of Biomedial Materials Research, 59, 422-428.
[51] T. W. King, C. W. Patrick, (2000) Development and in vitro characterization of vascular endothelial growth factor (VEGF)- loaded poly (DL-lactic-co-glycolic acid)/poly(ethylene glycol) microspheres using a solid encapsulation/single emulsion/ sol-vent extraction technique. Journal of Biomedial Materials Re-search, 51, 383-390.
[52] F. Bono, P. Rigon, (1997) Heparin inhibits the binding of basic fibroblast growth factor to cultured human aortic smooth-muscle cells. Biochemical Journal, 326, 661-668.
[53] X. F. Niu, Y. L. Wang, (2005) Arg-Gly-Asp (RGD) modified biomimetic polymeric materials. Journal of Materials Science and Technology, 21(4), 571-576.
[54] A. D. Cook, J. S. Hrkach, (1997) Characterization and develop-ment of RGD-peptide-modified poly (lactic acid-co-lysine) as an interactive, resorbable biomaterial. Journal of Biomedial Materi-als Research, 4, 513-523.
[55] D. A. Barrera, E. Zylstra, (1993) Synthesis and RGD Peptide Modification of a New Biodegradable Copolymer: Poly (lactic acid-celysine). Journal of the American Chemical Society, 115, 11010-11011.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.