Myocardial Infarction: An Overview of STEMI and NSTEMI Physiopathology and Treatment - World Journal of Cardiovascular Diseases

WJCD > Vol.8 No.11, November 2018

World Journal of Cardiovascular Diseases

Volume 8, Issue 11 (November 2018)

ISSN Print: 2164-5329 ISSN Online: 2164-5337

Google-based Impact Factor: 0.38 Citations

Myocardial Infarction: An Overview of STEMI and NSTEMI Physiopathology and Treatment ()

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Download as PDF (Size: 356KB) PP. 498-517

DOI: 10.4236/wjcd.2018.811049 10,971 Downloads 26,259 Views Citations

Author(s)

J. G. Kingma

Affiliation(s)

Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.

ABSTRACT

Patients with myocardial infarction resulting from acute coronary syndrome are classified by electrocardiographic presentation: 1-acute ST-segment elevation myocardial infarction (STEMI) or 2-non-ST-segment elevation myocardial infarction (NSTEMI). Prompt reperfusion of an infarct-related artery by percutaneous coronary interventions provides some relief of symptoms; long-term prognosis appears to be worse in STEMI compared to NSTEMI patients but clinical findings remain controversial. Reduced myocardial perfusion to the infarct area, caused in part by microvascular obstruction, is a privileged target for diverse pharmacologic or non-pharmacologic interventions (or combinations thereof) to improve clinical outcomes. To date, benefits of both pharmacologic and non-pharmacologic strategies to either limit microvascular obstruction and myocardial injury or improve myocardial perfusion are inconsistent. This review focuses on the physiopathological aspects of myocardial infarction in relation to development of STEMI/NSTEMI and on potential cardioprotective strategies.

KEYWORDS

Ischemia, Reperfusion, Infarction, Ischemia, No-Reflow, Microcirculation, Blood Flow, Ischemic Conditioning

Share and Cite:

Kingma, J. (2018) Myocardial Infarction: An Overview of STEMI and NSTEMI Physiopathology and Treatment. World Journal of Cardiovascular Diseases, 8, 498-517. doi: 10.4236/wjcd.2018.811049.

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