Author(s)

Fatemeh Darvish^*, Shima Khazraee

Department of Chemistry, K.N.Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran.

An efficient procedure for the preparation of 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation of triethyl orthoformate, amine, and trimethylsilyl azide using inexpensive and environment-friendly FeCl₃ as catalyst under solvent-free conditions has been reported. The reaction generates the corresponding 1-substituted tetrazole in excellent yields.

Iron(III) Chloride, 1-Substituted-1H-1, 2, 3, 4-Tetrazoles, Amines, Triethyl Orthoformate, Solvent-Free, Trimethylsilyl Azide

Darvish, F. and Khazraee, S. (2015) FeCl₃ Catalyzed One Pot Synthesis of 1-Substituted 1H-1,2,3,4-Tetrazoles under Solvent-Free Conditions. International Journal of Organic Chemistry, 5, 75-80. doi: 10.4236/ijoc.2015.52009.