Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Juana Koslay, San Luis Province, Argentina - Open Access Library Journal

OALibJ > Vol.2 No.3, March 2015

Open Access Library Journal

Volume 2, Issue 3 (March 2015)

ISSN Print: 2333-9705 ISSN Online: 2333-9721

Google-based Impact Factor: 0.73 Citations

Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Juana Koslay, San Luis Province, Argentina ()

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DOI: 10.4236/oalib.1101419 1,175 Downloads 2,353 Views Citations

Author(s)

Susana Siewert, Federico Márquez, Gisela Mendoza, Gustavo Fernández, Irma González, Marta S. Ojeda

Affiliation(s)

Laboratory of Diabetes, Department of Biochemistry and Biological Sciences, School of Chemistry, Biochemistry and Pharmacy, National University of San Luis, San Luis, Argentina.

ABSTRACT

Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as the strongest common genetic risk factors for Type 2 Diabetes Mellitus (T2DM) across multiple ethnicities. This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Juana Koslay, San Luis, Argentina. We genotyped 2 single nucleotide polymorphisms (SNP) rs7903146 and rs12255372 in controls and diabetic subjects. Association with T2DM was found for both SNPs rs7903146 and rs12255372 in the whole sample (under a dominant genetic model, the odds ratios (OR) were 3.43, 95% CI [1.879 - 6.255], p < 0.0001 and OR = 4.40, 95% CI [2.318 - 8.351], p < 0.0001, respectively). The risk conferred by homozygotes is much higher than the heterozygote carriers and it is marked in case of rs7903146. The haplotype that consisted of two minor alleles (TT) or the haplotypes carrying at least one of the minor alleles at SNP rs7903146 or rs12255372 (i.e. CT or TG) were more frequent in the group of T2DM. The impact of TCF7L2 variation on T2DM risk in Juana Koslay population is compatible with that demonstrated by a range of studies conducted in various ethnic groups.

KEYWORDS

Haplotypes, Alleles, Homozygotes, TCF7L2, Polymorphisms, Type 2 Diabetes Mellitus

Share and Cite:

Siewert, S. , Márquez, F. , Mendoza, G. , Fernández, G. , González, I. and Ojeda, M. (2015) Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Juana Koslay, San Luis Province, Argentina. Open Access Library Journal, 2, 1-10. doi: 10.4236/oalib.1101419.

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