Action of protoporphyrin-IX (PP-IX) in the lifespan of Drosophila melanogaster deficient in endogenous antioxidants, Sod and Cat - Open Journal of Animal Sciences

OJAS > Vol.3 No.4, November 2013

Volume 3, Issue 4 (November 2013)

ISSN Print: 2161-7597 ISSN Online: 2161-7627

Google-based Impact Factor: 1.39 Citations h5-index & Ranking

Action of protoporphyrin-IX (PP-IX) in the lifespan of Drosophila melanogaster deficient in endogenous antioxidants, Sod and Cat ()

HTML

Download as PDF (Size: 475KB) PP. 1-7

DOI: 10.4236/ojas.2013.34A2001 3,766 Downloads 6,302 Views Citations

Author(s)

Emilio Pimentel, Luz M. Vidal, Martha Patricia Cruces, Mariusz Krzysztof Janczur

Affiliation(s)

Departamento de Biología, Instituto Nacional de Investigaciones Nucleares (ININ), Ocoyoacac, México.
Facultad de Ciencias, Universidad Autónoma del Estado de México, Toluca, México.

ABSTRACT

Protoporphyirin-IX (PP-IX) is a precursor of the biosynthesis of the hemo group, most of the cytochromes and the chlorophylls. The PP-IX is used for medical purposes, and recently a report indicated that it exhibits a dual action since it can decrease or increase the genetic damage caused by N-nitroso-N-ethylurea (ENU) in somatic cells of Drosophila. PP-IX is known to be able to act as an anti-or pro-oxidant agent. The aim of the present research was to study the role of PP-IX on the lifespan of Drosophila melanogaster, taking into account the fact that increasing levels of ROS can accelerate the aging process. The Canton-S strain (CS) was used as well as Sod and Cat which are deficient in the endogenous enzymes, superoxide dismutase and catalase, respectively. Groups of females and males were treated separately with 5 mg/ml of PP-IX solution. The comparison of survival curves indicates that this pigment extended the lifespan of CS. In contrast, Sod strain showed that the opposite effect and had no effect in Cat strain. The fact that PP-IX reduces the mean lifespan in Sod deficient strain might suggest a pro-oxidant action of PP-IX, and consequently the cumulating of ROS as a superoxide could have a mutagenic effect as was shown recently. The results presented evidence of the dual effect of PP-IX.

KEYWORDS

Protoporphyrin IX (PP-IX); Lifespan; Sod; Cat; Reactive Oxygen Species; Longevity; Drosophila melanogaster

Share and Cite:

Pimentel, E. , Vidal, L. , Cruces, M. and Janczur, M. (2013) Action of protoporphyrin-IX (PP-IX) in the lifespan of Drosophila melanogaster deficient in endogenous antioxidants, Sod and Cat. Open Journal of Animal Sciences, 3, 1-7. doi: 10.4236/ojas.2013.34A2001.

Cited by

[1]	Relationship between lifespan and somatic mutation in D. melanogaster after treatment with chlorophyllin
	Environmental …, 2022

[2]	Sexual deprivation induces a CRF independent stress response and decreases resistance to stressors in Drosophila via a subpopulation of Neuropeptide F receptor …
	bioRxiv, 2022

[3]	Radioprotective effect of chloropyllin, protoporphyrin-IX and bilirubin compared with amifostine® in Drosophila melanogaster
	2020

[4]	Covariation between eggshell colouration and eggshell bacteria abundance and egg characteristics in blackbirds
	2019

[5]	Eggshell Biliverdin and Protoporphyrin Pigments in a Songbird: Are They Derived from Erythrocytes, Blood Plasma, or the Shell Gland?
	2017

[6]	Habitat geology influences intraspecific variation in the speckling patterns of Blue Tit Cyanistes caeruleus and Great Tit Parus major eggs
	Acta Ornithologica, 2017

[7]	Biliverdin-and protoporphyrin-based eggshell pigmentation in relation to antioxidant supplementation, female characteristics and egg traits in the canary (Serinus …
	Behavioral Ecology and Sociobiology, 2016

[8]	Effects of breeding habitat (woodland versus urban) and metal pollution on the egg characteristics of great tits (Parus major)
	Science of The Total Environment, 2016

[9]	Darker eggshell spotting indicates lower yolk antioxidant level and poorer female quality in the Eurasian Great Tit (Parus major)
	The Auk, 2016

[10]	Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands
	International Journal of Molecular Sciences, 2016

[11]	抗氧化剂与延长寿命的相关性研究进展
	中国药理学与毒理学杂志, 2016

[12]	Effects of environmental conditions on the egg mass, yolk antioxidant level, eggshell thickness and eggshell spotting patterns of Great Tits (Parus major)
	Journal of Ornithology, 2016

[13]	Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy
	Mutation Research/Reviews in Mutation Research, 2016

[14]	Biliverdin-and protoporphyrin-based eggshell pigmentation in relation to antioxidant supplementation, female characteristics and egg traits in the canary (Serinus …
	Behavioral Ecology and Sociobiology, 2016

[15]	MODULACIÓN DEL DAÑO GENÉTICO POR LA PROTOPORFIRINA
	2014

[16]	MODULACIÓN DEL DAÑO GENÉTICO POR LA PROTOPORFIRINAIX EN D. melanogaster DEFICIENTE EN Cat y Sod Y TRATADA CON CASIOPEINA (Cas III-Ea) Y Cr (VI)
	2014

[17]	MODULACIÓN DEL DAÑO GENÉTICO POR LA PROTOPORFIRINAIX EN D. melanogaster DEFICIENTE EN Cat y Sod Y TRATADA CON CASIOPEINA ( …
	2014

[18]	Genetic damage induced by CrO 3 can be reduced by low doses of Protoporphyrin-IX in somatic cells of Drosophila melanogaster
	Toxicology Reports, 2014

[19]	MODULACIóN DEL DA?O GENéTICO POR LA PROTOPORFIRINAIX EN D. melanogaster DEFICIENTE EN Cat y Sod Y TRATADA CON CASIOPEINA (Cas III-Ea) Y Cr (VI)”
	2014

[20]	Genetic damage induced by CrO3 can be reduced by low doses of Protoporphyrin-IX in somatic cells of Drosophila melanogaster
	Toxicology Reports, 2014

[21]	MODULACIÓN DEL DAÑO GENÉTICO POR LA PROTOPORFIRINAIX EN D. melanogaster DEFICIENTE EN Cat y Sod Y TRATADA CON CASIOPEINA (Cas III …
	2014

[22]	Evaluation of the oxidative stress modulation in Drosophila melanogaster strains deficient in endogenous antioxidants and with chronic exposure to casiopeina Cas II …
	2013

[23]	RELACIÓN ENTRE EL DAÑO GENÉTICO Y LONGEVIDAD PROVOCADA POR DOS RAZONES DE DOSIS DE RAYOS GAMA Y SU MODULACIÓN CON …


[24]	Modulación del daño genético inducido por diferentes razones de dosis de radiación ionizante mediante protoporfirina, clorofilina o bilirrubina en Drosophila …

Journals Menu

Follow SCIRP

	+1 323-425-8868
	customer@scirp.org
	+86 18163351462(WhatsApp)
	1655362766

	Paper Publishing WeChat

Journals Menu

Home

About SCIRP

Service

Policies