World Journal of Neuroscience

Volume 3, Issue 4 (November 2013)

ISSN Print: 2162-2000   ISSN Online: 2162-2019

Google-based Impact Factor: 0.68  Citations  h5-index & Ranking

Recovery of nigrostriatal dopaminergic system insufficiency by allotransplantation of embryonic brain tissue

Full-Text HTML  XML Download Download as PDF (Size: 307KB)  PP. 240-245  

ABSTRACT

In an experiment in rats with electrolytic lesion of the compact part of substantia nigra (SN) and after allotransplantation of the embryonic tissue of SN in the caudate nucleus the features of movement and emotional behavior in the Open Field Test (OFT), the rotation movements caused by an administration of amphetamine, a content of catecholamines in the caudate nucleus, hypothalamus and blood plasma have been investigated. It is shown that the electrolytic lesion causes violations of the statokinetic reflexes, the horizontal and the vertical movement activity, enhances the rotatory behavior, slow the orienttate-searching and the emotional reactions that combined with disbalance in dopamine-and noradrenalinetransmitter systems functioning. Allotransplantation of the embryonic dofaminsynthesizing brain tissue contributes to the restoration of movement activeity and its specific neurotransmitter ensuring. 

Cite this paper

Berchenko, O. and Usmentseva, Y. (2013) Recovery of nigrostriatal dopaminergic system insufficiency by allotransplantation of embryonic brain tissue. World Journal of Neuroscience, 3, 240-245. doi: 10.4236/wjns.2013.34032.

Cited by

No relevant information.

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.