Author(s)

Munawar Hussain^1*, David J. Cahill², Valentine Akande³, Uma Gordon³

¹St. Michael’s Hospital, University Hospital Bristol NHS Foundation Trust, Bristol, UK.
²Academic Unit of Obstetrics and Gynaecology, School of clinical sciences, University of Bristol & St. Michael’s Hospital, Bristol, UK.
³Bristol Centre for Reproductive Medicine, North Bristol NHS Trust, Bristol, UK.

Purpose: To evaluate age related ovarian response to controlled ovarian hyperstimulation, clinical pregnancy and ongoing pregnancy rates beyond 20 weeks in women undergoing assisted reproduction treatment (ART) with antimullerian hormone (AMH) levels of <5 pmol/l. Methods: Retrospective analysis of data from 63 women with AMH of <5 pmol/L who underwent their first assisted reproduction treatment (In-vitro fertilization, IVF and intracytoplasmic sperm injection, ICSI) cycle. Results were analyzed after dividing patients in two groups, group 1 included women of ≤38 years and group 2 > 38 years of age. Non parametric variables were expressed as median (Interquartile range) and compared by Kruskal-Wallis test. Categorical variables were expressed as numbers with proportions (%) and compared by Fisher’s exact test. Results: There was no statistical difference in body max index, level of antimullerian hormone (AMH), follicle stimulating hormone (FSH), dose of gonadotrophins used and cycles cancellation rate in two groups. Although number of oocytes retrieved (median 5), clinical pregnancy (18.4%) and ongoing pregnancy rate beyond 20 weeks (18.4%) was higher in group 1, there was no statistical difference between the two groups. There was one miscarriage in group 2. Conclusion: Women with extremely low-serum AMH levels can still have clinical pregnancy and ongoing pregnancies beyond 20 weeks after ART, though chances will be lower than women with normal ovarian reserve.

Extremely Low Antimullerian Hormone, Assisted Reproduction Treatment, Clinical Pregnancy, Ongoing Pregnancy, Miscarriage Rate

Hussain, M. , Cahill, D. , Akande, V. and Gordon, U. (2014) Outcome of Assisted Reproduction Treatment in Women with Extremely Low Antimullerian Hormone (AMH) Levels. Open Journal of Obstetrics and Gynecology, 4, 961-966. doi: 10.4236/ojog.2014.415135.