Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice ()
Affiliation(s)
1Department of Biology, Faculty of Science, Taif University, Taif, Saudi Arabia.
2College of Forensic Sciences, Naif Arab University for Security Sciences, Riyadh, Saudi Arabia.
3Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
ABSTRACT
Selenium nanoparticles (SeNPs) have been widely used as
anti-inflammatory and anti-toxic agent. The present study used Bacillus
tequilensis for biosynthesizing SeNPs from sodium selenite (Na2SeO3)
and investigated its ameliorative effects on acetaminophen (APAP)
hepatotoxicity in male mice. The results indicated that Alanine transaminase
(ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP)
significantly elevated in mice treated with APAP, while other liver markers
(total proteins and albumin) did not change. SeNPs either alone or in
combination with APAP showed ameliorative effects on liver enzymes to some
extents where their activities decreased to be insignificant with those of
normal group. A slight variation was shown in total antioxidant capacity (TAC).
Histopathologically, the hepatocytes of the mice treated with APAP showed
cloudy swelling and vacuolar degeneration, while those treated with SeNPs or
both SeNPs and APAP appeared more or less histologically normal. In conclusion,
SeNPs can be used to improve or replace today’s therapies of APAP
hepatotoxicity.
Share and Cite:
AL-Harbi, M. and Amer, S. (2017) Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice.
Natural Science,
9, 207-215. doi:
10.4236/ns.2017.97020.
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