Non-Drug Therapy to Combat Coronavirus

Novel coronavirus is threatening the health of people all over the world and all possible treatment strategies are in urgent. The sensitive of virus to heat proposed temperature treatment as an effective method against coronavirus. Here, we proposed several non-drug therapies including far-infrared, thermal air, thermal oxygen, ozone, hydrogen therapy and plasma physical therapy for immediate clinical trial and implementation. Compared with the drug therapy, these methods are safe without side effects, the highest benefit-to-risk ra-tio, user-friendly, and low implementation costs. It is urgent and significant to start these non-drug therapeutic design and implementation as early as possible, to determine the safety and effectiveness of these therapeutic methods.

Open Journal of Regenerative Medicine the temperature of the human body is 37.5˚C, the visceral vitality was enhanced by 5 -6 times [3]. With the body temperature of 37˚C, the blood circulation is good, while the basic metabolism is reduced by 12% at 36.5˚C and the immune function is reduced by 37% at 36˚C. So, we have to find a way to improve the body's immunity by increasing the body's temperature. Here, we exemplify these thermal related treatment methods including: far infrared heating, inhalation of thermal air, alternative oxygen and hydrogen therapy, mixture of ozone and air, physical plasma treatment, etc.

Treatment Plan with New Ventilator
The novel ventilator of this solution is to kill the virus by increasing the temperature of the inhaled gas and mixing some micro-ozone. In general, the temperature of people's inhaled air depends on the ambient temperature, usually 20˚C.
The temperature of exhaled gas is about 36˚C, almost the same as that of health human body. Normally, the resting adult respiratory cycle time is about 6.4 seconds, and the average breath volume is about 500 ml per breath. Calculated according to thermal formula (Q = cm(T 2 − T 1 ), where c is the air specific heat capacity, m is the air mass, T is the air temperature), supposing the temperature difference between the inhaled and exhaled air is calculated as 16˚C, the breathing energy loss of the human body is about 1386 calorie/h. If we can breathe 36 ~ 37 degrees of air, almost the same as body's temperature, which means that we will greatly reduce the burden of heat exchange of respiratory organs and save energy consumption of the body. The new ventilator's design concept is to add a gas relatively thermostatic heater (36˚C ~ 37˚C), a pulse gas heater and a pulse micro-ozoner in the breathing tube of the ordinary ventilator, as shown in Figure 1. This new type of ventilator [4] will supply the thermostatic (36˚C -37˚C) oxygen and air, the pulse heated oxygen and air, as  well as the pulse micro-ozone. The breathing energy heating loss can be saved with using the thermostatic heater. By using the pulse heater, the temperature of the pulse inhaled gases can be instantly raised to 60˚C -80˚C, such pulse thermal gases entering the lung can kill the virus quickly. Furthermore, the pulsed micro-ozone added by the bypass should have a better therapeutic effect of killing coronavirus in the lungs. Why do we use pulse mode, because it is safer and more comfortable for human body.

New Treatment Cabin Plan
The non-drug comprehensive treatment methods are composed of far-infrared heating therapy, oxygen therapy [5], hydrogen therapy [6], and ozone therapy.
These treatment units form a complex treatment cabin [7] system, as shown in Figure 2. The treatment cabin has a chamber that contains a temperature-controllable far-infrared heater, an air inlets, an exhausts port, a bluetooth microphone, and the human body monitoring sensors, etc. This chamber is set at a sauna-like temperature of 50˚C ~ 70˚C. Such temperature is the typical temperature of sauna-room, so this kind of temperature gas is safe for human body, but, it is deadly for the virus.
With this treatment chamber, the patient can be in a sitting position or on-the-fly therapy. Different comprehensive treatment methods can be adopted according to the patient's symptoms. For example, when the far-infrared thermotherapy is being used, oxygen, air and micro ozone can also be introduced into the thermal cabin chamber. In addition, hydrogen therapy can be used alternately to achieve better therapeutic effect on killing virus probably.
Why does this cabin chamber have therapeutic effect? This is based on the previous trial judgment. Experiments have proved that the far infrared heater can effectively enhance the body's temperature, cure the flu and expel the virus by sweating [8]. The thermal effect of far infrared can promote the speed of blood flow, which means that the white cells in the blood will move more quickly to detect and kill the virus. In addition, elevated body temperature will accelerate the

Cold Plasma Physical Treatment Plan
Low temperature cold plasmas have been widely used to sterilize and kill viruses and germs [12] [13] [14], treating diseases caused by various infections [15] [16] [17], because it contains a huge number of energetic particles including electrons, ions, free radicals, ozone, etc.. Based on the previous researches and a single dielectric barrier electrode plasma generator [18], we have designed a nostril plasma sterilizer [19] which can be easily inserted into the nostril, as shown in Figure 3. A micro-discharge plasma can be produced in the casing gap on the side of the ground electrode wall of the shell, as shown in Figure 3 (right). Such a plasma is an air micro-discharge that can produce micro-ozone in the nostril, and its intensity can be modified by controlling a small power supply driven by rechargeable battery. It can be easily attached to clothes. Especially, this plasma sterilizer is safe for the human body with a very small power supply of less than 1 watt.
By easily wearing such a nostril sterilizer, the patient with mild symptoms may inhale some micro-ozone regularly and quantitatively each day to kill the viruses in the nasal cavity, respiratory tract, and lungs. For normal person, you also can reuse and ware it to replace the mask in high-risk infection room with dense crowds.

Conclusions
Three kinds of non-drug treatment plans are proposed in this paper, including: 1) A new ventilator, which adopts the following improvements: a. Heating the temperature of the inhaled gas to the body's temperature to reduce the burden of pulmonary thermal exchange and save the body energy consumption; b. Using a pulse inhaled gas to kill the virus, c. Using the inhaled micro-ozone to kill the virus. 2) A treatment chamber, which combines the far-infrared thermotherapy, thermal oxygen therapy, thermal air therapy and thermal micro-ozone to improve 3) The pulse plasma physical micro-discharge tubes, which can be worn easily, to kill the virus in the nasal cavity and then use the inhaled ozone produced by the plasma to kill the virus.
Although the above treatment methods and instruments are still in the early stage, they provide new plans and means for defeating the world epidemic. We are trying to speed up the improvement of these treatment products and start the clinical verification as soon as possible, so as to help the people suffering from the virus to get rid of the pain as soon as possible.
In this emergency period, especially considering the shortage of medical equipment and supplies all over the world, as a temporary emergency method, the authors recommend that the mild patient uses a sauna room with the temperature from 50˚C to 70˚C to fight against the virus.