Journal of Cancer Therapy

Volume 2, Issue 5 (December 2011)

ISSN Print: 2151-1934   ISSN Online: 2151-1942

Google-based Impact Factor: 0.30  Citations  h5-index & Ranking

Different Effects of TERT, TP63, and CYP2A6 Polymorphism on Individual Risk of Tobacco-Related Lung Cancer in Male Japanese Smokers

HTML  Download Download as PDF (Size: 187KB)  PP. 690-696  
DOI: 10.4236/jct.2011.25093    4,266 Downloads   7,706 Views  Citations

Affiliation(s)

.

ABSTRACT

Recent genome-wide association studies have identified lung cancer susceptibility loci, such as chromosome 5p15 (telomerase reverse transcriptase, TERT and cleft lip and palate transmembrane protein 1-like, CLPTM1L), 15q25 (nicotinic cholinergic receptor α, CHRNA3-CHRNA5), and 3q28 (tumor protein p63, TP63). Replication study was performed to confirm the association of the recently-identified susceptible loci (i.e., TERT-CLPTM1L, CHRNA3-CHRNA5, and TP63) in a total of 1460 male Japanese smokers (885 lung cancer cases and 575 healthy control subjects), which were previously studied for a low odds ratio of impaired or deletion polymorphism in cytochrome P450 2A6 (CYP2A6) for lung cancer risk. The minor allele frequency (0.442) of rs2736100 on 5p15 (TERT) was significantly higher in lung cancer cases than that (0.395) of controls, with an odds ratio of 1.27 (95% CI of 1.07 - 1.50, p = 0.00504). A series of subgroup analyses revealed the significant associations of rs4488809 (TP63, odds ratio of 1.21, p = 0.0422) and rs2736100 (TERT, odds ratio of 1.47, p = 6.40 × 10–5) with the risk of lung adenocarcinoma. No significant association of CHRNA3-CHRNA5 and CLPTM1L was found in this population. The present results support replication of the association of TERT and TP63 loci with lung adenocarcinomas and suggest subtype-specific effects of these loci on higher risk of lung cancer in smokers. The CYP2A6 including copy number polymorphism, uninvestigated in large-scale genome-wide association studies, may influence lower risk to heavy tobacco use-related lung cancer.

Share and Cite:

M. Shimizu, K. Kiyotani, H. Kunitoh, T. Kamataki and H. Yamazaki, "Different Effects of TERT, TP63, and CYP2A6 Polymorphism on Individual Risk of Tobacco-Related Lung Cancer in Male Japanese Smokers," Journal of Cancer Therapy, Vol. 2 No. 5, 2011, pp. 690-696. doi: 10.4236/jct.2011.25093.

Cited by

[1] Polymorphism in the TP63 gene imparts a potential risk for leukemia in the North Indian population
African Health …, 2021
[2] Differences in Toxicological and Pharmacological Responses Mediated by Polymorphic Cytochromes P450 and Related Drug-Metabolizing Enzymes
Chemical Research in Toxicology, 2016
[3] Data in Brief
2015
[4] Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with …
Clinica Chimica Acta, 2015
[5] Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time polymerase chain reaction method with dual-labeled probes
Clinica Chimica Acta, 2015
[6] Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6* 4) by real-time polymerase chain reaction platforms
Data in Brief, 2015
[7] Species, Ethnic, and Individual Differences in Human Drug-Metabolizing Cytochrome P450 P450 Enzymes
Fifty Years of Cytochrome P450 Research, 2014
[8] Species, ethnic, and individual differences in human drug-metabolizing cytochrome P450 enzymes
2014
[9] Effects of ADH1C, ALDH2, and CYP2A6 Polymorphisms on Individual Risk of Tobacco-Related Lung Cancer in Male Japanese Smokers
Journal of Cancer Therapy, 2013
[10] TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications
PloS one, 2012
[11] Cytochrome P450 2A6 phenotyping based on dietary caffeine intake in a Japanese population of non-smokers
Drug metabolism letters, 2012

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.