World Journal of Neuroscience

Volume 3, Issue 2 (May 2013)

ISSN Print: 2162-2000   ISSN Online: 2162-2019

Google-based Impact Factor: 0.68  Citations  h5-index & Ranking

Acute statin treatment improves recovery after experimental intracerebral hemorrhage

Full-Text HTML  XML Download Download as PDF (Size: 671KB)  PP. 69-75  

ABSTRACT

Background and Purpose: We have previously demonstrated that 2-week treatment of experimental intracerebral hemorrhage (ICH) with a daily dose of 2 mg/kg statin starting 24 hours post-injury exerts a neuroprotective effect. The present study extends our previous investigation and tests the effect of acute high-dose (within 24 hours) statin therapy on experimental ICH. Material and Methods: Fifty-six male wistar rats were subjected to ICHby stereotactic injection of 100 μl of autologous blood into the striatum. Rats were divided randomly into seven groups: saline control group (n = 8); 10, 20 and 40 mg/kg simvastatin-treated groups (n = 8); and 10, 20 and 40 mg/kg atorvastatin-treated groups (n = 8). Simvastatin or atorvastatin were administered orally at 3 and 24 hours after ICH. Neurological functional outcome was evaluated using behavioral tests (mNSS and corner turn test) at multiple time points afterICH. Animals were sacrificed at 28 days after treatment, and histological studies were completed. Results: Acute treatment with simvastatin or atorvastatin at doses of 10 and 20 mg/kg, but not at 40 mg/kg, significantly enhanced recovery of neurological function starting from 2 weeks post-ICH and persisting for up to 4 weeks postICH. In addition, at doses of 10 mg/kg and 20 mg/kg, histological evaluations revealed that simvastatin or atorvastatin reduced tissue loss, increased cell proliferation in the subventricular zone and enhanced vascular density and synaptogenesis in the hematoma boundary zone when compared to salinetreated rats. Conclusions: Treatment with simvastatin or atorvastatin at doses of 10 and 20 mg/kg significantly improves neurological recovery after administration during the first 24 hours after ICH. Decreased tissue loss, increased cell proliferation and vascularity likely contribute to improved functional recovery in rats treated with statins after ICH.

Cite this paper

Yang, D. , Zhang, J. , Han, Y. , James, E. , Chopp, M. and Seyfried, D. (2013) Acute statin treatment improves recovery after experimental intracerebral hemorrhage. World Journal of Neuroscience, 3, 69-75. doi: 10.4236/wjns.2013.32010.

Cited by

[1] Protective effects of atorvastatin against morphine-induced tolerance and dependence in mice
Brain Research, 2017
[2] Use of statins and outcomes in intracerebral hemorrhage patients
2017
[3] Simvastatin prevents morphine-induced tolerance and dependence in mice
Biomedicine & Pharmacotherapy, 2017
[4] The pre-ICH and in-hospital statins use in intracerebral hemorrhage: a systematic review and meta-analysis
World Neurosurgery, 2017
[5] Untersuchung der Anwendung von Statinen bei primär spontanen intracerebralen Blutungen
2017
[6] Untersuchung der Anwendung von Statinen bei primär spontanenintracerebralen Blutungen
Dissertation, 2016
[7] Intracerebral Hemorrhage: Perihemorrhagic Edema and Secondary Hematoma Expansion: From Bench Work to Ongoing Controversies
Frontiers in neurology, 2016
[8] Statin use after intracerebral hemorrhage: a 10‐year nationwide cohort study
Brain and behavior, 2016
[9] Blood lipid levels, statin therapy and the risk of intracerebral hemorrhage
Lipids in health and disease, 2016
[10] Statins in Intracerebral Hemorrhage
Current atherosclerosis reports, 2015
[11] Statins in nervous system-associated diseases: angels or devils?
Die Pharmazie-An International Journal of Pharmaceutical Sciences , 2014
[12] Effects and clinical application of statins
Chinese Medical Journal, 2013
[13] Statins and intracerebral hemorrhage.
Chinese medical journal, 2013

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.