Unilateral Frontal Sinus Aspergillosis: A Case Report and Review Literature

Frontal sinus aspergillosis is a rare infection that can be usually associated with immunocompromised states and life-threatening with high mortality rate. The authors report in a developing country a case of immunocompetent patient with left unilateral frontal headache, associated with left eye ptosis. The Brain CT Scan revealed frontal sinus aspergillosis. She underwent surgery followed by itraconazole cure. The outcome is successful after a period of 14 months with resolution of symptomatology. Anatomopathological exami-nation confirmed aspergillosis. They share their experience of management of this disease in a country where neurosurgery is very young specialty and where molecules against aspergillosis are not available. and it’s an underdiagnosed disease in immunocompetent patients. We report a case of an immunocompetent woman, agricultural worker in Central Africa country: Chad, with a unilateral frontal sinus aspergilloma and a review of literature.


Introduction
Aspergillus is the most common fungal infection of the paranasal sinuses and usually appears as a chronic disease in an otherwise healthy patient. Frontal sinus aspergillosis is a rare infection that can be usually associated with immunocompromised states and life-threatening with high mortality rate [1]. The literature described a higher incidence of Aspergillus granuloma in Sudan, India, Pakistan and Saudi Arabia [2]. The frontal sinus is usually secondary to the participation of one of the other sinuses and it's an underdiagnosed disease in immunocompetent patients. We report a case of an immunocompetent woman, agricultural worker in Central Africa country: Chad, with a unilateral frontal sinus aspergilloma and a review of literature.

Case Report
We report a case of a 52-year-old female patient seen in consultation for left unilateral frontal headache, associated with ptosis of the left eye for which she was previously followed in ophthalmology. The past medical history began 08 months ago with a unilateral headache partially calmed by over the counter analgesics. An ipsilateral ptosis gradually settled with exophthalmos. She had diplopia of the left eye. The patient did not have another known medical condition and was not on any immunosuppressive therapy. The cerebral CT scan revealed a hyperdense left intraorbital tissue formation with lysis of the roof of the orbit and the anterior wall of the blown fore sinus (Figure 1). The ipsilateral frontal sinus was filled and contained calcifications. The radiological diagnosis of aspergillosis was retained. There was no leukopenia biologically.
Surgical intervention was performed with a left unilateral frontal approach.
There is a problem of greenish material from the frontal sinus with hard lumps ( Figure 2). The frontal sinus was cranialized and separated from the anterior stage by the galea passed below the frontal lobe lining the anterior stage. The culture of the sample in search of aerobic or anaerobic germs was negative. After surgical intervention the ptosis disappeared. The pathology study concluded with aspergillus niger (Figure 3), and a treatment based on itraconazole was initiated.
She was followed for a period of 14 months without anything in particular.

Discussion
Aspergillosis of the paranasal sinuses can arise from a hematogenous dissemination or a pulmonary infection or by direct contamination of the paranasal sinus.
We did not find the starting point of the infection in our patient, but we think that it would probably have spread from latent pulmonary tuberculosis since the   patient is from an area where pulmonary tuberculosis can remain latent, which is associated with a tropical climate.
Aspergillosis disease has often been reported in areas that have a hot dry climate like in Sudan and the Middle East, and also in areas with temperate climates like India and Pakistan [2]. The patient lives in an area where precipitation reaches 1100 mm of rain per year with a temperate climate. This climate is similar to that of the South Sudan border. Humidity and a temperate climate, favor the growth of the fungus [2]. Dong Hoon reports in his study that aspergillus granulomas is more particularly to develop in immunocompromised individuals [3].

Leboime et al. reported that the risk of infection is increased in patients with
immobility, skin breaks, joint surgery, rheumatoid arthritis, leukopenia, diabetes mellitus, and chronic lung diseases [4]. There is no evidence of pulmonary tuberculosis with the patient. Sinus aspergilloma may remain asymptomatic but the clinical manifestation of this rare disease is related to complications, by the orbital or intracranial invasion. Nasal symptoms are absent [6]. Our patient presented with an orbital extension of exophtalmos, ophthalmoplegia, visual compromise, and headaches evolving for 9 months. These symptoms have also been reported by Swoboda et al. [6], they reported the case of a patient with frontal sinus aspergilloma with a right sided pyocele expanding into the orbit. For intracranial aspergillosis, the patient presents with signs and symptoms of space occupying lesions [7], but all cases had a long history of headaches and nasal obstruction.
The culture of the sample taken in our patient was negative for the aerobic and anaerobic germs. This has also been reported by Pradeep et al. [7].
The entry of fungi into the host system is typically via the respiratory tract [3], via wounds for aspergillus conidia, via ingestion and/or via the hematogenous dissemination to the brain or sinuses. However, in our case study, we think that the entry was via the respiratory tract.
The frontal sinus is a rare location, according to Zachary et al. [8], fungal balls are common in middle aged or elderly women, often with a normal functioning immune system, and that workers in the agricultural fields or in the construction fields are more commonly exposed to inhale fungal spores [2]; which is the case of our patient; an agricultural worker.
The patient underwent a brain CT scan for an investigation. Some authors claim that CT scan is best for diagnosing sinus aspergilloma showing sinuses involved by the presence of a hyperdense mass with bony expansions or erosion of the cranial base [4]. Although a CT scan and an MRI can reveal the diagnosis.
The definitive diagnostic investigation is the histopathologic confirmation.
According to the Siddiqui et al. [9] classification, our patient is a type 3 (Table   1).  [4], some doctors recommend liposomal Amphotericin B until the presence of Aspergillus is confirmed, and then Voriconazole is recommended [11]. However, we use Voriconazole without Amphotericin B after the diagnosis is confirmed. The surgical's goal is total removal of the fungi from the sinuse to avoid any reoccurrences.
For Gungor et al., despite surgery followed by oral Voriconazole, mortality rates varied from 28% -85% [12], this fact can maybe be explained because of Voriconazole resistance. Otto and Delgaudio recommend following patients at least until there is a regeneration of the sinus mucosa. However in our case, our patient was followed for 14 months.

Conclusion
Frontal Aspergillus sinusitis is an opportunistic infection with a low incidence that can occur in immunocompromised patients. Early surgery and antifungal treatment can improve prognosis.